SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 PHE A 362
HIS A 377
HIS A 404
HIS A 381
 None
ZN  A 511 ( 3.2A)
ZN  A 511 (-3.1A)
ZN  A 511 ( 3.3A)
 0.94A 1azmA-5m8tA:
undetectable		 1azmA-5m8tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 PHE A 362
HIS A 377
HIS A 381
HIS A 224
 None
ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
ZN  A 512 (-3.5A)
 0.98A 1bzmA-5m8tA:
undetectable		 1bzmA-5m8tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 PHE A 362
HIS A 377
HIS A 404
HIS A 381
 None
ZN  A 511 ( 3.2A)
ZN  A 511 (-3.1A)
ZN  A 511 ( 3.3A)
 0.91A 1bzmA-5m8tA:
undetectable		 1bzmA-5m8tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 GLU A 413
ARG A 416
ARG A 417
LEU A 337
 None
 0.97A 1cmaA-5m8tA:
undetectable
1cmaB-5m8tA:
undetectable		 1cmaA-5m8tA:
11.42
1cmaB-5m8tA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_A_H4BA700_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 1d1vA-5m8tA:
undetectable
1d1vB-5m8tA:
undetectable		 1d1vA-5m8tA:
21.55
1d1vB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_B_H4BB701_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.02A 1d1vA-5m8tA:
undetectable
1d1vB-5m8tA:
undetectable		 1d1vA-5m8tA:
21.55
1d1vB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 1d1wA-5m8tA:
0.0
1d1wB-5m8tA:
undetectable		 1d1wA-5m8tA:
21.55
1d1wB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_B_H4BB601_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.01A 1d1wA-5m8tA:
0.0
1d1wB-5m8tA:
undetectable		 1d1wA-5m8tA:
21.55
1d1wB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1X_A_H4BA600_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME DOMAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 1d1xA-5m8tA:
undetectable
1d1xB-5m8tA:
undetectable		 1d1xA-5m8tA:
21.55
1d1xB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1X_B_H4BB601_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME DOMAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.00A 1d1xA-5m8tA:
undetectable
1d1xB-5m8tA:
undetectable		 1d1xA-5m8tA:
21.55
1d1xB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_A_H4BA1600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 1dm8A-5m8tA:
0.0
1dm8B-5m8tA:
undetectable		 1dm8A-5m8tA:
21.55
1dm8B-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_B_H4BB2600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.01A 1dm8A-5m8tA:
0.0
1dm8B-5m8tA:
undetectable		 1dm8A-5m8tA:
21.55
1dm8B-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 1dmiA-5m8tA:
undetectable
1dmiB-5m8tA:
undetectable		 1dmiA-5m8tA:
21.55
1dmiB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_B_BHSB2610_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.02A 1dmiA-5m8tA:
undetectable
1dmiB-5m8tA:
undetectable		 1dmiA-5m8tA:
21.55
1dmiB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_A_H4BA1600_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.12A 1fopA-5m8tA:
undetectable
1fopB-5m8tA:
undetectable		 1fopA-5m8tA:
21.55
1fopB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_B_H4BB2600_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 1fopA-5m8tA:
undetectable
1fopB-5m8tA:
undetectable		 1fopA-5m8tA:
21.55
1fopB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 1k2rA-5m8tA:
undetectable
1k2rB-5m8tA:
undetectable		 1k2rA-5m8tA:
19.87
1k2rB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 1k2rA-5m8tA:
undetectable
1k2rB-5m8tA:
undetectable		 1k2rA-5m8tA:
19.87
1k2rB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.01A 1k2sA-5m8tA:
undetectable
1k2sB-5m8tA:
undetectable		 1k2sA-5m8tA:
19.87
1k2sB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.00A 1k2sA-5m8tA:
undetectable
1k2sB-5m8tA:
undetectable		 1k2sA-5m8tA:
19.87
1k2sB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 1k2tA-5m8tA:
undetectable
1k2tB-5m8tA:
undetectable		 1k2tA-5m8tA:
19.87
1k2tB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 1k2tA-5m8tA:
undetectable
1k2tB-5m8tA:
undetectable		 1k2tA-5m8tA:
19.87
1k2tB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2U_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 1k2uA-5m8tA:
undetectable
1k2uB-5m8tA:
undetectable		 1k2uA-5m8tA:
19.87
1k2uB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2U_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 1k2uA-5m8tA:
undetectable
1k2uB-5m8tA:
undetectable		 1k2uA-5m8tA:
19.87
1k2uB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 1lzxA-5m8tA:
undetectable
1lzxB-5m8tA:
undetectable		 1lzxA-5m8tA:
19.87
1lzxB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 1lzxA-5m8tA:
undetectable
1lzxB-5m8tA:
undetectable		 1lzxA-5m8tA:
19.87
1lzxB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 1lzzA-5m8tA:
undetectable
1lzzB-5m8tA:
undetectable		 1lzzA-5m8tA:
19.87
1lzzB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 1lzzA-5m8tA:
0.0
1lzzB-5m8tA:
undetectable		 1lzzA-5m8tA:
19.87
1lzzB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 1m00A-5m8tA:
undetectable
1m00B-5m8tA:
undetectable		 1m00A-5m8tA:
19.87
1m00B-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 1m00A-5m8tA:
undetectable
1m00B-5m8tA:
undetectable		 1m00A-5m8tA:
19.87
1m00B-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 1mmvA-5m8tA:
undetectable
1mmvB-5m8tA:
undetectable		 1mmvA-5m8tA:
19.87
1mmvB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 1mmvA-5m8tA:
undetectable
1mmvB-5m8tA:
undetectable		 1mmvA-5m8tA:
19.87
1mmvB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.01A 1mmwA-5m8tA:
undetectable
1mmwB-5m8tA:
0.3		 1mmwA-5m8tA:
19.87
1mmwB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 1mmwA-5m8tA:
undetectable
1mmwB-5m8tA:
undetectable		 1mmwA-5m8tA:
19.87
1mmwB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 12 PHE A 251
LEU A 403
ALA A 380
LEU A 379
PHE A 342
 None
 1.25A 1mx8A-5m8tA:
undetectable		 1mx8A-5m8tA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ASP A 173
GLY A 174
THR A 176
PRO A 177
 None
 0.36A 1n4fA-5m8tA:
undetectable		 1n4fA-5m8tA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 1nseA-5m8tA:
undetectable
1nseB-5m8tA:
undetectable		 1nseA-5m8tA:
21.55
1nseB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.01A 1nseA-5m8tA:
undetectable
1nseB-5m8tA:
undetectable		 1nseA-5m8tA:
21.55
1nseB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 1nsiA-5m8tA:
undetectable
1nsiB-5m8tA:
undetectable		 1nsiA-5m8tA:
20.32
1nsiB-5m8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 1nsiA-5m8tA:
undetectable
1nsiB-5m8tA:
undetectable		 1nsiA-5m8tA:
20.32
1nsiB-5m8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 1nsiC-5m8tA:
0.0
1nsiD-5m8tA:
undetectable		 1nsiC-5m8tA:
20.32
1nsiD-5m8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 1nsiC-5m8tA:
0.0
1nsiD-5m8tA:
undetectable		 1nsiC-5m8tA:
20.32
1nsiD-5m8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 1om4A-5m8tA:
undetectable
1om4B-5m8tA:
undetectable		 1om4A-5m8tA:
20.00
1om4B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 1om4A-5m8tA:
undetectable
1om4B-5m8tA:
undetectable		 1om4A-5m8tA:
20.00
1om4B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.02A 1om5A-5m8tA:
undetectable
1om5B-5m8tA:
undetectable		 1om5A-5m8tA:
20.08
1om5B-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 1om5A-5m8tA:
undetectable
1om5B-5m8tA:
undetectable		 1om5A-5m8tA:
20.08
1om5B-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 1p6hA-5m8tA:
undetectable
1p6hB-5m8tA:
undetectable		 1p6hA-5m8tA:
20.08
1p6hB-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6H_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 1p6hA-5m8tA:
undetectable
1p6hB-5m8tA:
undetectable		 1p6hA-5m8tA:
20.08
1p6hB-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 1p6iA-5m8tA:
undetectable
1p6iB-5m8tA:
undetectable		 1p6iA-5m8tA:
20.08
1p6iB-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 1p6iA-5m8tA:
undetectable
1p6iB-5m8tA:
undetectable		 1p6iA-5m8tA:
20.08
1p6iB-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6J_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 1p6jA-5m8tA:
undetectable
1p6jB-5m8tA:
undetectable		 1p6jA-5m8tA:
20.08
1p6jB-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6J_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 1p6jA-5m8tA:
undetectable
1p6jB-5m8tA:
undetectable		 1p6jA-5m8tA:
20.08
1p6jB-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 1p6kA-5m8tA:
undetectable
1p6kB-5m8tA:
undetectable		 1p6kA-5m8tA:
20.30
1p6kB-5m8tA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 1p6kA-5m8tA:
undetectable
1p6kB-5m8tA:
undetectable		 1p6kA-5m8tA:
20.30
1p6kB-5m8tA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.11A 1p6lA-5m8tA:
undetectable
1p6lB-5m8tA:
undetectable		 1p6lA-5m8tA:
21.04
1p6lB-5m8tA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 1p6lA-5m8tA:
undetectable
1p6lB-5m8tA:
undetectable		 1p6lA-5m8tA:
21.04
1p6lB-5m8tA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 1p6mA-5m8tA:
undetectable
1p6mB-5m8tA:
undetectable		 1p6mA-5m8tA:
21.04
1p6mB-5m8tA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 1p6mA-5m8tA:
undetectable
1p6mB-5m8tA:
undetectable		 1p6mA-5m8tA:
21.04
1p6mB-5m8tA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 1p6nA-5m8tA:
undetectable
1p6nB-5m8tA:
0.5		 1p6nA-5m8tA:
21.04
1p6nB-5m8tA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 1p6nA-5m8tA:
undetectable
1p6nB-5m8tA:
0.5		 1p6nA-5m8tA:
21.04
1p6nB-5m8tA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 1q2oA-5m8tA:
undetectable
1q2oB-5m8tA:
0.5		 1q2oA-5m8tA:
21.25
1q2oB-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 1q2oA-5m8tA:
undetectable
1q2oB-5m8tA:
0.5		 1q2oA-5m8tA:
21.25
1q2oB-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 1rs6A-5m8tA:
undetectable
1rs6B-5m8tA:
0.3		 1rs6A-5m8tA:
20.08
1rs6B-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 1rs6A-5m8tA:
undetectable
1rs6B-5m8tA:
undetectable		 1rs6A-5m8tA:
20.08
1rs6B-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 1rs7A-5m8tA:
undetectable
1rs7B-5m8tA:
undetectable		 1rs7A-5m8tA:
20.08
1rs7B-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 1rs7A-5m8tA:
undetectable
1rs7B-5m8tA:
undetectable		 1rs7A-5m8tA:
20.08
1rs7B-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.01A 1rs8A-5m8tA:
undetectable
1rs8B-5m8tA:
0.1		 1rs8A-5m8tA:
21.25
1rs8B-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 1rs9A-5m8tA:
0.4
1rs9B-5m8tA:
undetectable		 1rs9A-5m8tA:
21.25
1rs9B-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 1rs9A-5m8tA:
0.4
1rs9B-5m8tA:
undetectable		 1rs9A-5m8tA:
21.25
1rs9B-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVL_A_H4BA900_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 1zvlA-5m8tA:
undetectable
1zvlB-5m8tA:
undetectable		 1zvlA-5m8tA:
20.08
1zvlB-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVL_B_H4BB920_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.14A 1zvlA-5m8tA:
undetectable
1zvlB-5m8tA:
0.0		 1zvlA-5m8tA:
20.08
1zvlB-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 1zzqA-5m8tA:
undetectable
1zzqB-5m8tA:
undetectable		 1zzqA-5m8tA:
20.00
1zzqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 1zzqA-5m8tA:
undetectable
1zzqB-5m8tA:
undetectable		 1zzqA-5m8tA:
20.00
1zzqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 1zzrA-5m8tA:
undetectable
1zzrB-5m8tA:
undetectable		 1zzrA-5m8tA:
20.00
1zzrB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 1zzrA-5m8tA:
undetectable
1zzrB-5m8tA:
undetectable		 1zzrA-5m8tA:
20.00
1zzrB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 1zzsA-5m8tA:
0.3
1zzsB-5m8tA:
undetectable		 1zzsA-5m8tA:
21.25
1zzsB-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 1zzsA-5m8tA:
0.3
1zzsB-5m8tA:
undetectable		 1zzsA-5m8tA:
21.25
1zzsB-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZT_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 1zztA-5m8tA:
0.0
1zztB-5m8tA:
0.0		 1zztA-5m8tA:
21.25
1zztB-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZT_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 1zztA-5m8tA:
0.0
1zztB-5m8tA:
0.0		 1zztA-5m8tA:
21.25
1zztB-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 1zzuA-5m8tA:
0.0
1zzuB-5m8tA:
undetectable		 1zzuA-5m8tA:
20.00
1zzuB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 1zzuA-5m8tA:
0.0
1zzuB-5m8tA:
undetectable		 1zzuA-5m8tA:
20.00
1zzuB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 12 ASN A 385
LEU A 384
VAL A 373
GLY A 361
PRO A 328
 NAG  A 509 (-1.8A)
None
None
None
None
 1.08A 2f8lA-5m8tA:
undetectable		 2f8lA-5m8tA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 2g6hA-5m8tA:
undetectable
2g6hB-5m8tA:
undetectable		 2g6hA-5m8tA:
19.79
2g6hB-5m8tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 2g6hA-5m8tA:
undetectable
2g6hB-5m8tA:
undetectable		 2g6hA-5m8tA:
19.79
2g6hB-5m8tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 2g6kA-5m8tA:
undetectable
2g6kB-5m8tA:
undetectable		 2g6kA-5m8tA:
19.79
2g6kB-5m8tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 2g6kA-5m8tA:
undetectable
2g6kB-5m8tA:
undetectable		 2g6kA-5m8tA:
19.79
2g6kB-5m8tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 2g6mA-5m8tA:
undetectable
2g6mB-5m8tA:
undetectable		 2g6mA-5m8tA:
19.79
2g6mB-5m8tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 2g6mA-5m8tA:
undetectable
2g6mB-5m8tA:
undetectable		 2g6mA-5m8tA:
19.79
2g6mB-5m8tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 2hx2A-5m8tA:
0.0
2hx2B-5m8tA:
undetectable		 2hx2A-5m8tA:
21.25
2hx2B-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 2hx2A-5m8tA:
0.0
2hx2B-5m8tA:
undetectable		 2hx2A-5m8tA:
21.25
2hx2B-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX3_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 2hx3A-5m8tA:
undetectable
2hx3B-5m8tA:
undetectable		 2hx3A-5m8tA:
20.00
2hx3B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX3_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 2hx3A-5m8tA:
undetectable
2hx3B-5m8tA:
undetectable		 2hx3A-5m8tA:
20.00
2hx3B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX4_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 2hx4A-5m8tA:
undetectable
2hx4B-5m8tA:
undetectable		 2hx4A-5m8tA:
20.00
2hx4B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX4_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 2hx4A-5m8tA:
undetectable
2hx4B-5m8tA:
undetectable		 2hx4A-5m8tA:
20.00
2hx4B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 2nseA-5m8tA:
undetectable
2nseB-5m8tA:
undetectable		 2nseA-5m8tA:
21.55
2nseB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.02A 2nseA-5m8tA:
0.0
2nseB-5m8tA:
0.0		 2nseA-5m8tA:
21.55
2nseB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.02A 2nsiA-5m8tA:
undetectable
2nsiB-5m8tA:
undetectable		 2nsiA-5m8tA:
20.32
2nsiB-5m8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.01A 2nsiA-5m8tA:
undetectable
2nsiB-5m8tA:
undetectable		 2nsiA-5m8tA:
20.32
2nsiB-5m8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.01A 2nsiC-5m8tA:
0.0
2nsiD-5m8tA:
undetectable		 2nsiC-5m8tA:
20.32
2nsiD-5m8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.01A 2nsiC-5m8tA:
0.0
2nsiD-5m8tA:
undetectable		 2nsiC-5m8tA:
20.32
2nsiD-5m8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 LEU A 337
LEU A 221
PRO A 328
GLY A 361
 None
 0.92A 2po5A-5m8tA:
undetectable		 2po5A-5m8tA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 PHE A 144
TYR A 248
PRO A 247
TRP A 249
 None
 1.50A 2q6kA-5m8tA:
undetectable		 2q6kA-5m8tA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		3 / 3 VAL A 333
ASN A 250
TRP A 249
 None
 0.84A 2y00B-5m8tA:
undetectable		 2y00B-5m8tA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 VAL A 211
ASP A  82
HIS A  75
TYR A 438
 None
 1.48A 2zs9A-5m8tA:
undetectable		 2zs9A-5m8tA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.29A 2zweA-5m8tA:
28.6
2zweB-5m8tA:
undetectable		 2zweA-5m8tA:
22.12
2zweB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 215
HIS A 192
HIS A 381
HIS A 377
ASP A 408
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
