SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 7 HIS A 286
HIS A 322
HIS A 288
THR A 422
 KCX  A 193 ( 4.3A)
CAP  A 501 (-4.0A)
CAP  A 501 (-3.8A)
KCX  A 193 ( 3.7A)
 0.80A 1am6A-5macA:
undetectable		 1am6A-5macA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 10 LEU A 407
ALA A 440
VAL A 427
GLY A 187
GLY A 188
 None
 0.99A 1k6cA-5macA:
undetectable		 1k6cA-5macA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 8 ASP A  26
LEU A  34
TRP A 131
GLY A  30
 None
 0.98A 1rmtC-5macA:
undetectable		 1rmtC-5macA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 12 MET A 217
VAL A 210
VAL A 213
TYR A 206
TYR A 259
 None
 1.33A 1wopA-5macA:
0.4		 1wopA-5macA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 7 ARG A 151
ILE A 397
GLY A 163
PHE A 191
 None
None
None
KCX  A 193 ( 4.8A)
 0.89A 2tsrA-5macA:
undetectable		 2tsrA-5macA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 11 HIS A 322
ALA A 313
VAL A 306
GLY A 265
ILE A 266
 CAP  A 501 (-4.0A)
None
None
None
None
 1.25A 2uxpB-5macA:
undetectable		 2uxpB-5macA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 GLN A 435
ALA A 216
ALA A 220
THR A 224
 None
 1.01A 2xfhA-5macA:
undetectable		 2xfhA-5macA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 5 GLU A 375
ARG A 389
ASP A 376
ASP A 418
 None
 1.33A 2yqzA-5macA:
undetectable		 2yqzA-5macA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 5 GLU A 375
ARG A 389
ASP A 376
ASP A 418
 None
 1.32A 2yqzB-5macA:
undetectable		 2yqzB-5macA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 11 HIS A 322
ILE A 397
HIS A 286
SER A 399
ASP A 190
 CAP  A 501 (-4.0A)
None
KCX  A 193 ( 4.3A)
CAP  A 501 (-3.2A)
None
 1.26A 2zweA-5macA:
undetectable
2zweB-5macA:
undetectable		 2zweA-5macA:
21.47
2zweB-5macA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 7 GLY A 189
VAL A 442
ILE A 161
GLN A 226
 None
 0.91A 3fi0P-5macA:
undetectable		 3fi0P-5macA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 5 VAL A 339
ILE A 345
TYR A 145
MET A 150
 None
 1.31A 3gvuA-5macA:
undetectable		 3gvuA-5macA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 8 PHE A 354
GLU A 337
SER A 305
ARG A  87
 None
 1.38A 3jx1A-5macA:
0.7
3jx1B-5macA:
undetectable		 3jx1A-5macA:
21.76
3jx1B-5macA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 ILE A  92
VAL A  90
LEU A  83
LEU A  22
 None
None
None
CL  A 504 (-3.9A)
 0.87A 3kp6A-5macA:
undetectable
3kp6B-5macA:
undetectable		 3kp6A-5macA:
14.48
3kp6B-5macA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 11 VAL A 398
LEU A 402
ILE A 328
GLY A 327
ALA A 326
 None
 1.17A 3n8yA-5macA:
undetectable		 3n8yA-5macA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 8 PHE A 354
GLU A 337
SER A 305
ARG A  87
 None
 1.37A 3nlyA-5macA:
undetectable
3nlyB-5macA:
0.0		 3nlyA-5macA:
20.99
3nlyB-5macA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 5 LEU A 441
ILE A 161
PRO A 160
PHE A 419
 None
 1.05A 3s3vA-5macA:
undetectable		 3s3vA-5macA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 12 GLY A 317
GLY A 320
ASP A 141
PHE A 132
GLN A 274
 None
 1.25A 3tkaA-5macA:
undetectable		 3tkaA-5macA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 THR A 267
GLY A 269
ARG A 245
ILE A 263
 None
 1.22A 4ac9C-5macA:
2.1		 4ac9C-5macA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 THR A 267
GLY A 269
ARG A 245
ILE A 263
 None
 1.22A 4acaC-5macA:
undetectable		 4acaC-5macA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 8 PHE A 354
GLU A 337
SER A 305
ARG A  87
 None
 1.34A 4capA-5macA:
0.5
4capB-5macA:
undetectable		 4capA-5macA:
