SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 12 MET A 491
LEU A 412
PHE A 409
LEU A 117
ILE A 464
 None
 1.36A 1hrkB-5m8jA:
undetectable		 1hrkB-5m8jA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 6 ASP A  18
GLY A 166
ILE A 165
ILE A 349
 None
 0.94A 1n49D-5m8jA:
undetectable		 1n49D-5m8jA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		3 / 3 ALA A 281
VAL A 279
TRP A  55
 None
 0.97A 1tkqA-5m8jA:
undetectable		 1tkqA-5m8jA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 12 HIS A 396
GLY A 132
LEU A 140
LEU A 336
SER A 388
 None
 1.26A 1zq9A-5m8jA:
undetectable		 1zq9A-5m8jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 12 PHE A 358
ILE A 354
VAL A 449
LEU A 422
ILE A 418
 None
 1.33A 3em0B-5m8jA:
undetectable		 3em0B-5m8jA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 12 TRP A  55
GLY A 132
ALA A 133
LEU A 137
LEU A 140
 None
 0.80A 3hs6A-5m8jA:
undetectable		 3hs6A-5m8jA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 9 ILE A 502
PHE A 239
PHE A 114
GLY A 111
PHE A 358
 None
 1.16A 3ko0A-5m8jA:
undetectable
3ko0C-5m8jA:
0.0		 3ko0A-5m8jA:
11.13
3ko0C-5m8jA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 7 PHE A 114
GLY A 111
PHE A 358
PHE A 239
 None
 1.05A 3ko0D-5m8jA:
undetectable
3ko0E-5m8jA:
undetectable		 3ko0D-5m8jA:
11.13
3ko0E-5m8jA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 10 PHE A 114
GLY A 111
PHE A 358
ILE A 502
PHE A 239
 None
 1.14A 3ko0L-5m8jA:
undetectable
3ko0N-5m8jA:
0.0		 3ko0L-5m8jA:
11.13
3ko0N-5m8jA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 10 ILE A 502
PHE A 239
PHE A 114
GLY A 111
PHE A 358
 None
 1.15A 3ko0R-5m8jA:
0.0
3ko0T-5m8jA:
undetectable		 3ko0R-5m8jA:
11.13
3ko0T-5m8jA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 9 ASN A 310
ALA A 323
LEU A 191
ASN A 316
VAL A 314
 None
 1.19A 3o01A-5m8jA:
undetectable
3o01B-5m8jA:
undetectable		 3o01A-5m8jA:
21.19
3o01B-5m8jA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 10 ASN A 310
ALA A 323
LEU A 191
ASN A 316
VAL A 314
 None
 1.14A 3o02A-5m8jA:
undetectable
3o02B-5m8jA:
undetectable		 3o02A-5m8jA:
21.19
3o02B-5m8jA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 6 LEU A  90
SER A 242
ALA A 243
LEU A 421
 None
 1.05A 3rd0A-5m8jA:
undetectable		 3rd0A-5m8jA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 10 ALA A 133
VAL A 130
GLU A 129
SER A 406
VAL A 380
 None
 1.22A 4da7A-5m8jA:
undetectable		 4da7A-5m8jA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 6 ALA A 236
GLY A  48
LEU A 240
VAL A  45
 None
 1.07A 4dubA-5m8jA:
1.2		 4dubA-5m8jA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 7 ARG A 369
THR A 350
ILE A 122
THR A 372
 None
 0.83A 4eq4A-5m8jA:
undetectable		 4eq4A-5m8jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 8 ARG A 369
THR A 350
ILE A 122
THR A 372
 None
 0.79A 4eq4B-5m8jA:
undetectable		 4eq4B-5m8jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 7 ARG A 369
THR A 350
ILE A 122
THR A 372
 None
 0.78A 4eqlA-5m8jA:
undetectable		 4eqlA-5m8jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 7 ARG A 369
THR A 350
ILE A 122
THR A 372
 None
 0.79A 4eqlB-5m8jA:
undetectable		 4eqlB-5m8jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 8 SER A  56
ASN A  54
MET A 286
GLY A 287
 None
 0.89A 4fo4A-5m8jA:
undetectable		 4fo4A-5m8jA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 7 ARG A 373
SER A 300
VAL A 380
MET A 403
 None
 1.42A 4klaA-5m8jA:
undetectable		 4klaA-5m8jA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 7 ARG A 369
THR A 350
ILE A 122
THR A 372
 None
 0.75A 4l39B-5m8jA:
undetectable		 4l39B-5m8jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 5 VAL A  25
ILE A 233
PRO A  41
THR A 350
 None
 1.30A 4ze1A-5m8jA:
undetectable		 4ze1A-5m8jA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 12 ILE A 122
GLY A 347
THR A 346
ALA A 236
GLU A 119
 None
 1.09A 5hw4A-5m8jA:
undetectable		 5hw4A-5m8jA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 12 ILE A 122
GLY A 347
THR A 346
ALA A 236
GLU A 119
 None
 1.06A 5hw4C-5m8jA:
undetectable		 5hw4C-5m8jA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 8 SER A 343
GLN A 407
ASN A 342
ASP A  51
 None
 1.24A 5vunA-5m8jA:
undetectable		 5vunA-5m8jA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 6 ASN A 405
VAL A 408
LEU A 120
GLN A 463
 None
 1.15A 5xdhA-5m8jA:
0.2
5xdhC-5m8jA:
0.1		 5xdhA-5m8jA:
9.44
5xdhC-5m8jA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		4 / 6 GLN A 463
ASN A 404
VAL A 408
LEU A 120
 None
 1.17A 5xdhA-5m8jA:
0.2
5xdhC-5m8jA:
0.1		 5xdhA-5m8jA:
9.44
5xdhC-5m8jA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 12 ASN A  54
SER A  77
ASN A 280
GLY A  48
ASN A 237
 None
 1.11A 6c79A-5m8jA:
undetectable		 6c79A-5m8jA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 10 ARG A 368
GLY A 357
ARG A 108
SER A 107
VAL A 353
 None
 1.19A 6clxB-5m8jA:
undetectable		 6clxB-5m8jA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 10 PHE A 114
LEU A 117
THR A 118
SER A 417
ILE A 102
 None
 1.20A 6ebpB-5m8jA:
2.8		 6ebpB-5m8jA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH
(Eremococcus
coleocola) 		5 / 10 PHE A 114
LEU A 117
THR A 118
SER A 417
ILE A 102
 None
 1.17A 6ebpC-5m8jA:
3.0		 6ebpC-5m8jA:
8.82