None
 1.48A 2zweA-5m8tA:
28.6
2zweB-5m8tA:
undetectable		 2zweA-5m8tA:
22.12
2zweB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.11A 2zweA-5m8tA:
28.6
2zweB-5m8tA:
undetectable		 2zweA-5m8tA:
22.12
2zweB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.44A 2zweA-5m8tA:
28.6
2zweB-5m8tA:
undetectable		 2zweA-5m8tA:
22.12
2zweB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.34A 2zwfA-5m8tA:
28.6
2zwfB-5m8tA:
undetectable		 2zwfA-5m8tA:
22.12
2zwfB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.40A 2zwfA-5m8tA:
28.6
2zwfB-5m8tA:
undetectable		 2zwfA-5m8tA:
22.12
2zwfB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 215
HIS A 192
HIS A 381
HIS A 377
ASP A 408
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
None
 1.44A 2zwfA-5m8tA:
28.6
2zwfB-5m8tA:
undetectable		 2zwfA-5m8tA:
22.12
2zwfB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.07A 2zwfA-5m8tA:
28.6
2zwfB-5m8tA:
undetectable		 2zwfA-5m8tA:
22.12
2zwfB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.44A 2zwfA-5m8tA:
28.6
2zwfB-5m8tA:
undetectable		 2zwfA-5m8tA:
22.12
2zwfB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.49A 2zwfA-5m8tA:
28.6
2zwfB-5m8tA:
undetectable		 2zwfA-5m8tA:
22.12
2zwfB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.35A 2zwgA-5m8tA:
28.6
2zwgB-5m8tA:
undetectable		 2zwgA-5m8tA:
22.12
2zwgB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 192
HIS A 224
HIS A 377
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.40A 2zwgA-5m8tA:
28.6
2zwgB-5m8tA:
undetectable		 2zwgA-5m8tA:
22.12
2zwgB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.05A 2zwgA-5m8tA:
28.6
2zwgB-5m8tA:
undetectable		 2zwgA-5m8tA:
22.12
2zwgB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.42A 2zwgA-5m8tA:
28.6
2zwgB-5m8tA:
undetectable		 2zwgA-5m8tA:
22.12
2zwgB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.49A 2zwgA-5m8tA:
28.6
2zwgB-5m8tA:
undetectable		 2zwgA-5m8tA:
22.12
2zwgB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 3b3mA-5m8tA:
undetectable
3b3mB-5m8tA:
undetectable		 3b3mA-5m8tA:
20.00
3b3mB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 3b3mA-5m8tA:
undetectable
3b3mB-5m8tA:
undetectable		 3b3mA-5m8tA:
20.00
3b3mB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 3b3nA-5m8tA:
undetectable
3b3nB-5m8tA:
undetectable		 3b3nA-5m8tA:
20.00
3b3nB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 3b3nA-5m8tA:
undetectable
3b3nB-5m8tA:
undetectable		 3b3nA-5m8tA:
20.00
3b3nB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3O_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 3b3oA-5m8tA:
undetectable
3b3oB-5m8tA:
undetectable		 3b3oA-5m8tA:
20.00
3b3oB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3O_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3b3oA-5m8tA:
undetectable
3b3oB-5m8tA:
undetectable		 3b3oA-5m8tA:
20.00
3b3oB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3b3pA-5m8tA:
0.0
3b3pB-5m8tA:
undetectable		 3b3pA-5m8tA:
20.00
3b3pB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 3b3pA-5m8tA:
0.0
3b3pB-5m8tA:
undetectable		 3b3pA-5m8tA:
20.00
3b3pB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 ILE A 311
PRO A 398
PHE A 400
PRO A 395
 None
None
ZN  A 511 ( 4.7A)
None
 1.30A 3bjwC-5m8tA:
0.3		 3bjwC-5m8tA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.01A 3dqrA-5m8tA:
undetectable
3dqrB-5m8tA:
undetectable		 3dqrA-5m8tA:
20.21
3dqrB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3dqrA-5m8tA:
undetectable
3dqrB-5m8tA:
undetectable		 3dqrA-5m8tA:
20.21
3dqrB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3dqsA-5m8tA:
0.5
3dqsB-5m8tA:
undetectable		 3dqsA-5m8tA:
21.25
3dqsB-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 3dqsA-5m8tA:
0.5
3dqsB-5m8tA:
undetectable		 3dqsA-5m8tA:
21.25
3dqsB-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3dqtA-5m8tA:
undetectable
3dqtB-5m8tA:
0.0		 3dqtA-5m8tA:
21.25
3dqtB-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 3dqtA-5m8tA:
undetectable
3dqtB-5m8tA:
undetectable		 3dqtA-5m8tA:
21.25
3dqtB-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 3e7gA-5m8tA:
undetectable
3e7gB-5m8tA:
0.0		 3e7gA-5m8tA:
20.93
3e7gB-5m8tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 3e7gA-5m8tA:
undetectable
3e7gB-5m8tA:
0.0		 3e7gA-5m8tA:
20.93
3e7gB-5m8tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.01A 3e7gC-5m8tA:
0.0
3e7gD-5m8tA:
0.0		 3e7gC-5m8tA:
20.93
3e7gD-5m8tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.02A 3e7gC-5m8tA:
undetectable
3e7gD-5m8tA:
undetectable		 3e7gC-5m8tA:
20.93
3e7gD-5m8tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3fc5A-5m8tA:
undetectable
3fc5B-5m8tA:
0.2		 3fc5A-5m8tA:
20.21
3fc5B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 3fc5A-5m8tA:
undetectable
3fc5B-5m8tA:
0.2		 3fc5A-5m8tA:
20.21
3fc5B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3hsnA-5m8tA:
undetectable
3hsnB-5m8tA:
undetectable		 3hsnA-5m8tA:
20.00
3hsnB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3hsnA-5m8tA:
undetectable
3hsnB-5m8tA:
undetectable		 3hsnA-5m8tA:
20.00
3hsnB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 3hsoA-5m8tA:
undetectable
3hsoB-5m8tA:
undetectable		 3hsoA-5m8tA:
20.00
3hsoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3hsoA-5m8tA:
undetectable
3hsoB-5m8tA:
undetectable		 3hsoA-5m8tA:
20.00
3hsoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 3hspA-5m8tA:
undetectable
3hspB-5m8tA:
undetectable		 3hspA-5m8tA:
20.00
3hspB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 3hspA-5m8tA:
undetectable
3hspB-5m8tA:
undetectable		 3hspA-5m8tA:
20.00
3hspB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 3jt3A-5m8tA:
undetectable
3jt3B-5m8tA:
undetectable		 3jt3A-5m8tA:
20.00
3jt3B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3jt3A-5m8tA:
undetectable
3jt3B-5m8tA:
undetectable		 3jt3A-5m8tA:
20.00
3jt3B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 3jt4A-5m8tA:
0.0
3jt4B-5m8tA:
undetectable		 3jt4A-5m8tA:
20.00
3jt4B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 3jt4A-5m8tA:
0.0
3jt4B-5m8tA:
undetectable		 3jt4A-5m8tA:
20.00
3jt4B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3jt5A-5m8tA:
undetectable
3jt5B-5m8tA:
undetectable		 3jt5A-5m8tA:
20.00
3jt5B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3jt5A-5m8tA:
undetectable
3jt5B-5m8tA:
undetectable		 3jt5A-5m8tA:
20.00
3jt5B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3jt6A-5m8tA:
undetectable
3jt6B-5m8tA:
undetectable		 3jt6A-5m8tA:
20.00
3jt6B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 3jt6A-5m8tA:
undetectable
3jt6B-5m8tA:
undetectable		 3jt6A-5m8tA:
20.00
3jt6B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT7_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3jt7A-5m8tA:
undetectable
3jt7B-5m8tA:
undetectable		 3jt7A-5m8tA:
20.00
3jt7B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT7_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3jt7A-5m8tA:
undetectable
3jt7B-5m8tA:
undetectable		 3jt7A-5m8tA:
20.00
3jt7B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 3jt8A-5m8tA:
undetectable
3jt8B-5m8tA:
undetectable		 3jt8A-5m8tA:
20.00
3jt8B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3jt8A-5m8tA:
undetectable
3jt8B-5m8tA:
undetectable		 3jt8A-5m8tA:
20.00
3jt8B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 3jt9A-5m8tA:
undetectable
3jt9B-5m8tA:
undetectable		 3jt9A-5m8tA:
20.00
3jt9B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 3jt9A-5m8tA:
undetectable
3jt9B-5m8tA:
undetectable		 3jt9A-5m8tA:
20.00
3jt9B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JTA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 3jtaA-5m8tA:
undetectable
3jtaB-5m8tA:
0.0		 3jtaA-5m8tA:
20.00
3jtaB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JTA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 3jtaA-5m8tA:
undetectable
3jtaB-5m8tA:
0.0		 3jtaA-5m8tA:
20.00
3jtaB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 3jwsA-5m8tA:
undetectable
3jwsB-5m8tA:
undetectable		 3jwsA-5m8tA:
22.22
3jwsB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWS_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 3jwsA-5m8tA:
undetectable
3jwsB-5m8tA:
undetectable		 3jwsA-5m8tA:
22.22
3jwsB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 3jwtA-5m8tA:
undetectable
3jwtB-5m8tA:
undetectable		 3jwtA-5m8tA:
22.22
3jwtB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3jwtA-5m8tA:
undetectable
3jwtB-5m8tA:
undetectable		 3jwtA-5m8tA:
22.22
3jwtB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 3jwuA-5m8tA:
undetectable
3jwuB-5m8tA:
undetectable		 3jwuA-5m8tA:
22.22
3jwuB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3jwuA-5m8tA:
undetectable
3jwuB-5m8tA:
undetectable		 3jwuA-5m8tA:
22.22
3jwuB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3jwvA-5m8tA:
undetectable
3jwvB-5m8tA:
undetectable		 3jwvA-5m8tA:
22.22
3jwvB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3jwvA-5m8tA:
undetectable
3jwvB-5m8tA:
undetectable		 3jwvA-5m8tA:
22.22
3jwvB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWW_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3jwwA-5m8tA:
0.0
3jwwB-5m8tA:
0.0		 3jwwA-5m8tA:
21.55
3jwwB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 3jwxA-5m8tA:
0.0
3jwxB-5m8tA:
0.5		 3jwxA-5m8tA:
21.55
3jwxB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3jwxA-5m8tA:
0.0
3jwxB-5m8tA:
0.5		 3jwxA-5m8tA:
21.55
3jwxB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3jwyA-5m8tA:
0.0
3jwyB-5m8tA:
0.3		 3jwyA-5m8tA:
21.55
3jwyB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3jwyA-5m8tA:
0.0
3jwyB-5m8tA:
0.3		 3jwyA-5m8tA:
21.55
3jwyB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3jwzA-5m8tA:
0.5
3jwzB-5m8tA:
undetectable		 3jwzA-5m8tA:
21.55
3jwzB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 3jwzA-5m8tA:
0.5
3jwzB-5m8tA:
undetectable		 3jwzA-5m8tA:
21.55
3jwzB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 3jx0A-5m8tA:
undetectable
3jx0B-5m8tA:
undetectable		 3jx0A-5m8tA:
20.21
3jx0B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3jx0A-5m8tA:
undetectable
3jx0B-5m8tA:
undetectable		 3jx0A-5m8tA:
20.21
3jx0B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3jx1A-5m8tA:
0.0
3jx1B-5m8tA:
undetectable		 3jx1A-5m8tA:
20.21
3jx1B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3jx1A-5m8tA:
undetectable
3jx1B-5m8tA:
undetectable		 3jx1A-5m8tA:
20.21
3jx1B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 3jx2A-5m8tA:
undetectable
3jx2B-5m8tA:
undetectable		 3jx2A-5m8tA:
20.21
3jx2B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3jx2A-5m8tA:
undetectable
3jx2B-5m8tA:
undetectable		 3jx2A-5m8tA:
20.21
3jx2B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3jx3A-5m8tA:
0.0
3jx3B-5m8tA:
undetectable		 3jx3A-5m8tA:
20.21
3jx3B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3jx3A-5m8tA:
0.0
3jx3B-5m8tA:
undetectable		 3jx3A-5m8tA:
20.21
3jx3B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 3jx4A-5m8tA:
undetectable
3jx4B-5m8tA:
undetectable		 3jx4A-5m8tA:
20.21
3jx4B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 3jx5A-5m8tA:
undetectable
3jx5B-5m8tA:
undetectable		 3jx5A-5m8tA:
20.21
3jx5B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 3jx5A-5m8tA:
undetectable
3jx5B-5m8tA:
undetectable		 3jx5A-5m8tA:
20.21
3jx5B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.02A 3jx6A-5m8tA:
undetectable
3jx6B-5m8tA:
undetectable		 3jx6A-5m8tA:
20.21
3jx6B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 3jx6A-5m8tA:
undetectable
3jx6B-5m8tA:
undetectable		 3jx6A-5m8tA:
20.21
3jx6B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TYR A 185
GLU A 307
TRP A 286
LEU A 148
 None
 1.29A 3k8mB-5m8tA:
undetectable		 3k8mB-5m8tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 12 SER A 245
LEU A 265
ILE A 260
LEU A 134
ASP A 135
 None
 1.26A 3ko0G-5m8tA:
undetectable
3ko0H-5m8tA:
undetectable
3ko0I-5m8tA:
undetectable
3ko0J-5m8tA:
undetectable		 3ko0G-5m8tA:
16.01
3ko0H-5m8tA:
16.01
3ko0I-5m8tA:
16.01
3ko0J-5m8tA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TYR A 185
LEU A 148
ASP A 149
LYS A 152
 None
 1.27A 3lslA-5m8tA:
undetectable
3lslD-5m8tA:
undetectable		 3lslA-5m8tA:
20.80
3lslD-5m8tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TYR A 185
LEU A 148
ASP A 149
LYS A 152
 None
 1.34A 3lslA-5m8tA:
undetectable
3lslD-5m8tA:
undetectable		 3lslA-5m8tA:
20.80
3lslD-5m8tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TYR A 185
LEU A 148
ASP A 149
LYS A 152
 None
 1.34A 3lslG-5m8tA:
undetectable		 3lslG-5m8tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3n2rA-5m8tA:
undetectable
3n2rB-5m8tA:
undetectable		 3n2rA-5m8tA:
20.00
3n2rB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3n2rA-5m8tA:
undetectable
3n2rB-5m8tA:
undetectable		 3n2rA-5m8tA:
20.00
3n2rB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.12A 3n5pA-5m8tA:
0.3
3n5pB-5m8tA:
undetectable		 3n5pA-5m8tA:
21.55
3n5pB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Q_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3n5qA-5m8tA:
undetectable
3n5qB-5m8tA:
0.2		 3n5qA-5m8tA:
21.55
3n5qB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 3n5rA-5m8tA:
undetectable
3n5rB-5m8tA:
undetectable		 3n5rA-5m8tA:
21.55
3n5rB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3n5rA-5m8tA:
undetectable
3n5rB-5m8tA:
undetectable		 3n5rA-5m8tA:
21.55
3n5rB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3n5sA-5m8tA:
0.5
3n5sB-5m8tA:
0.5		 3n5sA-5m8tA:
21.55
3n5sB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.11A 3n5sA-5m8tA:
0.5
3n5sB-5m8tA:
0.5		 3n5sA-5m8tA:
21.55
3n5sB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.11A 3n5tA-5m8tA:
undetectable
3n5tB-5m8tA:
undetectable		 3n5tA-5m8tA:
21.55
3n5tB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.12A 3n5tA-5m8tA:
undetectable
3n5tB-5m8tA:
undetectable		 3n5tA-5m8tA:
21.55
3n5tB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3n5vA-5m8tA:
undetectable
3n5vB-5m8tA:
undetectable		 3n5vA-5m8tA:
20.00
3n5vB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3n5vA-5m8tA:
undetectable
3n5vB-5m8tA:
undetectable		 3n5vA-5m8tA:
20.00
3n5vB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3n5yA-5m8tA:
0.0
3n5yB-5m8tA:
undetectable		 3n5yA-5m8tA:
20.00
3n5yB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3n5yA-5m8tA:
undetectable
3n5yB-5m8tA:
undetectable		 3n5yA-5m8tA:
20.00
3n5yB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3n5zA-5m8tA:
undetectable
3n5zB-5m8tA:
undetectable		 3n5zA-5m8tA:
20.00
3n5zB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3n5zA-5m8tA:
undetectable
3n5zB-5m8tA:
undetectable		 3n5zA-5m8tA:
20.00
3n5zB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N67_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3n67A-5m8tA:
0.0
3n67B-5m8tA:
undetectable		 3n67A-5m8tA:
21.61
3n67B-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N67_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3n67A-5m8tA:
0.0
3n67B-5m8tA:
0.0		 3n67A-5m8tA:
21.61
3n67B-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N68_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.14A 3n68A-5m8tA:
0.0
3n68B-5m8tA:
0.0		 3n68A-5m8tA:
21.61
3n68B-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N69_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3n69A-5m8tA:
0.0
3n69B-5m8tA:
0.0		 3n69A-5m8tA:
21.61
3n69B-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N69_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3n69A-5m8tA:
0.0
3n69B-5m8tA:
0.0		 3n69A-5m8tA:
21.61
3n69B-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 3n6aA-5m8tA:
0.0
3n6aB-5m8tA:
0.0		 3n6aA-5m8tA:
21.61
3n6aB-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3n6aA-5m8tA:
undetectable
3n6aB-5m8tA:
undetectable		 3n6aA-5m8tA:
21.61
3n6aB-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3n6eA-5m8tA:
undetectable
3n6eB-5m8tA:
0.0		 3n6eA-5m8tA:
21.61
3n6eB-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3n6eA-5m8tA:
