SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m95'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		4 / 8 SER A 234
ASN A 423
MET A  84
LEU A  96
 None
 1.10A 1lhvA-5m95A:
undetectable		 1lhvA-5m95A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		5 / 12 ILE A 372
ILE A 369
LEU A 371
LEU A 384
ILE A 129
 None
 1.21A 1xzxX-5m95A:
undetectable		 1xzxX-5m95A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		4 / 7 SER A 434
GLY A 222
THR A 224
ILE A  71
 None
 1.02A 2bdmA-5m95A:
undetectable		 2bdmA-5m95A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		4 / 6 SER A 330
GLY A 334
THR A 335
ARG A 356
 None
 1.22A 2f7fA-5m95A:
undetectable		 2f7fA-5m95A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		4 / 7 ALA A 122
THR A 123
ALA A 126
PRO A 227
 None
 0.86A 2ql8A-5m95A:
undetectable
2ql8B-5m95A:
undetectable		 2ql8A-5m95A:
16.67
2ql8B-5m95A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		4 / 6 TRP A  53
GLY A 130
GLY A 293
PHE A 319
 None
 1.04A 2qx6A-5m95A:
undetectable
2qx6B-5m95A:
undetectable		 2qx6A-5m95A:
19.85
2qx6B-5m95A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		5 / 12 ALA A 134
ILE A 141
ILE A 144
ILE A 381
TYR A 295
 None
 1.08A 3clbB-5m95A:
undetectable		 3clbB-5m95A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		5 / 12 THR A 123
ALA A 126
LEU A 385
LEU A 384
LEU A 392
 None
 1.11A 3hm1A-5m95A:
undetectable		 3hm1A-5m95A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		5 / 12 LEU A 323
ALA A 126
GLY A 130
SER A 131
LEU A 385
 None
 1.10A 3ou6C-5m95A:
undetectable		 3ou6C-5m95A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		5 / 12 LEU A 323
ALA A 126
GLY A 130
SER A 131
LEU A 385
 None
 1.11A 3ou7B-5m95A:
undetectable		 3ou7B-5m95A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		5 / 12 LEU A 323
ALA A 126
GLY A 130
SER A 131
LEU A 385
 None
 1.11A 3ou7C-5m95A:
undetectable		 3ou7C-5m95A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		3 / 3 HIS A 228
SER A 388
ASN A  52
 None
None
MN  A 501 (-3.0A)
 0.81A 3s8pB-5m95A:
undetectable		 3s8pB-5m95A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		5 / 12 LEU A 346
ILE A 358
GLY A 338
ILE A 350
ILE A 340
 None
 1.03A 3uj6A-5m95A:
undetectable		 3uj6A-5m95A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		4 / 5 LEU A 278
LEU A 275
LEU A 180
MET A 315
 None
 0.93A 3vhuA-5m95A:
undetectable		 3vhuA-5m95A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		3 / 3 ASP A 136
TRP A  53
SER A 378
 None
 1.07A 4lrhA-5m95A:
undetectable		 4lrhA-5m95A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		5 / 12 MET A 226
GLY A 334
TYR A 231
ILE A 332
GLN A 328
 MN  A 501 (-2.6A)
None
None
None
None
 1.42A 4xucA-5m95A:
undetectable		 4xucA-5m95A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		3 / 3 HIS A 228
SER A 388
ASN A  52
 None
None
MN  A 501 (-3.0A)
 0.87A 5cprB-5m95A:
undetectable		 5cprB-5m95A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		4 / 4 VAL A 390
ALA A 223
ILE A 216
THR A  55
 None
MN  A 501 (-3.9A)
None
None
 1.16A 5e4dB-5m95A:
undetectable		 5e4dB-5m95A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		5 / 12 LEU A 274
GLU A 186
VAL A 184
THR A 286
GLY A 285
 None
 1.25A 5xiqD-5m95A:
undetectable		 5xiqD-5m95A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH
(Staphylococcus
capitis) 		4 / 6 GLY A 285
ASP A 290
GLY A  64
GLY A  60
 None
 0.68A 6ag0C-5m95A:
undetectable		 6ag0C-5m95A:
11.63