SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m8h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		5 / 10 THR A  78
TYR A  98
GLN A 118
GLU A 122
GLY A 285
 SR  A 401 (-3.4A)
None
MPD  A 407 (-4.2A)
None
MPD  A 406 ( 3.9A)
 1.14A 1httA-5m8hA:
24.9		 1httA-5m8hA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		4 / 8 PHE A 162
TYR A 183
LEU A 179
ASP A 175
 None
 1.11A 1rmtD-5m8hA:
undetectable		 1rmtD-5m8hA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 12 LEU E 110
ALA E  44
VAL E  67
LEU E  28
ILE E 112
 None
 1.11A 1s9pA-5m8hE:
undetectable		 1s9pA-5m8hE:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 11 ILE E 195
LEU E 117
ASP E  94
GLY E  92
VAL E 177
 None
 1.04A 2fxdA-5m8hE:
undetectable		 2fxdA-5m8hE:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		4 / 8 ILE A 136
LEU A 152
THR A 305
VAL A 283
 MPD  A 406 (-4.6A)
None
MPD  A 406 (-3.8A)
None
 0.80A 3dcjB-5m8hA:
undetectable		 3dcjB-5m8hA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		5 / 12 PHE A 204
LEU A 165
ARG A 164
ILE A 235
LEU A 207
 None
 1.07A 3nrrA-5m8hA:
undetectable		 3nrrA-5m8hA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		4 / 7 ARG A  95
VAL A 283
GLY A 285
VAL A 138
 None
None
MPD  A 406 ( 3.9A)
None
 0.75A 3ufnB-5m8hA:
undetectable		 3ufnB-5m8hA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 12 TYR E 145
ASP E 193
GLN E 152
VAL E 153
ILE E 134
 None
 1.25A 4drhA-5m8hE:
undetectable		 4drhA-5m8hE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 11 TYR E 145
ASP E 193
GLN E 152
VAL E 153
ILE E 134
 None
 1.22A 4driA-5m8hE:
undetectable		 4driA-5m8hE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		4 / 7 GLY E 121
ILE E 134
LEU E 132
PHE E 146
 None
 0.77A 4ejjD-5m8hE:
undetectable		 4ejjD-5m8hE:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		5 / 11 ILE A 161
PHE A 162
ALA A 208
LEU A 207
LEU A 165
 None
 0.92A 4g1bB-5m8hA:
undetectable		 4g1bB-5m8hA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 10 LEU E  26
ILE E 219
LEU E 216
LEU E  41
PHE E  88
 None
 0.81A 4odoA-5m8hE:
undetectable		 4odoA-5m8hE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 10 LEU E  26
LEU E 215
LEU E 216
LEU E  41
PHE E  88
 None
 0.92A 4odoA-5m8hE:
undetectable		 4odoA-5m8hE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 10 LEU E  26
LEU E 215
LEU E 216
LEU E  41
PHE E  88
 None
 0.96A 4odoB-5m8hE:
undetectable		 4odoB-5m8hE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 10 LEU E  26
ILE E 219
LEU E 216
LEU E  41
PHE E  88
 None
 0.87A 4odoC-5m8hE:
undetectable		 4odoC-5m8hE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 10 LEU E  26
LEU E 215
LEU E 216
LEU E  41
PHE E  88
 None
 0.98A 4odoC-5m8hE:
undetectable		 4odoC-5m8hE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		5 / 12 LEU A  55
GLU A  42
PRO A  79
THR A  78
GLU A 122
 None
None
None
SR  A 401 (-3.4A)
None
 1.36A 4q15B-5m8hA:
16.6		 4q15B-5m8hA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		3 / 3 MET A 367
ASP A 329
PHE A 333
 None
 1.02A 4xeyA-5m8hA:
1.0		 4xeyA-5m8hA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		3 / 3 MET A 367
ASP A 329
PHE A 333
 None
 1.05A 4xeyB-5m8hA:
1.2		 4xeyB-5m8hA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		5 / 12 ILE A 143
VAL A 311
LEU A 152
THR A 318
MET A 309
 None
 1.17A 5bykA-5m8hA:
undetectable		 5bykA-5m8hA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		5 / 12 THR A  78
GLN A 118
GLU A 122
GLY A 285
GLY A 306
 SR  A 401 (-3.4A)
MPD  A 407 (-4.2A)
None
MPD  A 406 ( 3.9A)
MPD  A 406 (-3.9A)
 1.00A 5e3iA-5m8hA:
24.9		 5e3iA-5m8hA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		5 / 11 THR A  78
GLN A 118
GLU A 122
GLY A 285
GLY A 306
 SR  A 401 (-3.4A)
MPD  A 407 (-4.2A)
None
MPD  A 406 ( 3.9A)
MPD  A 406 (-3.9A)
 0.97A 5e3iB-5m8hA:
25.2		 5e3iB-5m8hA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		3 / 3 ALA A 332
ASN A 335
LEU A 336
 None
 0.18A 5i1nB-5m8hA:
undetectable		 5i1nB-5m8hA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		3 / 3 ALA A 332
ASN A 335
LEU A 336
 None
 0.23A 5i1oC-5m8hA:
undetectable		 5i1oC-5m8hA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		3 / 3 ALA A 332
ASN A 335
LEU A 336
 None
 0.19A 5i1pA-5m8hA:
undetectable		 5i1pA-5m8hA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 12 PHE E 223
VAL E  90
ILE E 219
LEU E  41
PHE E  88
 None
 1.24A 5im2A-5m8hE:
6.4		 5im2A-5m8hE:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 12 PHE E 223
ILE E 219
LEU E 216
ALA E  27
LEU E  41
 None
 0.91A 5km9B-5m8hE:
undetectable		 5km9B-5m8hE:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		3 / 3 THR A 160
THR A 305
LEU A 241
 None
MPD  A 406 (-3.8A)
None
 0.62A 5m66D-5m8hA:
undetectable		 5m66D-5m8hA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 10 ALA E  27
VAL E  69
ILE E 219
PHE E  88
ALA E  86
 None
 1.13A 5nukA-5m8hE:
undetectable		 5nukA-5m8hE:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		4 / 6 HIS A 264
LEU A  55
PRO A  79
SER A  49
 None
 1.15A 5syjA-5m8hA:
undetectable		 5syjA-5m8hA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		4 / 6 HIS A 264
LEU A  55
PRO A  79
SER A  49
 None
 1.13A 5syjB-5m8hA:
undetectable		 5syjB-5m8hA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		4 / 9 LYS A 230
ILE A 231
ILE A 235
LEU A 238
 None
 0.53A 5vkqB-5m8hA:
undetectable
5vkqC-5m8hA:
undetectable		 5vkqB-5m8hA:
13.26
5vkqC-5m8hA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		5 / 12 LEU A  55
GLU A  42
PRO A  79
THR A  78
GLU A 122
 None
None
None
SR  A 401 (-3.4A)
None
 1.25A 5xipD-5m8hA:
15.6		 5xipD-5m8hA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Psychrobacter
arcticus) 		5 / 12 PHE E  88
VAL E  90
GLY E  89
LEU E 110
SER E 226
 None
 1.48A 6ci6A-5m8hE:
undetectable		 6ci6A-5m8hE:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		5 / 9 LEU A 375
SER A 376
ARG A 374
PRO A 361
ILE A 328
 None
 1.20A 6ef6A-5m8hA:
1.1		 6ef6A-5m8hA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Psychrobacter
arcticus) 		4 / 7 HIS A 158
THR A 160
ARG A 240
ASP A 236
 None
 1.05A 6mn4E-5m8hA:
undetectable		 6mn4E-5m8hA:
23.21