undetectable
3n6eB-5m8tA:
0.0		 3n6eA-5m8tA:
21.61
3n6eB-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_A_H4BA600_1
('NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3n6fA-5m8tA:
undetectable
3n6fB-5m8tA:
0.5		 3n6fA-5m8tA:
21.61
3n6fB-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_B_H4BB600_1
('NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3n6fA-5m8tA:
undetectable
3n6fB-5m8tA:
0.5		 3n6fA-5m8tA:
21.61
3n6fB-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3n6gA-5m8tA:
undetectable
3n6gB-5m8tA:
undetectable		 3n6gA-5m8tA:
21.61
3n6gB-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.12A 3n6gA-5m8tA:
undetectable
3n6gB-5m8tA:
undetectable		 3n6gA-5m8tA:
21.61
3n6gB-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLD_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.23A 3nldA-5m8tA:
undetectable
3nldB-5m8tA:
0.0		 3nldA-5m8tA:
21.55
3nldB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 3nleA-5m8tA:
0.5
3nleB-5m8tA:
0.5		 3nleA-5m8tA:
21.55
3nleB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 3nleA-5m8tA:
0.5
3nleB-5m8tA:
0.5		 3nleA-5m8tA:
21.55
3nleB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLF_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3nlfA-5m8tA:
undetectable
3nlfB-5m8tA:
0.5		 3nlfA-5m8tA:
21.55
3nlfB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3nlgA-5m8tA:
0.0
3nlgB-5m8tA:
0.0		 3nlgA-5m8tA:
21.55
3nlgB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 3nlgA-5m8tA:
0.0
3nlgB-5m8tA:
0.0		 3nlgA-5m8tA:
21.55
3nlgB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLH_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 3nlhA-5m8tA:
undetectable
3nlhB-5m8tA:
0.5		 3nlhA-5m8tA:
21.61
3nlhB-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLH_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3nlhA-5m8tA:
undetectable
3nlhB-5m8tA:
0.5		 3nlhA-5m8tA:
21.61
3nlhB-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLI_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3nliA-5m8tA:
0.3
3nliB-5m8tA:
undetectable		 3nliA-5m8tA:
21.61
3nliB-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLI_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3nliA-5m8tA:
0.3
3nliB-5m8tA:
undetectable		 3nliA-5m8tA:
21.61
3nliB-5m8tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.01A 3nljA-5m8tA:
undetectable
3nljB-5m8tA:
undetectable		 3nljA-5m8tA:
20.21
3nljB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3nljA-5m8tA:
undetectable
3nljB-5m8tA:
undetectable		 3nljA-5m8tA:
20.21
3nljB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLK_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3nlkA-5m8tA:
undetectable
3nlkB-5m8tA:
undetectable		 3nlkA-5m8tA:
22.22
3nlkB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3nlkA-5m8tA:
undetectable
3nlkB-5m8tA:
undetectable		 3nlkA-5m8tA:
22.22
3nlkB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3nlmA-5m8tA:
undetectable
3nlmB-5m8tA:
undetectable		 3nlmA-5m8tA:
20.00
3nlmB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3nlmA-5m8tA:
undetectable
3nlmB-5m8tA:
undetectable		 3nlmA-5m8tA:
20.00
3nlmB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3nlnA-5m8tA:
undetectable
3nlnB-5m8tA:
undetectable		 3nlnA-5m8tA:
22.22
3nlnB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 3nlnA-5m8tA:
undetectable
3nlnB-5m8tA:
undetectable		 3nlnA-5m8tA:
22.22
3nlnB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 3nloA-5m8tA:
undetectable
3nloB-5m8tA:
undetectable		 3nloA-5m8tA:
22.22
3nloB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3nloA-5m8tA:
undetectable
3nloB-5m8tA:
undetectable		 3nloA-5m8tA:
22.22
3nloB-5m8tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 3nlpA-5m8tA:
undetectable
3nlpB-5m8tA:
undetectable		 3nlpA-5m8tA:
20.21
3nlpB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3nlpA-5m8tA:
undetectable
3nlpB-5m8tA:
undetectable		 3nlpA-5m8tA:
20.21
3nlpB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.00A 3nlqA-5m8tA:
undetectable
3nlqB-5m8tA:
undetectable		 3nlqA-5m8tA:
20.21
3nlqB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 3nlqA-5m8tA:
undetectable
3nlqB-5m8tA:
undetectable		 3nlqA-5m8tA:
20.21
3nlqB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 3nlrA-5m8tA:
undetectable
3nlrB-5m8tA:
undetectable		 3nlrA-5m8tA:
20.21
3nlrB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3nlrA-5m8tA:
undetectable
3nlrB-5m8tA:
undetectable		 3nlrA-5m8tA:
20.21
3nlrB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLT_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3nltA-5m8tA:
0.0
3nltB-5m8tA:
0.0		 3nltA-5m8tA:
21.55
3nltB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLU_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 3nluA-5m8tA:
undetectable
3nluB-5m8tA:
0.5		 3nluA-5m8tA:
21.55
3nluB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLU_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.13A 3nluA-5m8tA:
0.0
3nluB-5m8tA:
0.0		 3nluA-5m8tA:
21.55
3nluB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3nlvA-5m8tA:
undetectable
3nlvB-5m8tA:
undetectable		 3nlvA-5m8tA:
20.00
3nlvB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3nlvA-5m8tA:
undetectable
3nlvB-5m8tA:
undetectable		 3nlvA-5m8tA:
20.00
3nlvB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3nlwA-5m8tA:
undetectable
3nlwB-5m8tA:
undetectable		 3nlwA-5m8tA:
20.00
3nlwB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3nlwA-5m8tA:
undetectable
3nlwB-5m8tA:
undetectable		 3nlwA-5m8tA:
20.00
3nlwB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 3nlxA-5m8tA:
undetectable
3nlxB-5m8tA:
undetectable		 3nlxA-5m8tA:
20.00
3nlxB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3nlxA-5m8tA:
undetectable
3nlxB-5m8tA:
undetectable		 3nlxA-5m8tA:
20.00
3nlxB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 3nlyA-5m8tA:
undetectable
3nlyB-5m8tA:
undetectable		 3nlyA-5m8tA:
20.00
3nlyB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3nlyA-5m8tA:
undetectable
3nlyB-5m8tA:
undetectable		 3nlyA-5m8tA:
20.00
3nlyB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3nlzA-5m8tA:
undetectable
3nlzB-5m8tA:
undetectable		 3nlzA-5m8tA:
20.00
3nlzB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3nlzA-5m8tA:
undetectable
3nlzB-5m8tA:
undetectable		 3nlzA-5m8tA:
20.00
3nlzB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NM0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3nm0A-5m8tA:
undetectable
3nm0B-5m8tA:
undetectable		 3nm0A-5m8tA:
20.00
3nm0B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NM0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3nm0A-5m8tA:
undetectable
3nm0B-5m8tA:
undetectable		 3nm0A-5m8tA:
20.00
3nm0B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNY_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 3nnyA-5m8tA:
undetectable
3nnyB-5m8tA:
undetectable		 3nnyA-5m8tA:
20.00
3nnyB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.11A 3nnyA-5m8tA:
undetectable
3nnyB-5m8tA:
undetectable		 3nnyA-5m8tA:
20.00
3nnyB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3nnzA-5m8tA:
undetectable
3nnzB-5m8tA:
undetectable		 3nnzA-5m8tA:
20.00
3nnzB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3nnzA-5m8tA:
undetectable
3nnzB-5m8tA:
undetectable		 3nnzA-5m8tA:
20.00
3nnzB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_A_H4BA511_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3nosA-5m8tA:
0.1
3nosB-5m8tA:
0.2		 3nosA-5m8tA:
20.66
3nosB-5m8tA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_B_H4BB1011_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.12A 3nosA-5m8tA:
0.1
3nosB-5m8tA:
0.2		 3nosA-5m8tA:
20.66
3nosB-5m8tA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3pneA-5m8tA:
undetectable
3pneB-5m8tA:
undetectable		 3pneA-5m8tA:
20.00
3pneB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3pneA-5m8tA:
undetectable
3pneB-5m8tA:
undetectable		 3pneA-5m8tA:
20.00
3pneB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3pnfA-5m8tA:
undetectable
3pnfB-5m8tA:
undetectable		 3pnfA-5m8tA:
20.00
3pnfB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNF_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3pnfA-5m8tA:
undetectable
3pnfB-5m8tA:
undetectable		 3pnfA-5m8tA:
20.00
3pnfB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3pngA-5m8tA:
undetectable
3pngB-5m8tA:
undetectable		 3pngA-5m8tA:
20.00
3pngB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNG_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3pngA-5m8tA:
undetectable
3pngB-5m8tA:
undetectable		 3pngA-5m8tA:
20.00
3pngB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNH_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 3pnhA-5m8tA:
0.5
3pnhB-5m8tA:
0.4		 3pnhA-5m8tA:
21.25
3pnhB-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNH_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3pnhA-5m8tA:
0.5
3pnhB-5m8tA:
0.4		 3pnhA-5m8tA:
21.25
3pnhB-5m8tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q99_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3q99A-5m8tA:
undetectable
3q99B-5m8tA:
undetectable		 3q99A-5m8tA:
20.00
3q99B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q99_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3q99A-5m8tA:
undetectable
3q99B-5m8tA:
undetectable		 3q99A-5m8tA:
20.00
3q99B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q9A_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3q9aA-5m8tA:
undetectable
3q9aB-5m8tA:
undetectable		 3q9aA-5m8tA:
20.00
3q9aB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q9A_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 3q9aA-5m8tA:
undetectable
3q9aB-5m8tA:
undetectable		 3q9aA-5m8tA:
20.00
3q9aB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 215
HIS A 224
HIS A 192
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
 0.36A 3qpkA-5m8tA:
undetectable		 3qpkA-5m8tA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 215
HIS A 224
HIS A 192
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
 0.33A 3qpkB-5m8tA:
undetectable		 3qpkB-5m8tA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3rqjA-5m8tA:
undetectable
3rqjB-5m8tA:
undetectable		 3rqjA-5m8tA:
20.00
3rqjB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQJ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3rqjA-5m8tA:
undetectable
3rqjB-5m8tA:
undetectable		 3rqjA-5m8tA:
20.00
3rqjB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQK_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3rqkA-5m8tA:
0.0
3rqkB-5m8tA:
0.0		 3rqkA-5m8tA:
20.00
3rqkB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 3rqkA-5m8tA:
undetectable
3rqkB-5m8tA:
undetectable		 3rqkA-5m8tA:
20.00
3rqkB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 3rqlA-5m8tA:
undetectable
3rqlB-5m8tA:
undetectable		 3rqlA-5m8tA:
20.00
3rqlB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3rqlA-5m8tA:
undetectable
3rqlB-5m8tA:
undetectable		 3rqlA-5m8tA:
20.00
3rqlB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 3rqmA-5m8tA:
undetectable
3rqmB-5m8tA:
undetectable		 3rqmA-5m8tA:
20.00
3rqmB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3rqmA-5m8tA:
undetectable
3rqmB-5m8tA:
undetectable		 3rqmA-5m8tA:
20.00
3rqmB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3rqnA-5m8tA:
undetectable
3rqnB-5m8tA:
undetectable		 3rqnA-5m8tA:
20.00
3rqnB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 3rqnA-5m8tA:
undetectable
3rqnB-5m8tA:
undetectable		 3rqnA-5m8tA:
20.00
3rqnB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQO_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3rqoA-5m8tA:
undetectable
3rqoB-5m8tA:
undetectable		 3rqoA-5m8tA:
21.75
3rqoB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQO_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 3rqoA-5m8tA:
undetectable
3rqoB-5m8tA:
undetectable		 3rqoA-5m8tA:
21.75
3rqoB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQP_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 3rqpA-5m8tA:
undetectable
3rqpB-5m8tA:
0.0		 3rqpA-5m8tA:
21.75
3rqpB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 3svpA-5m8tA:
undetectable
3svpB-5m8tA:
undetectable		 3svpA-5m8tA:
20.00
3svpB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3svpA-5m8tA:
undetectable
3svpB-5m8tA:
undetectable		 3svpA-5m8tA:
20.00
3svpB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.02A 3svqA-5m8tA:
undetectable
3svqB-5m8tA:
undetectable		 3svqA-5m8tA:
20.00
3svqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 3svqA-5m8tA:
undetectable
3svqB-5m8tA:
undetectable		 3svqA-5m8tA:
20.00
3svqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3tylA-5m8tA:
undetectable
3tylB-5m8tA:
undetectable		 3tylA-5m8tA:
20.00
3tylB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 3tylA-5m8tA:
undetectable
3tylB-5m8tA:
undetectable		 3tylA-5m8tA:
20.00
3tylB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3tymA-5m8tA:
undetectable
3tymB-5m8tA:
undetectable		 3tymA-5m8tA:
20.00
3tymB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3tymA-5m8tA:
undetectable
3tymB-5m8tA:
undetectable		 3tymA-5m8tA:
20.00
3tymB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3tynA-5m8tA:
undetectable
3tynB-5m8tA:
undetectable		 3tynA-5m8tA:
20.00
3tynB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.11A 3tynA-5m8tA:
undetectable
3tynB-5m8tA:
undetectable		 3tynA-5m8tA:
20.00
3tynB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3tyoA-5m8tA:
undetectable
3tyoB-5m8tA:
undetectable		 3tyoA-5m8tA:
20.00
3tyoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.11A 3tyoA-5m8tA:
undetectable
3tyoB-5m8tA:
undetectable		 3tyoA-5m8tA:
20.00
3tyoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3ufoA-5m8tA:
undetectable
3ufoB-5m8tA:
undetectable		 3ufoA-5m8tA:
20.00
3ufoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 3ufoA-5m8tA:
undetectable
3ufoB-5m8tA:
undetectable		 3ufoA-5m8tA:
20.00
3ufoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3ufpA-5m8tA:
undetectable
3ufpB-5m8tA:
undetectable		 3ufpA-5m8tA:
20.00
3ufpB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3ufpA-5m8tA:
undetectable
3ufpB-5m8tA:
undetectable		 3ufpA-5m8tA:
20.00
3ufpB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3ufqA-5m8tA:
undetectable
3ufqB-5m8tA:
0.0		 3ufqA-5m8tA:
20.00
3ufqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 3ufqA-5m8tA:
undetectable
3ufqB-5m8tA:
0.0		 3ufqA-5m8tA:
20.00
3ufqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 3ufrA-5m8tA:
undetectable
3ufrB-5m8tA:
undetectable		 3ufrA-5m8tA:
20.00
3ufrB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3ufrA-5m8tA:
undetectable
3ufrB-5m8tA:
undetectable		 3ufrA-5m8tA:
20.00
3ufrB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 3ufsA-5m8tA:
undetectable
3ufsB-5m8tA:
undetectable		 3ufsA-5m8tA:
20.00
3ufsB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3ufsA-5m8tA:
undetectable
3ufsB-5m8tA:
undetectable		 3ufsA-5m8tA:
20.00
3ufsB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3uftA-5m8tA:
undetectable
3uftB-5m8tA:
undetectable		 3uftA-5m8tA:
20.00
3uftB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 3uftA-5m8tA:
undetectable
3uftB-5m8tA:
undetectable		 3uftA-5m8tA:
20.00
3uftB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 3ufuA-5m8tA:
undetectable
3ufuB-5m8tA:
undetectable		 3ufuA-5m8tA:
20.00
3ufuB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 3ufuA-5m8tA:
undetectable
3ufuB-5m8tA:
undetectable		 3ufuA-5m8tA:
20.00
3ufuB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 3ufvA-5m8tA:
undetectable
3ufvB-5m8tA:
undetectable		 3ufvA-5m8tA:
20.00
3ufvB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 3ufvA-5m8tA:
undetectable
3ufvB-5m8tA:
undetectable		 3ufvA-5m8tA:
20.00
3ufvB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 3ufwA-5m8tA:
0.0
3ufwB-5m8tA:
undetectable		 3ufwA-5m8tA:
20.00
3ufwB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 3ufwA-5m8tA:
0.0
3ufwB-5m8tA:
undetectable		 3ufwA-5m8tA:
20.00
3ufwB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		3 / 3 TRP A  90
TRP A 444
THR A  98
 None
 1.49A 4bboB-5m8tA:
undetectable		 4bboB-5m8tA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 HIS A 404
HIS A 215
SER A 214
ASP A 234
 ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
None
None
 1.38A 4blvA-5m8tA:
undetectable		 4blvA-5m8tA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4c39A-5m8tA:
undetectable
4c39B-5m8tA:
undetectable		 4c39A-5m8tA:
20.00
4c39B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.11A 4c39A-5m8tA:
0.0
4c39B-5m8tA:
undetectable		 4c39A-5m8tA:
20.00
4c39B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4c3aA-5m8tA:
undetectable
4c3aB-5m8tA:
undetectable		 4c3aA-5m8tA:
21.75
4c3aB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4c3aA-5m8tA:
undetectable
4c3aB-5m8tA:
undetectable		 4c3aA-5m8tA:
21.75
4c3aB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4camA-5m8tA:
undetectable
4camB-5m8tA:
undetectable		 4camA-5m8tA:
20.00
4camB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4camA-5m8tA:
undetectable
4camB-5m8tA:
undetectable		 4camA-5m8tA:
20.00
4camB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4canA-5m8tA:
undetectable
4canB-5m8tA:
undetectable		 4canA-5m8tA:
20.00
4canB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4canA-5m8tA:
undetectable
4canB-5m8tA:
undetectable		 4canA-5m8tA:
20.00
4canB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4caoA-5m8tA:
undetectable
4caoB-5m8tA:
0.0		 4caoA-5m8tA:
20.00
4caoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.11A 4caoA-5m8tA:
undetectable
4caoB-5m8tA:
0.0		 4caoA-5m8tA:
20.00
4caoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 4capA-5m8tA:
undetectable
4capB-5m8tA:
undetectable		 4capA-5m8tA:
20.00
4capB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4capA-5m8tA:
undetectable
4capB-5m8tA:
undetectable		 4capA-5m8tA:
20.00
4capB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4caqA-5m8tA:
undetectable
4caqB-5m8tA:
undetectable		 4caqA-5m8tA:
20.00
4caqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4caqA-5m8tA:
undetectable
4caqB-5m8tA:
undetectable		 4caqA-5m8tA:
20.00
4caqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4carA-5m8tA:
undetectable
4carB-5m8tA:
undetectable		 4carA-5m8tA:
21.75
4carB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4carA-5m8tA:
undetectable
4carB-5m8tA:
undetectable		 4carA-5m8tA:
21.75
4carB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CDT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4cdtA-5m8tA:
undetectable
4cdtB-5m8tA:
undetectable		 4cdtA-5m8tA:
20.00
4cdtB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CDT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4cdtA-5m8tA:
undetectable
4cdtB-5m8tA:
undetectable		 4cdtA-5m8tA:
20.00
4cdtB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4cftA-5m8tA:
undetectable
4cftB-5m8tA:
0.0		 4cftA-5m8tA:
21.75
4cftB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 4cftA-5m8tA:
undetectable
4cftB-5m8tA:
0.0		 4cftA-5m8tA:
21.75
4cftB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4ctpA-5m8tA:
undetectable
4ctpB-5m8tA:
undetectable		 4ctpA-5m8tA:
20.00
4ctpB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 4ctpA-5m8tA:
undetectable
4ctpB-5m8tA:
undetectable		 4ctpA-5m8tA:
20.00
4ctpB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4ctqA-5m8tA:
0.0
4ctqB-5m8tA:
undetectable		 4ctqA-5m8tA:
20.00
4ctqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.12A 4ctqA-5m8tA:
undetectable
4ctqB-5m8tA:
undetectable		 4ctqA-5m8tA:
20.00
4ctqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4ctrA-5m8tA:
undetectable
4ctrB-5m8tA:
undetectable		 4ctrA-5m8tA:
20.00
4ctrB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 4ctrA-5m8tA:
undetectable
4ctrB-5m8tA:
undetectable		 4ctrA-5m8tA:
20.00
4ctrB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4cttA-5m8tA:
undetectable
4cttB-5m8tA:
undetectable		 4cttA-5m8tA:
20.00
4cttB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 4cttA-5m8tA:
undetectable
4cttB-5m8tA:
undetectable		 4cttA-5m8tA:
20.00
4cttB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4ctuA-5m8tA:
undetectable
4ctuB-5m8tA:
undetectable		 4ctuA-5m8tA:
20.00
4ctuB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4ctuA-5m8tA:
undetectable
4ctuB-5m8tA:
undetectable		 4ctuA-5m8tA:
20.00
4ctuB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_A_H4BA1718_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 4ctvA-5m8tA:
undetectable
4ctvB-5m8tA:
undetectable		 4ctvA-5m8tA:
20.00
4ctvB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4ctvA-5m8tA:
undetectable
4ctvB-5m8tA:
undetectable		 4ctvA-5m8tA:
20.00
4ctvB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_A_H4BA1718_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4ctwA-5m8tA:
undetectable
4ctwB-5m8tA:
undetectable		 4ctwA-5m8tA:
20.00
4ctwB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4ctwA-5m8tA:
undetectable
4ctwB-5m8tA:
undetectable		 4ctwA-5m8tA:
20.00
4ctwB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4ctxA-5m8tA:
undetectable
4ctxB-5m8tA:
undetectable		 4ctxA-5m8tA:
20.00
4ctxB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4ctxA-5m8tA:
undetectable
4ctxB-5m8tA:
undetectable		 4ctxA-5m8tA:
20.00
4ctxB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4ctyA-5m8tA:
undetectable
4ctyB-5m8tA:
0.5		 4ctyA-5m8tA:
21.75
4ctyB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4ctyA-5m8tA:
undetectable
4ctyB-5m8tA:
0.5		 4ctyA-5m8tA:
21.75
4ctyB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4ctzA-5m8tA:
undetectable
4ctzB-5m8tA:
undetectable		 4ctzA-5m8tA:
21.75
4ctzB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4ctzA-5m8tA:
undetectable
4ctzB-5m8tA:
undetectable		 4ctzA-5m8tA:
21.75
4ctzB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4cu0A-5m8tA:
0.0
4cu0B-5m8tA:
0.3		 4cu0A-5m8tA:
21.75
4cu0B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4cu0A-5m8tA:
0.0
4cu0B-5m8tA:
0.3		 4cu0A-5m8tA:
21.75
4cu0B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4cu1A-5m8tA:
0.5
4cu1B-5m8tA:
undetectable		 4cu1A-5m8tA:
21.75
4cu1B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4cu1A-5m8tA:
0.5
4cu1B-5m8tA:
undetectable		 4cu1A-5m8tA:
21.75
4cu1B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4cwvA-5m8tA:
undetectable
4cwvB-5m8tA:
0.6		 4cwvA-5m8tA:
21.75
4cwvB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 4cwvA-5m8tA:
undetectable
4cwvB-5m8tA:
0.6		 4cwvA-5m8tA:
21.75
4cwvB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4cwwA-5m8tA:
undetectable
4cwwB-5m8tA:
undetectable		 4cwwA-5m8tA:
21.75
4cwwB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4cwwA-5m8tA:
undetectable
4cwwB-5m8tA:
undetectable		 4cwwA-5m8tA:
21.75
4cwwB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 4cwxA-5m8tA:
undetectable
4cwxB-5m8tA:
0.4		 4cwxA-5m8tA:
21.75
4cwxB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4cwxA-5m8tA:
undetectable
4cwxB-5m8tA:
undetectable		 4cwxA-5m8tA:
21.75
4cwxB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4cwyA-5m8tA:
undetectable
4cwyB-5m8tA:
0.5		 4cwyA-5m8tA:
21.75
4cwyB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4cwyA-5m8tA:
0.5
4cwyB-5m8tA:
0.5		 4cwyA-5m8tA:
21.75
4cwyB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4cwzA-5m8tA:
undetectable
4cwzB-5m8tA:
undetectable		 4cwzA-5m8tA:
21.90
4cwzB-5m8tA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 4cwzA-5m8tA:
undetectable
4cwzB-5m8tA:
undetectable		 4cwzA-5m8tA:
21.90
4cwzB-5m8tA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4cx0A-5m8tA:
undetectable
4cx0B-5m8tA:
0.5		 4cx0A-5m8tA:
21.90
4cx0B-5m8tA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4cx0A-5m8tA:
undetectable
4cx0B-5m8tA:
0.5		 4cx0A-5m8tA:
21.90
4cx0B-5m8tA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 4cx3A-5m8tA:
0.0
4cx3B-5m8tA:
undetectable		 4cx3A-5m8tA:
20.21
4cx3B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4cx3A-5m8tA:
0.0
4cx3B-5m8tA:
undetectable		 4cx3A-5m8tA:
20.21
4cx3B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4cx4A-5m8tA:
0.0
4cx4B-5m8tA:
undetectable		 4cx4A-5m8tA:
20.21
4cx4B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 4cx4A-5m8tA:
0.0
4cx4B-5m8tA:
undetectable		 4cx4A-5m8tA:
20.21
4cx4B-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4cx5A-5m8tA:
undetectable
4cx5B-5m8tA:
undetectable		 4cx5A-5m8tA:
20.00
4cx5B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 4cx5A-5m8tA:
undetectable
4cx5B-5m8tA:
undetectable		 4cx5A-5m8tA:
20.00
4cx5B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4cx6A-5m8tA:
undetectable
4cx6B-5m8tA:
undetectable		 4cx6A-5m8tA:
20.00
4cx6B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 4cx6A-5m8tA:
undetectable
4cx6B-5m8tA:
undetectable		 4cx6A-5m8tA:
20.00
4cx6B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4cx7A-5m8tA:
undetectable
4cx7B-5m8tA:
undetectable		 4cx7A-5m8tA:
20.32
4cx7B-5m8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4cx7A-5m8tA:
undetectable
4cx7B-5m8tA:
undetectable		 4cx7A-5m8tA:
20.32
4cx7B-5m8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4cx7C-5m8tA:
undetectable
4cx7D-5m8tA:
undetectable		 4cx7C-5m8tA:
20.32
4cx7D-5m8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.11A 4cx7C-5m8tA:
undetectable
4cx7D-5m8tA:
0.0		 4cx7C-5m8tA:
20.32
4cx7D-5m8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4d1nA-5m8tA:
undetectable
4d1nB-5m8tA:
undetectable		 4d1nA-5m8tA:
20.25
4d1nB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4d1nA-5m8tA:
undetectable
4d1nB-5m8tA:
undetectable		 4d1nA-5m8tA:
20.25
4d1nB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_C_H4BC760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4d1nC-5m8tA:
undetectable
4d1nD-5m8tA:
undetectable		 4d1nC-5m8tA:
20.25
4d1nD-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_D_H4BD760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4d1nC-5m8tA:
undetectable
4d1nD-5m8tA:
undetectable		 4d1nC-5m8tA:
20.25
4d1nD-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_A_H4BA1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 4d1oA-5m8tA:
undetectable
4d1oB-5m8tA:
undetectable		 4d1oA-5m8tA:
22.16
4d1oB-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_B_H4BB1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 4d1oA-5m8tA:
undetectable
4d1oB-5m8tA:
undetectable		 4d1oA-5m8tA:
22.16
4d1oB-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1P_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 4d1pA-5m8tA:
0.0
4d1pB-5m8tA:
0.0		 4d1pA-5m8tA:
22.16
4d1pB-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 4d1pA-5m8tA:
undetectable
4d1pB-5m8tA:
0.4		 4d1pA-5m8tA:
22.16
4d1pB-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4d2yA-5m8tA:
undetectable
4d2yB-5m8tA:
undetectable		 4d2yA-5m8tA:
20.00
4d2yB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 4d2yA-5m8tA:
undetectable
4d2yB-5m8tA:
undetectable		 4d2yA-5m8tA:
20.00
4d2yB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4d2zA-5m8tA:
undetectable
4d2zB-5m8tA:
undetectable		 4d2zA-5m8tA:
20.00
4d2zB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 4d2zA-5m8tA:
undetectable
4d2zB-5m8tA:
undetectable		 4d2zA-5m8tA:
20.00
4d2zB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D30_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 4d30A-5m8tA:
undetectable
4d30B-5m8tA:
undetectable		 4d30A-5m8tA:
20.00
4d30B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D30_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4d30A-5m8tA:
undetectable
4d30B-5m8tA:
undetectable		 4d30A-5m8tA:
20.00
4d30B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D31_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 4d31A-5m8tA:
undetectable
4d31B-5m8tA:
undetectable		 4d31A-5m8tA:
20.00
4d31B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D31_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4d31A-5m8tA:
undetectable
4d31B-5m8tA:
undetectable		 4d31A-5m8tA:
20.00
4d31B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 4d32A-5m8tA:
undetectable
4d32B-5m8tA:
undetectable		 4d32A-5m8tA:
20.00
4d32B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 4d32A-5m8tA:
undetectable
4d32B-5m8tA:
undetectable		 4d32A-5m8tA:
20.00
4d32B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4d33A-5m8tA:
undetectable
4d33B-5m8tA:
undetectable		 4d33A-5m8tA:
21.75
4d33B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 4d33A-5m8tA:
undetectable
4d33B-5m8tA:
undetectable		 4d33A-5m8tA:
21.75
4d33B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4d34A-5m8tA:
0.0
4d34B-5m8tA:
0.0		 4d34A-5m8tA:
21.75
4d34B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4d34A-5m8tA:
0.0
4d34B-5m8tA:
0.0		 4d34A-5m8tA:
21.75
4d34B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4d35A-5m8tA:
undetectable
4d35B-5m8tA:
0.0		 4d35A-5m8tA:
21.75
4d35B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 4d35A-5m8tA:
undetectable
4d35B-5m8tA:
0.0		 4d35A-5m8tA:
21.75
4d35B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4d36A-5m8tA:
0.3
4d36B-5m8tA:
undetectable		 4d36A-5m8tA:
21.75
4d36B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 4d36A-5m8tA:
0.3
4d36B-5m8tA:
undetectable		 4d36A-5m8tA:
21.75
4d36B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4d37A-5m8tA:
undetectable
4d37B-5m8tA:
0.0		 4d37A-5m8tA:
21.75
4d37B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 4d37A-5m8tA:
undetectable
4d37B-5m8tA:
0.0		 4d37A-5m8tA:
21.75
4d37B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 4d38A-5m8tA:
0.0
4d38B-5m8tA:
undetectable		 4d38A-5m8tA:
21.75
4d38B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.01A 4d38A-5m8tA:
0.0
4d38B-5m8tA:
undetectable		 4d38A-5m8tA:
21.75
4d38B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4d39A-5m8tA:
0.3
4d39B-5m8tA:
undetectable		 4d39A-5m8tA:
21.75
4d39B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4d39A-5m8tA:
0.3
4d39B-5m8tA:
undetectable		 4d39A-5m8tA:
21.75
4d39B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4d3aA-5m8tA:
undetectable
4d3aB-5m8tA:
undetectable		 4d3aA-5m8tA:
21.75
4d3aB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 4d3aA-5m8tA:
undetectable
4d3aB-5m8tA:
undetectable		 4d3aA-5m8tA:
21.75
4d3aB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3B_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4d3bA-5m8tA:
undetectable
4d3bB-5m8tA:
undetectable		 4d3bA-5m8tA:
20.00
4d3bB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3B_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4d3bA-5m8tA:
undetectable
4d3bB-5m8tA:
undetectable		 4d3bA-5m8tA:
20.00
4d3bB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7O_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4d7oA-5m8tA:
undetectable
4d7oB-5m8tA:
undetectable		 4d7oA-5m8tA:
20.00
4d7oB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4d7oA-5m8tA:
undetectable
4d7oB-5m8tA:
undetectable		 4d7oA-5m8tA:
20.00
4d7oB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4euxA-5m8tA:
undetectable
4euxB-5m8tA:
undetectable		 4euxA-5m8tA:
20.00
4euxB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4euxA-5m8tA:
undetectable
4euxB-5m8tA:
undetectable		 4euxA-5m8tA:
20.00
4euxB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4fvwA-5m8tA:
undetectable
4fvwB-5m8tA:
undetectable		 4fvwA-5m8tA:
20.00
4fvwB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4fvwA-5m8tA:
undetectable
4fvwB-5m8tA:
undetectable		 4fvwA-5m8tA:
20.00
4fvwB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4fvxA-5m8tA:
undetectable
4fvxB-5m8tA:
undetectable		 4fvxA-5m8tA:
20.00
4fvxB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4fvxA-5m8tA:
undetectable
4fvxB-5m8tA:
undetectable		 4fvxA-5m8tA:
20.00
4fvxB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4fvyA-5m8tA:
undetectable
4fvyB-5m8tA:
undetectable		 4fvyA-5m8tA:
20.00
4fvyB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4fvyA-5m8tA:
undetectable
4fvyB-5m8tA:
undetectable		 4fvyA-5m8tA:
20.00
4fvyB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4fvzA-5m8tA:
undetectable
4fvzB-5m8tA:
undetectable		 4fvzA-5m8tA:
20.00
4fvzB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4fvzA-5m8tA:
undetectable
4fvzB-5m8tA:
undetectable		 4fvzA-5m8tA:
20.00
4fvzB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FW0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4fw0A-5m8tA:
undetectable
4fw0B-5m8tA:
undetectable		 4fw0A-5m8tA:
20.00
4fw0B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FW0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4fw0A-5m8tA:
undetectable
4fw0B-5m8tA:
undetectable		 4fw0A-5m8tA:
20.00
4fw0B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQE_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4gqeA-5m8tA:
undetectable
4gqeB-5m8tA:
undetectable		 4gqeA-5m8tA:
20.00
4gqeB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4gqeA-5m8tA:
undetectable
4gqeB-5m8tA:
undetectable		 4gqeA-5m8tA:
20.00
4gqeB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 4imtA-5m8tA:
0.0
4imtB-5m8tA:
undetectable		 4imtA-5m8tA:
20.00
4imtB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4imtA-5m8tA:
0.0
4imtB-5m8tA:
undetectable		 4imtA-5m8tA:
20.00
4imtB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.01A 4imwA-5m8tA:
undetectable
4imwB-5m8tA:
0.3		 4imwA-5m8tA:
20.00
4imwB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMW_A_H4BA805_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4imwA-5m8tA:
undetectable
4imwB-5m8tA:
0.3		 4imwA-5m8tA:
20.00
4imwB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_A_H4BA502_1
(SUBUNIT A)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 4imxA-5m8tA:
undetectable
4imxB-5m8tA:
undetectable		 4imxA-5m8tA:
21.65
4imxB-5m8tA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_B_H4BB502_1
(SUBUNIT A)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4imxA-5m8tA:
undetectable
4imxB-5m8tA:
undetectable		 4imxA-5m8tA:
21.65
4imxB-5m8tA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4jsfA-5m8tA:
undetectable
4jsfB-5m8tA:
undetectable		 4jsfA-5m8tA:
20.00
4jsfB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4jsfA-5m8tA:
undetectable
4jsfB-5m8tA:
undetectable		 4jsfA-5m8tA:
20.00
4jsfB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4jsgA-5m8tA:
undetectable
4jsgB-5m8tA:
undetectable		 4jsgA-5m8tA:
20.00
4jsgB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4jsgA-5m8tA:
undetectable
4jsgB-5m8tA:
undetectable		 4jsgA-5m8tA:
20.00
4jsgB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSH_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4jshA-5m8tA:
undetectable
4jshB-5m8tA:
undetectable		 4jshA-5m8tA:
20.00
4jshB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSH_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 4jshA-5m8tA:
undetectable
4jshB-5m8tA:
undetectable		 4jshA-5m8tA:
20.00
4jshB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4jsiA-5m8tA:
undetectable
4jsiB-5m8tA:
undetectable		 4jsiA-5m8tA:
20.00
4jsiB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 4jsiA-5m8tA:
undetectable
4jsiB-5m8tA:
undetectable		 4jsiA-5m8tA:
20.00
4jsiB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4jsjA-5m8tA:
undetectable
4jsjB-5m8tA:
undetectable		 4jsjA-5m8tA:
20.00
4jsjB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4jsjA-5m8tA:
undetectable
4jsjB-5m8tA:
undetectable		 4jsjA-5m8tA:
20.00
4jsjB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSK_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 4jskA-5m8tA:
0.0
4jskB-5m8tA:
0.0		 4jskA-5m8tA:
21.75
4jskB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSK_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 4jskA-5m8tA:
undetectable
4jskB-5m8tA:
0.4		 4jskA-5m8tA:
21.75
4jskB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSL_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4jslA-5m8tA:
undetectable
4jslB-5m8tA:
0.5		 4jslA-5m8tA:
21.75
4jslB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSL_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 4jslA-5m8tA:
undetectable
4jslB-5m8tA:
0.5		 4jslA-5m8tA:
21.75
4jslB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4jsmA-5m8tA:
undetectable
4jsmB-5m8tA:
undetectable		 4jsmA-5m8tA:
21.75
4jsmB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.02A 4jsmA-5m8tA:
undetectable
4jsmB-5m8tA:
undetectable		 4jsmA-5m8tA:
21.75
4jsmB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5D_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4k5dA-5m8tA:
undetectable
4k5dB-5m8tA:
undetectable		 4k5dA-5m8tA:
20.00
4k5dB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5D_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.11A 4k5dA-5m8tA:
undetectable
4k5dB-5m8tA:
undetectable		 4k5dA-5m8tA:
20.00
4k5dB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5E_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4k5eA-5m8tA:
undetectable
4k5eB-5m8tA:
undetectable		 4k5eA-5m8tA:
20.00
4k5eB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5E_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4k5eA-5m8tA:
undetectable
4k5eB-5m8tA:
undetectable		 4k5eA-5m8tA:
20.00
4k5eB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4k5fA-5m8tA:
undetectable
4k5fB-5m8tA:
undetectable		 4k5fA-5m8tA:
20.00
4k5fB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4k5fA-5m8tA:
undetectable
4k5fB-5m8tA:
undetectable		 4k5fA-5m8tA:
20.00
4k5fB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4k5gA-5m8tA:
undetectable
4k5gB-5m8tA:
undetectable		 4k5gA-5m8tA:
20.00
4k5gB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4k5gA-5m8tA:
undetectable
4k5gB-5m8tA:
undetectable		 4k5gA-5m8tA:
20.00
4k5gB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 4k5hA-5m8tA:
undetectable
4k5hB-5m8tA:
0.0		 4k5hA-5m8tA:
21.75
4k5hB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4k5hA-5m8tA:
undetectable
4k5hB-5m8tA:
0.0		 4k5hA-5m8tA:
21.75
4k5hB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4k5iA-5m8tA:
undetectable
4k5iB-5m8tA:
undetectable		 4k5iA-5m8tA:
21.75
4k5iB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4k5iA-5m8tA:
undetectable
4k5iB-5m8tA:
undetectable		 4k5iA-5m8tA:
21.75
4k5iB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 4k5jA-5m8tA:
0.0
4k5jB-5m8tA:
undetectable		 4k5jA-5m8tA:
21.75
4k5jB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4k5jA-5m8tA:
undetectable
4k5jB-5m8tA:
undetectable		 4k5jA-5m8tA:
21.75
4k5jB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4k5kA-5m8tA:
0.3
4k5kB-5m8tA:
undetectable		 4k5kA-5m8tA:
21.75
4k5kB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 4k5kA-5m8tA:
0.3
4k5kB-5m8tA:
undetectable		 4k5kA-5m8tA:
21.75
4k5kB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCH_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4kchA-5m8tA:
undetectable
4kchB-5m8tA:
undetectable		 4kchA-5m8tA:
20.00
4kchB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCH_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4kchA-5m8tA:
undetectable
4kchB-5m8tA:
undetectable		 4kchA-5m8tA:
20.00
4kchB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4kciA-5m8tA:
undetectable
4kciB-5m8tA:
undetectable		 4kciA-5m8tA:
20.00
4kciB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 4kciA-5m8tA:
undetectable
4kciB-5m8tA:
undetectable		 4kciA-5m8tA:
20.00
4kciB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4kcjA-5m8tA:
undetectable
4kcjB-5m8tA:
undetectable		 4kcjA-5m8tA:
20.00
4kcjB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4kcjA-5m8tA:
undetectable
4kcjB-5m8tA:
undetectable		 4kcjA-5m8tA:
20.00
4kcjB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.11A 4kckA-5m8tA:
undetectable
4kckB-5m8tA:
undetectable		 4kckA-5m8tA:
20.00
4kckB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4kckA-5m8tA:
undetectable
4kckB-5m8tA:
undetectable		 4kckA-5m8tA:
20.00
4kckB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCL_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4kclA-5m8tA:
undetectable
4kclB-5m8tA:
0.3		 4kclA-5m8tA:
20.00
4kclB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 4kclA-5m8tA:
undetectable
4kclB-5m8tA:
undetectable		 4kclA-5m8tA:
20.00
4kclB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCM_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.11A 4kcmA-5m8tA:
undetectable
4kcmB-5m8tA:
undetectable		 4kcmA-5m8tA:
20.00
4kcmB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCM_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4kcmA-5m8tA:
undetectable
4kcmB-5m8tA:
undetectable		 4kcmA-5m8tA:
20.00
4kcmB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4kcnA-5m8tA:
undetectable
4kcnB-5m8tA:
0.0		 4kcnA-5m8tA:
20.00
4kcnB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 4kcnA-5m8tA:
undetectable
4kcnB-5m8tA:
undetectable		 4kcnA-5m8tA:
20.00
4kcnB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4kcoA-5m8tA:
undetectable
4kcoB-5m8tA:
undetectable		 4kcoA-5m8tA:
20.00
4kcoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4kcoA-5m8tA:
undetectable
4kcoB-5m8tA:
undetectable		 4kcoA-5m8tA:
20.00
4kcoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4kcpA-5m8tA:
undetectable
4kcpB-5m8tA:
0.5		 4kcpA-5m8tA:
21.75
4kcpB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4kcpA-5m8tA:
undetectable
4kcpB-5m8tA:
0.5		 4kcpA-5m8tA:
21.75
4kcpB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4kcqA-5m8tA:
0.5
4kcqB-5m8tA:
undetectable		 4kcqA-5m8tA:
21.75
4kcqB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 4kcqA-5m8tA:
0.5
4kcqB-5m8tA:
undetectable		 4kcqA-5m8tA:
21.75
4kcqB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4kcrA-5m8tA:
0.4
4kcrB-5m8tA:
undetectable		 4kcrA-5m8tA:
21.75
4kcrB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4kcrA-5m8tA:
0.4
4kcrB-5m8tA:
undetectable		 4kcrA-5m8tA:
21.75
4kcrB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4kcsA-5m8tA:
0.4
4kcsB-5m8tA:
undetectable		 4kcsA-5m8tA:
21.75
4kcsB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4kcsA-5m8tA:
0.4
4kcsB-5m8tA:
undetectable		 4kcsA-5m8tA:
21.75
4kcsB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4luwA-5m8tA:
undetectable
4luwB-5m8tA:
undetectable		 4luwA-5m8tA:
21.75
4luwB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4luwA-5m8tA:
undetectable
4luwB-5m8tA:
undetectable		 4luwA-5m8tA:
21.75
4luwB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4luxA-5m8tA:
undetectable
4luxB-5m8tA:
undetectable		 4luxA-5m8tA:
20.00
4luxB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 4luxA-5m8tA:
undetectable
4luxB-5m8tA:
undetectable		 4luxA-5m8tA:
20.00
4luxB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.02A 4nosA-5m8tA:
0.0
4nosB-5m8tA:
undetectable		 4nosA-5m8tA:
20.73
4nosB-5m8tA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.02A 4nosC-5m8tA:
undetectable
4nosD-5m8tA:
undetectable		 4nosC-5m8tA:
20.73
4nosD-5m8tA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4nosC-5m8tA:
undetectable
4nosD-5m8tA:
undetectable		 4nosC-5m8tA:
20.73
4nosD-5m8tA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 7 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
 0.36A 4p6sA-5m8tA:
32.6		 4p6sA-5m8tA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 7 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
 0.42A 4p6sB-5m8tA:
32.4		 4p6sB-5m8tA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 GLU A 307
THR A 191
HIS A 227
LEU A 231
 None
 1.07A 4pfjA-5m8tA:
undetectable		 4pfjA-5m8tA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 4uchA-5m8tA:
undetectable
4uchB-5m8tA:
undetectable		 4uchA-5m8tA:
20.16
4uchB-5m8tA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.12A 4uchA-5m8tA:
undetectable
4uchB-5m8tA:
undetectable		 4uchA-5m8tA:
20.16
4uchB-5m8tA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4ugzA-5m8tA:
undetectable
4ugzB-5m8tA:
undetectable		 4ugzA-5m8tA:
20.00
4ugzB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4ugzA-5m8tA:
undetectable
4ugzB-5m8tA:
undetectable		 4ugzA-5m8tA:
20.00
4ugzB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4uh0A-5m8tA:
undetectable
4uh0B-5m8tA:
0.0		 4uh0A-5m8tA:
20.00
4uh0B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4uh0A-5m8tA:
undetectable
4uh0B-5m8tA:
0.0		 4uh0A-5m8tA:
20.00
4uh0B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.02A 4uh1A-5m8tA:
undetectable
4uh1B-5m8tA:
undetectable		 4uh1A-5m8tA:
20.00
4uh1B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4uh1A-5m8tA:
undetectable
4uh1B-5m8tA:
undetectable		 4uh1A-5m8tA:
20.00
4uh1B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4uh2A-5m8tA:
undetectable
4uh2B-5m8tA:
undetectable		 4uh2A-5m8tA:
20.00
4uh2B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4uh2A-5m8tA:
undetectable
4uh2B-5m8tA:
undetectable		 4uh2A-5m8tA:
20.00
4uh2B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 4uh3A-5m8tA:
undetectable
4uh3B-5m8tA:
0.0		 4uh3A-5m8tA:
20.00
4uh3B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4uh3A-5m8tA:
undetectable
4uh3B-5m8tA:
undetectable		 4uh3A-5m8tA:
20.00
4uh3B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4uh4A-5m8tA:
undetectable
4uh4B-5m8tA:
undetectable		 4uh4A-5m8tA:
20.00
4uh4B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.12A 4uh4A-5m8tA:
undetectable
4uh4B-5m8tA:
undetectable		 4uh4A-5m8tA:
20.00
4uh4B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 4uh5A-5m8tA:
undetectable
4uh5B-5m8tA:
undetectable		 4uh5A-5m8tA:
20.25
4uh5B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4uh5A-5m8tA:
undetectable
4uh5B-5m8tA:
undetectable		 4uh5A-5m8tA:
20.25
4uh5B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4uh6A-5m8tA:
undetectable
4uh6B-5m8tA:
undetectable		 4uh6A-5m8tA:
20.25
4uh6B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4uh6A-5m8tA:
undetectable
4uh6B-5m8tA:
undetectable		 4uh6A-5m8tA:
20.25
4uh6B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 4uh7A-5m8tA:
0.0
4uh7B-5m8tA:
undetectable		 4uh7A-5m8tA:
21.75
4uh7B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 4uh7A-5m8tA:
0.0
4uh7B-5m8tA:
undetectable		 4uh7A-5m8tA:
21.75
4uh7B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4uh8A-5m8tA:
undetectable
4uh8B-5m8tA:
undetectable		 4uh8A-5m8tA:
21.75
4uh8B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 4uh8A-5m8tA:
undetectable
4uh8B-5m8tA:
undetectable		 4uh8A-5m8tA:
21.75
4uh8B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4uh9A-5m8tA:
0.5
4uh9B-5m8tA:
0.0		 4uh9A-5m8tA:
21.75
4uh9B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4uh9A-5m8tA:
0.5
4uh9B-5m8tA:
0.0		 4uh9A-5m8tA:
21.75
4uh9B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 4uhaA-5m8tA:
undetectable
4uhaB-5m8tA:
undetectable		 4uhaA-5m8tA:
21.75
4uhaB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4uhaA-5m8tA:
undetectable
4uhaB-5m8tA:
undetectable		 4uhaA-5m8tA:
21.75
4uhaB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPM_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4upmA-5m8tA:
undetectable
4upmB-5m8tA:
undetectable		 4upmA-5m8tA:
20.00
4upmB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPM_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4upmA-5m8tA:
undetectable
4upmB-5m8tA:
undetectable		 4upmA-5m8tA:
20.00
4upmB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPN_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4upnA-5m8tA:
undetectable
4upnB-5m8tA:
undetectable		 4upnA-5m8tA:
20.00
4upnB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPN_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4upnA-5m8tA:
undetectable
4upnB-5m8tA:
undetectable		 4upnA-5m8tA:
20.00
4upnB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4upoA-5m8tA:
undetectable
4upoB-5m8tA:
undetectable		 4upoA-5m8tA:
20.00
4upoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 4upoA-5m8tA:
undetectable
4upoB-5m8tA:
undetectable		 4upoA-5m8tA:
20.00
4upoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4uppA-5m8tA:
undetectable
4uppB-5m8tA:
undetectable		 4uppA-5m8tA:
20.00
4uppB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4uppA-5m8tA:
undetectable
4uppB-5m8tA:
undetectable		 4uppA-5m8tA:
20.00
4uppB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4upqA-5m8tA:
undetectable
4upqB-5m8tA:
undetectable		 4upqA-5m8tA:
21.75
4upqB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4upqA-5m8tA:
undetectable
4upqB-5m8tA:
undetectable		 4upqA-5m8tA:
21.75
4upqB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4uprA-5m8tA:
undetectable
4uprB-5m8tA:
0.5		 4uprA-5m8tA:
21.75
4uprB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 4uprA-5m8tA:
undetectable
4uprB-5m8tA:
0.5		 4uprA-5m8tA:
21.75
4uprB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPS_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 4upsA-5m8tA:
undetectable
4upsB-5m8tA:
0.6		 4upsA-5m8tA:
21.75
4upsB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPS_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 4upsA-5m8tA:
undetectable
4upsB-5m8tA:
0.6		 4upsA-5m8tA:
21.75
4upsB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 4uptA-5m8tA:
undetectable
4uptB-5m8tA:
0.0		 4uptA-5m8tA:
21.75
4uptB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 4uptA-5m8tA:
undetectable
4uptB-5m8tA:
0.0		 4uptA-5m8tA:
21.75
4uptB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4v3uA-5m8tA:
undetectable
4v3uB-5m8tA:
undetectable		 4v3uA-5m8tA:
20.25
4v3uB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4v3uA-5m8tA:
undetectable
4v3uB-5m8tA:
undetectable		 4v3uA-5m8tA:
20.25
4v3uB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_C_H4BC760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 4v3uC-5m8tA:
undetectable
4v3uD-5m8tA:
undetectable		 4v3uC-5m8tA:
20.25
4v3uD-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_D_H4BD760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4v3uC-5m8tA:
undetectable
4v3uD-5m8tA:
undetectable		 4v3uC-5m8tA:
20.25
4v3uD-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3V_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 4v3vA-5m8tA:
0.0
4v3vB-5m8tA:
undetectable		 4v3vA-5m8tA:
20.00
4v3vB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3V_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4v3vA-5m8tA:
0.0
4v3vB-5m8tA:
undetectable		 4v3vA-5m8tA:
20.00
4v3vB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 4v3wA-5m8tA:
undetectable
4v3wB-5m8tA:
undetectable		 4v3wA-5m8tA:
20.00
4v3wB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3X_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 4v3xA-5m8tA:
undetectable
4v3xB-5m8tA:
undetectable		 4v3xA-5m8tA:
20.00
4v3xB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3X_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 4v3xA-5m8tA:
undetectable
4v3xB-5m8tA:
undetectable		 4v3xA-5m8tA:
20.00
4v3xB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 4v3yA-5m8tA:
undetectable
4v3yB-5m8tA:
undetectable		 4v3yA-5m8tA:
20.00
4v3yB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 4v3yA-5m8tA:
undetectable
4v3yB-5m8tA:
undetectable		 4v3yA-5m8tA:
20.00
4v3yB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 4v3zA-5m8tA:
undetectable
4v3zB-5m8tA:
undetectable		 4v3zA-5m8tA:
20.00
4v3zB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 4v3zA-5m8tA:
undetectable
4v3zB-5m8tA:
undetectable		 4v3zA-5m8tA:
20.00
4v3zB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 HIS A 215
GLY A 217
GLU A 360
ARG A 356
 ZN  A 512 ( 3.3A)
None
None
None
 1.04A 4zbqA-5m8tA:
undetectable		 4zbqA-5m8tA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A  28
ARG A 230
ASP A 234
ILE A 184
 FUC  A 505 ( 4.3A)
None
None
None
 1.13A 5a06B-5m8tA:
undetectable		 5a06B-5m8tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 5ad4A-5m8tA:
undetectable
5ad4B-5m8tA:
undetectable		 5ad4A-5m8tA:
20.00
5ad4B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 5ad4A-5m8tA:
undetectable
5ad4B-5m8tA:
undetectable		 5ad4A-5m8tA:
20.00
5ad4B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 5ad5A-5m8tA:
undetectable
5ad5B-5m8tA:
undetectable		 5ad5A-5m8tA:
20.00
5ad5B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5ad5A-5m8tA:
undetectable
5ad5B-5m8tA:
undetectable		 5ad5A-5m8tA:
20.00
5ad5B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 5ad6A-5m8tA:
0.0
5ad6B-5m8tA:
undetectable		 5ad6A-5m8tA:
20.00
5ad6B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5ad6A-5m8tA:
undetectable
5ad6B-5m8tA:
undetectable		 5ad6A-5m8tA:
20.00
5ad6B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD7_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5ad7A-5m8tA:
undetectable
5ad7B-5m8tA:
undetectable		 5ad7A-5m8tA:
20.00
5ad7B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5ad8A-5m8tA:
undetectable
5ad8B-5m8tA:
undetectable		 5ad8A-5m8tA:
20.00
5ad8B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 5ad9A-5m8tA:
undetectable
5ad9B-5m8tA:
undetectable		 5ad9A-5m8tA:
20.00
5ad9B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 5ad9A-5m8tA:
undetectable
5ad9B-5m8tA:
undetectable		 5ad9A-5m8tA:
20.00
5ad9B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5adaA-5m8tA:
undetectable
5adaB-5m8tA:
undetectable		 5adaA-5m8tA:
20.00
5adaB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 5adaA-5m8tA:
undetectable
5adaB-5m8tA:
undetectable		 5adaA-5m8tA:
20.00
5adaB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADB_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 5adbA-5m8tA:
undetectable
5adbB-5m8tA:
undetectable		 5adbA-5m8tA:
20.00
5adbB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADC_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5adcA-5m8tA:
undetectable
5adcB-5m8tA:
undetectable		 5adcA-5m8tA:
20.00
5adcB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADC_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5adcA-5m8tA:
undetectable
5adcB-5m8tA:
undetectable		 5adcA-5m8tA:
20.00
5adcB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5addA-5m8tA:
undetectable
5addB-5m8tA:
undetectable		 5addA-5m8tA:
20.21
5addB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5adeA-5m8tA:
undetectable
5adeB-5m8tA:
undetectable		 5adeA-5m8tA:
20.21
5adeB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 5adfA-5m8tA:
undetectable
5adfB-5m8tA:
undetectable		 5adfA-5m8tA:
20.25
5adfB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 5adgA-5m8tA:
undetectable
5adgB-5m8tA:
undetectable		 5adgA-5m8tA:
20.25
5adgB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5adgA-5m8tA:
undetectable
5adgB-5m8tA:
undetectable		 5adgA-5m8tA:
20.25
5adgB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADI_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5adiA-5m8tA:
undetectable
5adiB-5m8tA:
undetectable		 5adiA-5m8tA:
20.25
5adiB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5adjA-5m8tA:
undetectable
5adjB-5m8tA:
undetectable		 5adjA-5m8tA:
21.75
5adjB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 5adjA-5m8tA:
undetectable
5adjB-5m8tA:
undetectable		 5adjA-5m8tA:
21.75
5adjB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5adkA-5m8tA:
0.0
5adkB-5m8tA:
undetectable		 5adkA-5m8tA:
21.75
5adkB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 5adkA-5m8tA:
0.0
5adkB-5m8tA:
undetectable		 5adkA-5m8tA:
21.75
5adkB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 5adlA-5m8tA:
undetectable
5adlB-5m8tA:
0.1		 5adlA-5m8tA:
21.75
5adlB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 5adlA-5m8tA:
undetectable
5adlB-5m8tA:
undetectable		 5adlA-5m8tA:
21.75
5adlB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 5admA-5m8tA:
undetectable
5admB-5m8tA:
0.5		 5admA-5m8tA:
21.75
5admB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5admA-5m8tA:
undetectable
5admB-5m8tA:
0.5		 5admA-5m8tA:
21.75
5admB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 5adnA-5m8tA:
0.0
5adnB-5m8tA:
undetectable		 5adnA-5m8tA:
21.75
5adnB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 5adnA-5m8tA:
0.0
5adnB-5m8tA:
undetectable		 5adnA-5m8tA:
21.75
5adnB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGK_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 5agkA-5m8tA:
undetectable
5agkB-5m8tA:
undetectable		 5agkA-5m8tA:
20.00
5agkB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5agkA-5m8tA:
undetectable
5agkB-5m8tA:
undetectable		 5agkA-5m8tA:
20.00
5agkB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 5aglA-5m8tA:
undetectable
5aglB-5m8tA:
undetectable		 5aglA-5m8tA:
20.00
5aglB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 5aglA-5m8tA:
undetectable
5aglB-5m8tA:
undetectable		 5aglA-5m8tA:
20.00
5aglB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5agmA-5m8tA:
undetectable
5agmB-5m8tA:
undetectable		 5agmA-5m8tA:
20.00
5agmB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 5agmA-5m8tA:
undetectable
5agmB-5m8tA:
undetectable		 5agmA-5m8tA:
20.00
5agmB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 5agnA-5m8tA:
undetectable
5agnB-5m8tA:
undetectable		 5agnA-5m8tA:
20.00
5agnB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5agnA-5m8tA:
undetectable
5agnB-5m8tA:
undetectable		 5agnA-5m8tA:
20.00
5agnB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 5agoA-5m8tA:
undetectable
5agoB-5m8tA:
undetectable		 5agoA-5m8tA:
20.00
5agoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5agoA-5m8tA:
undetectable
5agoB-5m8tA:
undetectable		 5agoA-5m8tA:
20.00
5agoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5agpA-5m8tA:
undetectable
5agpB-5m8tA:
undetectable		 5agpA-5m8tA:
20.00
5agpB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5agpA-5m8tA:
undetectable
5agpB-5m8tA:
undetectable		 5agpA-5m8tA:
20.00
5agpB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		3 / 3 TYR A 296
THR A 298
THR A 301
 NAG  A 506 ( 4.9A)
None
None
 0.67A 5aoxB-5m8tA:
undetectable		 5aoxB-5m8tA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		3 / 3 TYR A 296
THR A 298
THR A 301
 NAG  A 506 ( 4.9A)
None
None
 0.74A 5aoxE-5m8tA:
undetectable		 5aoxE-5m8tA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 5fj2A-5m8tA:
0.0
5fj2B-5m8tA:
undetectable		 5fj2A-5m8tA:
21.75
5fj2B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5fj2A-5m8tA:
0.0
5fj2B-5m8tA:
undetectable		 5fj2A-5m8tA:
21.75
5fj2B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5fj3A-5m8tA:
undetectable
5fj3B-5m8tA:
0.0		 5fj3A-5m8tA:
21.75
5fj3B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5fj3A-5m8tA:
undetectable
5fj3B-5m8tA:
undetectable		 5fj3A-5m8tA:
21.75
5fj3B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 5fvpA-5m8tA:
undetectable
5fvpB-5m8tA:
undetectable		 5fvpA-5m8tA:
20.00
5fvpB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5fvpA-5m8tA:
undetectable
5fvpB-5m8tA:
undetectable		 5fvpA-5m8tA:
20.00
5fvpB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5fvqA-5m8tA:
undetectable
5fvqB-5m8tA:
undetectable		 5fvqA-5m8tA:
20.00
5fvqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5fvqA-5m8tA:
undetectable
5fvqB-5m8tA:
undetectable		 5fvqA-5m8tA:
20.00
5fvqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 5fvrA-5m8tA:
undetectable
5fvrB-5m8tA:
undetectable		 5fvrA-5m8tA:
20.00
5fvrB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5fvrA-5m8tA:
undetectable
5fvrB-5m8tA:
undetectable		 5fvrA-5m8tA:
20.00
5fvrB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 5fvsA-5m8tA:
undetectable
5fvsB-5m8tA:
undetectable		 5fvsA-5m8tA:
20.00
5fvsB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5fvsA-5m8tA:
undetectable
5fvsB-5m8tA:
undetectable		 5fvsA-5m8tA:
20.00
5fvsB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5fvtA-5m8tA:
undetectable
5fvtB-5m8tA:
undetectable		 5fvtA-5m8tA:
20.00
5fvtB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5fvtA-5m8tA:
undetectable
5fvtB-5m8tA:
undetectable		 5fvtA-5m8tA:
20.00
5fvtB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 5fvuA-5m8tA:
undetectable
5fvuB-5m8tA:
undetectable		 5fvuA-5m8tA:
20.25
5fvuB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 5fvuA-5m8tA:
undetectable
5fvuB-5m8tA:
undetectable		 5fvuA-5m8tA:
20.25
5fvuB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5fvvA-5m8tA:
0.0
5fvvB-5m8tA:
undetectable		 5fvvA-5m8tA:
20.25
5fvvB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5fvvA-5m8tA:
0.0
5fvvB-5m8tA:
undetectable		 5fvvA-5m8tA:
20.25
5fvvB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 5fvwA-5m8tA:
undetectable
5fvwB-5m8tA:
undetectable		 5fvwA-5m8tA:
20.25
5fvwB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.01A 5fvwA-5m8tA:
undetectable
5fvwB-5m8tA:
undetectable		 5fvwA-5m8tA:
20.25
5fvwB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5fvxA-5m8tA:
undetectable
5fvxB-5m8tA:
undetectable		 5fvxA-5m8tA:
20.25
5fvxB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5fvyA-5m8tA:
undetectable
5fvyB-5m8tA:
undetectable		 5fvyA-5m8tA:
21.75
5fvyB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 5fvyA-5m8tA:
undetectable
5fvyB-5m8tA:
undetectable		 5fvyA-5m8tA:
21.75
5fvyB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5fvzA-5m8tA:
undetectable
5fvzB-5m8tA:
0.4		 5fvzA-5m8tA:
21.75
5fvzB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5fvzA-5m8tA:
undetectable
5fvzB-5m8tA:
0.4		 5fvzA-5m8tA:
21.75
5fvzB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 5fw0A-5m8tA:
undetectable
5fw0B-5m8tA:
undetectable		 5fw0A-5m8tA:
20.00
5fw0B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 5fw0A-5m8tA:
undetectable
5fw0B-5m8tA:
undetectable		 5fw0A-5m8tA:
20.00
5fw0B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5g0nA-5m8tA:
undetectable
5g0nB-5m8tA:
undetectable		 5g0nA-5m8tA:
20.21
5g0nB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5g0nA-5m8tA:
undetectable
5g0nB-5m8tA:
undetectable		 5g0nA-5m8tA:
20.21
5g0nB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 5g0oA-5m8tA:
undetectable
5g0oB-5m8tA:
undetectable		 5g0oA-5m8tA:
20.21
5g0oB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 5g0oA-5m8tA:
undetectable
5g0oB-5m8tA:
undetectable		 5g0oA-5m8tA:
20.21
5g0oB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5g0pA-5m8tA:
undetectable
5g0pB-5m8tA:
undetectable		 5g0pA-5m8tA:
20.21
5g0pB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5g0pA-5m8tA:
undetectable
5g0pB-5m8tA:
undetectable		 5g0pA-5m8tA:
20.21
5g0pB-5m8tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 7 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
 0.27A 5i3aA-5m8tA:
32.6		 5i3aA-5m8tA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 7 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
 0.33A 5i3aB-5m8tA:
32.6		 5i3aB-5m8tA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 7 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
 0.36A 5i3bA-5m8tA:
32.6		 5i3bA-5m8tA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 HIS A 192
HIS A 215
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
 0.39A 5i3bB-5m8tA:
32.7		 5i3bB-5m8tA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 PRO A  77
HIS A 434
TYR A 369
PHE A 362
 None
 1.17A 5igjA-5m8tA:
undetectable		 5igjA-5m8tA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 LEU A 337
PHE A 406
LEU A 376
TRP A 468
 None
 1.17A 5m10A-5m8tA:
undetectable		 5m10A-5m8tA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		7 / 10 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.2A)
 0.14A 5m8nA-5m8tA:
68.1		 5m8nA-5m8tA:
99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 10 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.37A 5m8nA-5m8tA:
68.1		 5m8nA-5m8tA:
99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		7 / 10 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.2A)
 0.13A 5m8nB-5m8tA:
67.8		 5m8nB-5m8tA:
99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 10 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.40A 5m8nB-5m8tA:
67.8		 5m8nB-5m8tA:
99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 9 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.19A 5m8nC-5m8tA:
67.4		 5m8nC-5m8tA:
99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 9 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.35A 5m8nC-5m8tA:
67.4		 5m8nC-5m8tA:
99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_D_MMSD515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 9 HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.2A)
 0.30A 5m8nD-5m8tA:
67.2		 5m8nD-5m8tA:
99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		7 / 7 HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
 0.25A 5m8rA-5m8tA:
69.1		 5m8rA-5m8tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		8 / 8 HIS A 215
SER A 374
HIS A 377
ASN A 378
HIS A 381
LEU A 382
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
None
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
 0.42A 5m8rB-5m8tA:
68.2		 5m8rB-5m8tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 HIS A 381
HIS A 215
HIS A 224
LEU A 221
 ZN  A 511 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
None
 0.94A 5m8rB-5m8tA:
68.2		 5m8rB-5m8tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		8 / 8 HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
GLY A 389
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
 0.29A 5m8rC-5m8tA:
68.7		 5m8rC-5m8tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 HIS A 215
HIS A 377
HIS A 381
GLY A 388
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
None
 0.88A 5m8rC-5m8tA:
68.7		 5m8rC-5m8tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		8 / 8 HIS A 215
SER A 374
HIS A 377
ASN A 378
HIS A 381
LEU A 382
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
None
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
 0.37A 5m8rD-5m8tA:
68.4		 5m8rD-5m8tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 HIS A 381
HIS A 215
HIS A 224
LEU A 221
 ZN  A 511 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
None
 0.93A 5m8rD-5m8tA:
68.4		 5m8rD-5m8tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 215
HIS A 224
HIS A 192
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
 0.36A 5migA-5m8tA:
undetectable		 5migA-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 PHE A 383
LEU A 382
ARG A 313
GLY A 388
 None
 0.92A 5o4yF-5m8tA:
undetectable		 5o4yF-5m8tA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 227
HIS A 224
HIS A 404
 None
ZN  A 512 (-3.5A)
ZN  A 511 (-3.1A)
 0.92A 5oexA-5m8tA:
undetectable		 5oexA-5m8tA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5unrA-5m8tA:
undetectable
5unrB-5m8tA:
undetectable		 5unrA-5m8tA:
20.00
5unrB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 5unsA-5m8tA:
undetectable
5unsB-5m8tA:
undetectable		 5unsA-5m8tA:
20.00
5unsB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5unsA-5m8tA:
undetectable
5unsB-5m8tA:
undetectable		 5unsA-5m8tA:
20.00
5unsB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 5untA-5m8tA:
undetectable
5untB-5m8tA:
undetectable		 5untA-5m8tA:
20.00
5untB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5untA-5m8tA:
undetectable
5untB-5m8tA:
undetectable		 5untA-5m8tA:
20.00
5untB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5unuA-5m8tA:
undetectable
5unuB-5m8tA:
undetectable		 5unuA-5m8tA:
20.00
5unuB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5unuA-5m8tA:
undetectable
5unuB-5m8tA:
undetectable		 5unuA-5m8tA:
20.00
5unuB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.11A 5unvA-5m8tA:
undetectable
5unvB-5m8tA:
undetectable		 5unvA-5m8tA:
20.00
5unvB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5unvA-5m8tA:
undetectable
5unvB-5m8tA:
undetectable		 5unvA-5m8tA:
20.00
5unvB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 5unwA-5m8tA:
undetectable
5unwB-5m8tA:
undetectable		 5unwA-5m8tA:
20.00
5unwB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 5unwA-5m8tA:
undetectable
5unwB-5m8tA:
undetectable		 5unwA-5m8tA:
20.00
5unwB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 5unxA-5m8tA:
undetectable
5unxB-5m8tA:
undetectable		 5unxA-5m8tA:
20.00
5unxB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 5unxA-5m8tA:
undetectable
5unxB-5m8tA:
undetectable		 5unxA-5m8tA:
20.00
5unxB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 5unyA-5m8tA:
undetectable
5unyB-5m8tA:
undetectable		 5unyA-5m8tA:
20.00
5unyB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 5unyA-5m8tA:
undetectable
5unyB-5m8tA:
undetectable		 5unyA-5m8tA:
20.00
5unyB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 5unzA-5m8tA:
undetectable
5unzB-5m8tA:
undetectable		 5unzA-5m8tA:
20.00
5unzB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5uo0A-5m8tA:
undetectable
5uo0B-5m8tA:
undetectable		 5uo0A-5m8tA:
20.00
5uo0B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 5uo1A-5m8tA:
undetectable
5uo1B-5m8tA:
undetectable		 5uo1A-5m8tA:
20.25
5uo1B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 5uo1A-5m8tA:
undetectable
5uo1B-5m8tA:
undetectable		 5uo1A-5m8tA:
20.25
5uo1B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 5uo2A-5m8tA:
undetectable
5uo2B-5m8tA:
undetectable		 5uo2A-5m8tA:
20.25
5uo2B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 5uo2A-5m8tA:
undetectable
5uo2B-5m8tA:
undetectable		 5uo2A-5m8tA:
20.25
5uo2B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 5uo3A-5m8tA:
undetectable
5uo3B-5m8tA:
undetectable		 5uo3A-5m8tA:
20.25
5uo3B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5uo3A-5m8tA:
undetectable
5uo3B-5m8tA:
undetectable		 5uo3A-5m8tA:
20.25
5uo3B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 5uo4A-5m8tA:
undetectable
5uo4B-5m8tA:
undetectable		 5uo4A-5m8tA:
20.25
5uo4B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.11A 5uo4A-5m8tA:
undetectable
5uo4B-5m8tA:
undetectable		 5uo4A-5m8tA:
20.25
5uo4B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 5uo5A-5m8tA:
undetectable
5uo5B-5m8tA:
undetectable		 5uo5A-5m8tA:
20.25
5uo5B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5uo5A-5m8tA:
undetectable
5uo5B-5m8tA:
undetectable		 5uo5A-5m8tA:
20.25
5uo5B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5uo6A-5m8tA:
undetectable
5uo6B-5m8tA:
undetectable		 5uo6A-5m8tA:
20.25
5uo6B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 8 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5uo7A-5m8tA:
undetectable
5uo7B-5m8tA:
undetectable		 5uo7A-5m8tA:
20.25
5uo7B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5uo7A-5m8tA:
undetectable
5uo7B-5m8tA:
undetectable		 5uo7A-5m8tA:
20.25
5uo7B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 5uo8A-5m8tA:
undetectable
5uo8B-5m8tA:
undetectable		 5uo8A-5m8tA:
22.16
5uo8B-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 5uo8A-5m8tA:
undetectable
5uo8B-5m8tA:
0.0		 5uo8A-5m8tA:
22.16
5uo8B-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 5uo8C-5m8tA:
0.0
5uo8D-5m8tA:
undetectable		 5uo8C-5m8tA:
22.16
5uo8D-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5uo8C-5m8tA:
0.0
5uo8D-5m8tA:
undetectable		 5uo8C-5m8tA:
22.16
5uo8D-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 5uo9A-5m8tA:
0.0
5uo9B-5m8tA:
0.0		 5uo9A-5m8tA:
22.16
5uo9B-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5uo9A-5m8tA:
0.0
5uo9B-5m8tA:
undetectable		 5uo9A-5m8tA:
22.16
5uo9B-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.00A 5uo9C-5m8tA:
0.0
5uo9D-5m8tA:
undetectable		 5uo9C-5m8tA:
22.16
5uo9D-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 5uo9C-5m8tA:
undetectable
5uo9D-5m8tA:
undetectable		 5uo9C-5m8tA:
22.16
5uo9D-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5uodA-5m8tA:
undetectable
5uodB-5m8tA:
undetectable		 5uodA-5m8tA:
21.75
5uodB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5uodA-5m8tA:
undetectable
5uodB-5m8tA:
undetectable		 5uodA-5m8tA:
21.75
5uodB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5vuiA-5m8tA:
undetectable
5vuiB-5m8tA:
undetectable		 5vuiA-5m8tA:
20.00
5vuiB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5vuiA-5m8tA:
undetectable
5vuiB-5m8tA:
undetectable		 5vuiA-5m8tA:
20.00
5vuiB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5vujA-5m8tA:
undetectable
5vujB-5m8tA:
0.0		 5vujA-5m8tA:
20.00
5vujB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5vujA-5m8tA:
undetectable
5vujB-5m8tA:
0.0		 5vujA-5m8tA:
20.00
5vujB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.11A 5vukA-5m8tA:
undetectable
5vukB-5m8tA:
undetectable		 5vukA-5m8tA:
20.00
5vukB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5vukA-5m8tA:
undetectable
5vukB-5m8tA:
undetectable		 5vukA-5m8tA:
20.00
5vukB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5vulA-5m8tA:
undetectable
5vulB-5m8tA:
undetectable		 5vulA-5m8tA:
20.00
5vulB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5vulA-5m8tA:
undetectable
5vulB-5m8tA:
undetectable		 5vulA-5m8tA:
20.00
5vulB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUM_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5vumA-5m8tA:
undetectable
5vumB-5m8tA:
undetectable		 5vumA-5m8tA:
20.00
5vumB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUM_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 5vumA-5m8tA:
undetectable
5vumB-5m8tA:
undetectable		 5vumA-5m8tA:
20.00
5vumB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5vunA-5m8tA:
undetectable
5vunB-5m8tA:
undetectable		 5vunA-5m8tA:
20.00
5vunB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5vunA-5m8tA:
undetectable
5vunB-5m8tA:
undetectable		 5vunA-5m8tA:
20.00
5vunB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5vuoA-5m8tA:
undetectable
5vuoB-5m8tA:
undetectable		 5vuoA-5m8tA:
20.00
5vuoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5vuoA-5m8tA:
undetectable
5vuoB-5m8tA:
undetectable		 5vuoA-5m8tA:
20.00
5vuoB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5vupA-5m8tA:
undetectable
5vupB-5m8tA:
undetectable		 5vupA-5m8tA:
20.00
5vupB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5vupA-5m8tA:
undetectable
5vupB-5m8tA:
undetectable		 5vupA-5m8tA:
20.00
5vupB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 5vuqA-5m8tA:
undetectable
5vuqB-5m8tA:
undetectable		 5vuqA-5m8tA:
20.00
5vuqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5vuqA-5m8tA:
undetectable
5vuqB-5m8tA:
undetectable		 5vuqA-5m8tA:
20.00
5vuqB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 5vurA-5m8tA:
undetectable
5vurB-5m8tA:
undetectable		 5vurA-5m8tA:
20.00
5vurB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 5vusA-5m8tA:
undetectable
5vusB-5m8tA:
undetectable		 5vusA-5m8tA:
20.00
5vusB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5vusA-5m8tA:
undetectable
5vusB-5m8tA:
undetectable		 5vusA-5m8tA:
20.00
5vusB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5vutA-5m8tA:
undetectable
5vutB-5m8tA:
undetectable		 5vutA-5m8tA:
20.00
5vutB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5vutA-5m8tA:
undetectable
5vutB-5m8tA:
undetectable		 5vutA-5m8tA:
20.00
5vutB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 5vuuA-5m8tA:
undetectable
5vuuB-5m8tA:
undetectable		 5vuuA-5m8tA:
20.00
5vuuB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5vuuA-5m8tA:
undetectable
5vuuB-5m8tA:
undetectable		 5vuuA-5m8tA:
20.00
5vuuB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5vuvA-5m8tA:
undetectable
5vuvB-5m8tA:
undetectable		 5vuvA-5m8tA:
20.25
5vuvB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 5vuvA-5m8tA:
undetectable
5vuvB-5m8tA:
undetectable		 5vuvA-5m8tA:
20.25
5vuvB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5vuwA-5m8tA:
undetectable
5vuwB-5m8tA:
undetectable		 5vuwA-5m8tA:
20.25
5vuwB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 5vuwA-5m8tA:
undetectable
5vuwB-5m8tA:
undetectable		 5vuwA-5m8tA:
20.25
5vuwB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 5vuxA-5m8tA:
undetectable
5vuxB-5m8tA:
undetectable		 5vuxA-5m8tA:
20.25
5vuxB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 5vuyA-5m8tA:
undetectable
5vuyB-5m8tA:
undetectable		 5vuyA-5m8tA:
20.25
5vuyB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 5vuyA-5m8tA:
undetectable
5vuyB-5m8tA:
undetectable		 5vuyA-5m8tA:
20.25
5vuyB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 5vuzA-5m8tA:
undetectable
5vuzB-5m8tA:
undetectable		 5vuzA-5m8tA:
20.25
5vuzB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.04A 5vuzA-5m8tA:
undetectable
5vuzB-5m8tA:
undetectable		 5vuzA-5m8tA:
20.25
5vuzB-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 5vv0A-5m8tA:
undetectable
5vv0B-5m8tA:
undetectable		 5vv0A-5m8tA:
20.46
5vv0B-5m8tA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.11A 5vv0A-5m8tA:
undetectable
5vv0B-5m8tA:
undetectable		 5vv0A-5m8tA:
20.46
5vv0B-5m8tA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 5vv1A-5m8tA:
undetectable
5vv1B-5m8tA:
undetectable		 5vv1A-5m8tA:
20.25
5vv1B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5vv1A-5m8tA:
undetectable
5vv1B-5m8tA:
undetectable		 5vv1A-5m8tA:
20.25
5vv1B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 5vv2A-5m8tA:
undetectable
5vv2B-5m8tA:
undetectable		 5vv2A-5m8tA:
20.25
5vv2B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 5vv2A-5m8tA:
0.0
5vv2B-5m8tA:
undetectable		 5vv2A-5m8tA:
20.25
5vv2B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 5vv3A-5m8tA:
undetectable
5vv3B-5m8tA:
undetectable		 5vv3A-5m8tA:
20.25
5vv3B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 5vv3A-5m8tA:
undetectable
5vv3B-5m8tA:
undetectable		 5vv3A-5m8tA:
20.25
5vv3B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 5vv4A-5m8tA:
undetectable
5vv4B-5m8tA:
undetectable		 5vv4A-5m8tA:
20.25
5vv4B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5vv5A-5m8tA:
undetectable
5vv5B-5m8tA:
undetectable		 5vv5A-5m8tA:
20.25
5vv5B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 5vv5A-5m8tA:
undetectable
5vv5B-5m8tA:
undetectable		 5vv5A-5m8tA:
20.25
5vv5B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 5vv6A-5m8tA:
undetectable
5vv6B-5m8tA:
undetectable		 5vv6A-5m8tA:
21.75
5vv6B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5vv6A-5m8tA:
undetectable
5vv6B-5m8tA:
undetectable		 5vv6A-5m8tA:
21.75
5vv6B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5vv7A-5m8tA:
0.0
5vv7B-5m8tA:
0.5		 5vv7A-5m8tA:
21.75
5vv7B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 5vv7A-5m8tA:
undetectable
5vv7B-5m8tA:
undetectable		 5vv7A-5m8tA:
21.75
5vv7B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 5vv8A-5m8tA:
undetectable
5vv8B-5m8tA:
undetectable		 5vv8A-5m8tA:
21.75
5vv8B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 5vv8A-5m8tA:
undetectable
5vv8B-5m8tA:
undetectable		 5vv8A-5m8tA:
21.75
5vv8B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 5vv9A-5m8tA:
undetectable
5vv9B-5m8tA:
0.6		 5vv9A-5m8tA:
21.75
5vv9B-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 5vvaA-5m8tA:
undetectable
5vvaB-5m8tA:
undetectable		 5vvaA-5m8tA:
21.75
5vvaB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.01A 5vvaA-5m8tA:
undetectable
5vvaB-5m8tA:
undetectable		 5vvaA-5m8tA:
21.75
5vvaB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.00A 5vvbA-5m8tA:
0.0
5vvbB-5m8tA:
0.0		 5vvbA-5m8tA:
22.16
5vvbB-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 5vvbA-5m8tA:
0.0
5vvbB-5m8tA:
0.0		 5vvbA-5m8tA:
22.16
5vvbB-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5vvbC-5m8tA:
0.0
5vvbD-5m8tA:
0.0		 5vvbC-5m8tA:
22.16
5vvbD-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 5vvbC-5m8tA:
undetectable
5vvbD-5m8tA:
undetectable		 5vvbC-5m8tA:
22.16
5vvbD-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5vvcA-5m8tA:
undetectable
5vvcB-5m8tA:
0.0		 5vvcA-5m8tA:
22.16
5vvcB-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5vvcA-5m8tA:
0.0
5vvcB-5m8tA:
0.0		 5vvcA-5m8tA:
22.16
5vvcB-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.01A 5vvcC-5m8tA:
0.0
5vvcD-5m8tA:
0.0		 5vvcC-5m8tA:
22.16
5vvcD-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.02A 5vvcC-5m8tA:
undetectable
5vvcD-5m8tA:
undetectable		 5vvcC-5m8tA:
22.16
5vvcD-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 5vvdA-5m8tA:
0.0
5vvdB-5m8tA:
0.0		 5vvdA-5m8tA:
22.16
5vvdB-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.02A 5vvdA-5m8tA:
undetectable
5vvdB-5m8tA:
undetectable		 5vvdA-5m8tA:
22.16
5vvdB-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 5vvdC-5m8tA:
0.0
5vvdD-5m8tA:
undetectable		 5vvdC-5m8tA:
22.16
5vvdD-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 5vvgA-5m8tA:
0.3
5vvgB-5m8tA:
undetectable		 5vvgA-5m8tA:
21.75
5vvgB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.01A 5vvgA-5m8tA:
0.3
5vvgB-5m8tA:
undetectable		 5vvgA-5m8tA:
21.75
5vvgB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 5vvnA-5m8tA:
undetectable
5vvnB-5m8tA:
undetectable		 5vvnA-5m8tA:
21.75
5vvnB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 5vvnA-5m8tA:
undetectable
5vvnB-5m8tA:
undetectable		 5vvnA-5m8tA:
21.75
5vvnB-5m8tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.42A 5z0fA-5m8tA:
28.5
5z0fB-5m8tA:
undetectable		 5z0fA-5m8tA:
9.42
5z0fB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.41A 5z0fA-5m8tA:
28.5
5z0fB-5m8tA:
undetectable		 5z0fA-5m8tA:
9.42
5z0fB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.09A 5z0fA-5m8tA:
28.5
5z0fB-5m8tA:
undetectable		 5z0fA-5m8tA:
9.42
5z0fB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.47A 5z0fA-5m8tA:
28.5
5z0fB-5m8tA:
undetectable		 5z0fA-5m8tA:
9.42
5z0fB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.37A 5z0gA-5m8tA:
28.5
5z0gB-5m8tA:
undetectable		 5z0gA-5m8tA:
9.42
5z0gB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.45A 5z0gA-5m8tA:
28.5
5z0gB-5m8tA:
undetectable		 5z0gA-5m8tA:
9.42
5z0gB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.12A 5z0gA-5m8tA:
28.5
5z0gB-5m8tA:
undetectable		 5z0gA-5m8tA:
9.42
5z0gB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.49A 5z0gA-5m8tA:
28.5
5z0gB-5m8tA:
undetectable		 5z0gA-5m8tA:
9.42
5z0gB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.37A 5z0hA-5m8tA:
28.5
5z0hB-5m8tA:
undetectable		 5z0hA-5m8tA:
9.42
5z0hB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.37A 5z0hA-5m8tA:
28.5
5z0hB-5m8tA:
undetectable		 5z0hA-5m8tA:
9.42
5z0hB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.08A 5z0hA-5m8tA:
28.5
5z0hB-5m8tA:
undetectable		 5z0hA-5m8tA:
9.42
5z0hB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.42A 5z0hA-5m8tA:
28.5
5z0hB-5m8tA:
undetectable		 5z0hA-5m8tA:
9.42
5z0hB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.38A 5z0iA-5m8tA:
28.6
5z0iB-5m8tA:
undetectable		 5z0iA-5m8tA:
9.42
5z0iB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.41A 5z0iA-5m8tA:
28.6
5z0iB-5m8tA:
undetectable		 5z0iA-5m8tA:
9.42
5z0iB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 215
HIS A 192
HIS A 381
HIS A 377
ASP A 408
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
None
 1.43A 5z0iA-5m8tA:
28.6
5z0iB-5m8tA:
undetectable		 5z0iA-5m8tA:
9.42
5z0iB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.08A 5z0iA-5m8tA:
28.6
5z0iB-5m8tA:
undetectable		 5z0iA-5m8tA:
9.42
5z0iB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.46A 5z0iA-5m8tA:
28.6
5z0iB-5m8tA:
undetectable		 5z0iA-5m8tA:
9.42
5z0iB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.35A 5z0jA-5m8tA:
28.5
5z0jB-5m8tA:
undetectable		 5z0jA-5m8tA:
9.42
5z0jB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.43A 5z0jA-5m8tA:
28.5
5z0jB-5m8tA:
undetectable		 5z0jA-5m8tA:
9.42
5z0jB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 215
HIS A 192
HIS A 381
HIS A 377
ASP A 408
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
None
 1.47A 5z0jA-5m8tA:
28.5
5z0jB-5m8tA:
undetectable		 5z0jA-5m8tA:
9.42
5z0jB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 215
HIS A 192
HIS A 381
HIS A 404
HIS A 227
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
None
 1.48A 5z0jA-5m8tA:
28.5
5z0jB-5m8tA:
undetectable		 5z0jA-5m8tA:
9.42
5z0jB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.09A 5z0jA-5m8tA:
28.5
5z0jB-5m8tA:
undetectable		 5z0jA-5m8tA:
9.42
5z0jB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.47A 5z0jA-5m8tA:
28.5
5z0jB-5m8tA:
undetectable		 5z0jA-5m8tA:
9.42
5z0jB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.48A 5z0jA-5m8tA:
28.5
5z0jB-5m8tA:
undetectable		 5z0jA-5m8tA:
9.42
5z0jB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.33A 5z0kA-5m8tA:
28.6
5z0kB-5m8tA:
undetectable		 5z0kA-5m8tA:
9.42
5z0kB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.44A 5z0kA-5m8tA:
28.6
5z0kB-5m8tA:
undetectable		 5z0kA-5m8tA:
9.42
5z0kB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 215
HIS A 192
HIS A 381
HIS A 377
ASP A 408
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
None
 1.45A 5z0kA-5m8tA:
28.6
5z0kB-5m8tA:
undetectable		 5z0kA-5m8tA:
9.42
5z0kB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.11A 5z0kA-5m8tA:
28.6
5z0kB-5m8tA:
undetectable		 5z0kA-5m8tA:
9.42
5z0kB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.46A 5z0kA-5m8tA:
28.6
5z0kB-5m8tA:
undetectable		 5z0kA-5m8tA:
9.42
5z0kB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.47A 5z0kA-5m8tA:
28.6
5z0kB-5m8tA:
undetectable		 5z0kA-5m8tA:
9.42
5z0kB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.38A 5z0lA-5m8tA:
28.6
5z0lB-5m8tA:
undetectable		 5z0lA-5m8tA:
9.42
5z0lB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.39A 5z0lA-5m8tA:
28.6
5z0lB-5m8tA:
undetectable		 5z0lA-5m8tA:
9.42
5z0lB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.09A 5z0lA-5m8tA:
28.6
5z0lB-5m8tA:
undetectable		 5z0lA-5m8tA:
9.42
5z0lB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.42A 5z0lA-5m8tA:
28.6
5z0lB-5m8tA:
undetectable		 5z0lA-5m8tA:
9.42
5z0lB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.43A 5z0mA-5m8tA:
28.5
5z0mB-5m8tA:
undetectable		 5z0mA-5m8tA:
9.19
5z0mB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 192
HIS A 224
HIS A 377
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.28A 5z0mA-5m8tA:
28.5
5z0mB-5m8tA:
undetectable		 5z0mA-5m8tA:
9.19
5z0mB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.04A 5z0mA-5m8tA:
28.5
5z0mB-5m8tA:
undetectable		 5z0mA-5m8tA:
9.19
5z0mB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.36A 5z0mA-5m8tA:
28.5
5z0mB-5m8tA:
undetectable		 5z0mA-5m8tA:
9.19
5z0mB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 377
HIS A 381
HIS A 404
 ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
 0.12A 5zrdA-5m8tA:
9.7		 5zrdA-5m8tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 HIS A 377
HIS A 381
PHE A 400
HIS A 404
 ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
ZN  A 511 ( 4.7A)
ZN  A 511 (-3.1A)
 0.24A 5zrdB-5m8tA:
3.0		 5zrdB-5m8tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 HIS A 192
HIS A 215
HIS A 224
PHE A 400
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 4.7A)
 0.37A 5zrdB-5m8tA:
3.0		 5zrdB-5m8tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 HIS A 377
HIS A 381
HIS A 404
PHE A 220
 ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
None
 1.01A 5zrdB-5m8tA:
3.0		 5zrdB-5m8tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 HIS A 192
HIS A 215
HIS A 224
PHE A 400
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 4.7A)
 0.38A 5zrdC-5m8tA:
15.2		 5zrdC-5m8tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 HIS A 377
HIS A 381
HIS A 404
PHE A 220
 ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
None
 1.05A 5zrdC-5m8tA:
15.2		 5zrdC-5m8tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 HIS A 192
HIS A 215
HIS A 224
PHE A 400
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 4.7A)
 0.37A 5zrdD-5m8tA:
4.3		 5zrdD-5m8tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 HIS A 377
HIS A 381
HIS A 404
PHE A 220
 ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
None
 1.01A 5zrdD-5m8tA:
4.3		 5zrdD-5m8tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 6auqA-5m8tA:
undetectable
6auqB-5m8tA:
undetectable		 6auqA-5m8tA:
11.81
6auqB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 6auqA-5m8tA:
undetectable
6auqB-5m8tA:
undetectable		 6auqA-5m8tA:
11.81
6auqB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 6aurA-5m8tA:
undetectable
6aurB-5m8tA:
undetectable		 6aurA-5m8tA:
11.81
6aurB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 6aurA-5m8tA:
undetectable
6aurB-5m8tA:
undetectable		 6aurA-5m8tA:
11.81
6aurB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 6ausA-5m8tA:
undetectable
6ausB-5m8tA:
undetectable		 6ausA-5m8tA:
11.81
6ausB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 6ausA-5m8tA:
undetectable
6ausB-5m8tA:
undetectable		 6ausA-5m8tA:
11.81
6ausB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 6autA-5m8tA:
undetectable
6autB-5m8tA:
undetectable		 6autA-5m8tA:
11.81
6autB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 6autA-5m8tA:
undetectable
6autB-5m8tA:
undetectable		 6autA-5m8tA:
11.81
6autB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 6auuA-5m8tA:
undetectable
6auuB-5m8tA:
undetectable		 6auuA-5m8tA:
11.81
6auuB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 6auuA-5m8tA:
undetectable
6auuB-5m8tA:
undetectable		 6auuA-5m8tA:
11.81
6auuB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 6auvA-5m8tA:
undetectable
6auvB-5m8tA:
0.0		 6auvA-5m8tA:
11.81
6auvB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 6auvA-5m8tA:
undetectable
6auvB-5m8tA:
undetectable		 6auvA-5m8tA:
11.81
6auvB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 6auwA-5m8tA:
0.0
6auwB-5m8tA:
undetectable		 6auwA-5m8tA:
11.81
6auwB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 6auwA-5m8tA:
undetectable
6auwB-5m8tA:
undetectable		 6auwA-5m8tA:
11.81
6auwB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 6auxA-5m8tA:
undetectable
6auxB-5m8tA:
undetectable		 6auxA-5m8tA:
11.81
6auxB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 6auxA-5m8tA:
undetectable
6auxB-5m8tA:
undetectable		 6auxA-5m8tA:
11.81
6auxB-5m8tA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 6auyA-5m8tA:
undetectable
6auyB-5m8tA:
undetectable		 6auyA-5m8tA:
11.57
6auyB-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 6auyA-5m8tA:
0.0
6auyB-5m8tA:
undetectable		 6auyA-5m8tA:
11.57
6auyB-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 6auzA-5m8tA:
undetectable
6auzB-5m8tA:
undetectable		 6auzA-5m8tA:
11.57
6auzB-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 6auzA-5m8tA:
undetectable
6auzB-5m8tA:
undetectable		 6auzA-5m8tA:
11.57
6auzB-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 6av0A-5m8tA:
undetectable
6av0B-5m8tA:
undetectable		 6av0A-5m8tA:
11.57
6av0B-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 6av0A-5m8tA:
undetectable
6av0B-5m8tA:
undetectable		 6av0A-5m8tA:
11.57
6av0B-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.06A 6av1A-5m8tA:
undetectable
6av1B-5m8tA:
undetectable		 6av1A-5m8tA:
11.57
6av1B-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 6av1A-5m8tA:
undetectable
6av1B-5m8tA:
undetectable		 6av1A-5m8tA:
11.57
6av1B-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 6av2A-5m8tA:
undetectable
6av2B-5m8tA:
undetectable		 6av2A-5m8tA:
11.57
6av2B-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 6av2A-5m8tA:
undetectable
6av2B-5m8tA:
undetectable		 6av2A-5m8tA:
11.57
6av2B-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 6av3A-5m8tA:
undetectable
6av3B-5m8tA:
undetectable		 6av3A-5m8tA:
11.57
6av3B-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 6av3A-5m8tA:
undetectable
6av3B-5m8tA:
undetectable		 6av3A-5m8tA:
11.57
6av3B-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 6av4A-5m8tA:
undetectable
6av4B-5m8tA:
undetectable		 6av4A-5m8tA:
11.57
6av4B-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.07A 6av4A-5m8tA:
undetectable
6av4B-5m8tA:
undetectable		 6av4A-5m8tA:
11.57
6av4B-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.08A 6av5A-5m8tA:
undetectable
6av5B-5m8tA:
undetectable		 6av5A-5m8tA:
11.57
6av5B-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 6av5A-5m8tA:
undetectable
6av5B-5m8tA:
undetectable		 6av5A-5m8tA:
11.57
6av5B-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.10A 6av6A-5m8tA:
undetectable
6av6B-5m8tA:
undetectable		 6av6A-5m8tA:
10.72
6av6B-5m8tA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.01A 6av6C-5m8tA:
undetectable
6av6D-5m8tA:
undetectable		 6av6C-5m8tA:
10.72
6av6D-5m8tA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.11A 6av6C-5m8tA:
undetectable
6av6D-5m8tA:
undetectable		 6av6C-5m8tA:
10.72
6av6D-5m8tA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 6av7A-5m8tA:
0.0
6av7B-5m8tA:
undetectable		 6av7A-5m8tA:
10.72
6av7B-5m8tA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.02A 6av7C-5m8tA:
0.0
6av7D-5m8tA:
undetectable		 6av7C-5m8tA:
10.72
6av7D-5m8tA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 6av7C-5m8tA:
0.0
6av7D-5m8tA:
undetectable		 6av7C-5m8tA:
10.72
6av7D-5m8tA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 12 ASP A 212
SER A 214
ASN A 378
SER A 374
VAL A 391
 None
None
0TR  A 513 ( 4.4A)
None
0TR  A 513 (-3.8A)
 1.12A 6bqgA-5m8tA:
undetectable		 6bqgA-5m8tA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 12 HIS A 381
PHE A 400
LEU A 293
THR A 387
GLY A 388
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 4.7A)
None
None
None
 0.91A 6brdA-5m8tA:
undetectable		 6brdA-5m8tA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 12 HIS A 381
PHE A 400
THR A 387
GLY A 388
GLY A 389
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 4.7A)
None
None
0TR  A 513 (-3.8A)
 0.95A 6brdB-5m8tA:
undetectable		 6brdB-5m8tA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.09A 6cicA-5m8tA:
undetectable
6cicB-5m8tA:
undetectable		 6cicA-5m8tA:
11.57
6cicB-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.08A 6cicA-5m8tA:
undetectable
6cicB-5m8tA:
undetectable		 6cicA-5m8tA:
11.57
6cicB-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.07A 6cidA-5m8tA:
undetectable
6cidB-5m8tA:
undetectable		 6cidA-5m8tA:
11.57
6cidB-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 7 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.09A 6cidA-5m8tA:
undetectable
6cidB-5m8tA:
undetectable		 6cidA-5m8tA:
11.57
6cidB-5m8tA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.00A 6cieC-5m8tA:
undetectable
6cieD-5m8tA:
undetectable		 6cieC-5m8tA:
10.72
6cieD-5m8tA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_A_H4BA502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 6cifA-5m8tA:
undetectable
6cifB-5m8tA:
0.0		 6cifA-5m8tA:
10.72
6cifB-5m8tA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 6cifC-5m8tA:
0.0
6cifD-5m8tA:
undetectable		 6cifC-5m8tA:
10.72
6cifD-5m8tA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 10 LEU A 133
LEU A 148
ASP A 149
LYS A 152
ILE A 260
 None
 1.46A 6dlzB-5m8tA:
undetectable
6dlzC-5m8tA:
undetectable		 6dlzB-5m8tA:
10.31
6dlzC-5m8tA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 10 LEU A 133
LEU A 148
ASP A 149
LYS A 152
ILE A 260
 None
 1.46A 6dm1B-5m8tA:
undetectable
6dm1C-5m8tA:
undetectable		 6dm1B-5m8tA:
10.31
6dm1C-5m8tA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 10 LEU A 133
LEU A 148
ASP A 149
LYS A 152
ILE A 260
 None
 1.44A 6dm2B-5m8tA:
undetectable
6dm2C-5m8tA:
undetectable		 6dm2B-5m8tA:
10.31
6dm2C-5m8tA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 10 ILE A 260
LEU A 133
LEU A 148
ASP A 149
LYS A 152
 None
 1.45A 6dm2A-5m8tA:
undetectable
6dm2D-5m8tA:
undetectable		 6dm2A-5m8tA:
10.31
6dm2D-5m8tA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		3 / 3 ASP A 297
ASP A 212
ASN A 449
 None
 0.86A 6gngB-5m8tA:
undetectable		 6gngB-5m8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.04A 8nseA-5m8tA:
undetectable
8nseB-5m8tA:
undetectable		 8nseA-5m8tA:
21.55
8nseB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 8nseA-5m8tA:
undetectable
8nseB-5m8tA:
undetectable		 8nseA-5m8tA:
21.55
8nseB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 9nseA-5m8tA:
undetectable
9nseB-5m8tA:
undetectable		 9nseA-5m8tA:
21.55
9nseB-5m8tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 6 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.03A 9nseA-5m8tA:
undetectable
9nseB-5m8tA:
undetectable		 9nseA-5m8tA:
21.55
9nseB-5m8tA:
21.55