20.99
4capB-5macA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 8 PHE A 354
GLU A 337
SER A 305
ARG A  87
 None
 1.34A 4d32A-5macA:
undetectable
4d32B-5macA:
0.7		 4d32A-5macA:
20.99
4d32B-5macA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		3 / 3 ARG A  87
LEU A  89
GLU A  88
 None
 0.74A 4l3gF-5macA:
undetectable		 4l3gF-5macA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 8 MET A 209
ALA A 211
VAL A 283
PHE A 261
 None
 0.98A 4ltwA-5macA:
undetectable		 4ltwA-5macA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 ILE A 266
ILE A 321
SER A 310
PHE A 304
 None
 0.81A 4m51A-5macA:
4.1		 4m51A-5macA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 10 TYR A 206
VAL A 213
ALA A 178
PHE A 232
SER A 174
 None
 1.36A 4mmdA-5macA:
undetectable		 4mmdA-5macA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 8 HIS A 286
HIS A 322
HIS A 288
THR A 422
 KCX  A 193 ( 4.3A)
CAP  A 501 (-4.0A)
CAP  A 501 (-3.8A)
KCX  A 193 ( 3.7A)
 0.81A 4n16A-5macA:
undetectable		 4n16A-5macA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 ILE A 165
ASP A 195
GLY A 400
HIS A 288
 CAP  A 501 (-3.7A)
MG  A 502 ( 3.0A)
CAP  A 501 (-3.0A)
CAP  A 501 (-3.8A)
 0.87A 4oltA-5macA:
undetectable		 4oltA-5macA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 ILE A 165
ASP A 195
GLY A 400
HIS A 288
 CAP  A 501 (-3.7A)
MG  A 502 ( 3.0A)
CAP  A 501 (-3.0A)
CAP  A 501 (-3.8A)
 0.87A 4oltB-5macA:
undetectable		 4oltB-5macA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 12 LEU A 262
THR A 422
ILE A 397
HIS A 322
ILE A 165
 None
KCX  A 193 ( 3.7A)
None
CAP  A 501 (-4.0A)
CAP  A 501 (-3.7A)
 1.19A 4rp8C-5macA:
undetectable		 4rp8C-5macA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 TYR A 259
GLU A 247
TYR A 280
LEU A 276
 None
 1.30A 4twdB-5macA:
undetectable
4twdC-5macA:
undetectable		 4twdB-5macA:
19.54
4twdC-5macA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 TYR A 259
GLU A 247
TYR A 280
LEU A 276
 None
 1.29A 4twdD-5macA:
undetectable
4twdE-5macA:
undetectable		 4twdD-5macA:
19.54
4twdE-5macA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 8 PHE A 354
GLU A 337
SER A 305
ARG A  87
 None
 1.35A 4v3yA-5macA:
undetectable
4v3yB-5macA:
undetectable		 4v3yA-5macA:
20.99
4v3yB-5macA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 7 ARG A 389
ILE A 382
ILE A 362
ASP A 366
 None
None
None
MG  A 503 (-2.2A)
 1.00A 4w5oA-5macA:
undetectable		 4w5oA-5macA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 ARG A 389
ILE A 382
ILE A 362
ASP A 366
 None
None
None
MG  A 503 (-2.2A)
 1.00A 4w5qA-5macA:
undetectable		 4w5qA-5macA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 ARG A 389
ILE A 382
ILE A 362
ASP A 366
 None
None
None
MG  A 503 (-2.2A)
 1.01A 4w5tA-5macA:
undetectable		 4w5tA-5macA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 11 PHE A 184
ALA A 440
GLY A 163
VAL A 427
GLY A 437
 None
 1.16A 4xnxA-5macA:
undetectable		 4xnxA-5macA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 ARG A 389
ILE A 382
ILE A 362
ASP A 366
 None
None
None
MG  A 503 (-2.2A)
 1.01A 4z4cA-5macA:
undetectable		 4z4cA-5macA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 ARG A 389
ILE A 382
ILE A 362
ASP A 366
 None
None
None
MG  A 503 (-2.2A)
 0.99A 4z4dA-5macA:
undetectable		 4z4dA-5macA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 7 ARG A 389
ILE A 382
ILE A 362
ASP A 366
 None
None
None
MG  A 503 (-2.2A)
 1.02A 4z4eA-5macA:
undetectable		 4z4eA-5macA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 7 ARG A 389
ILE A 382
ILE A 362
ASP A 366
 None
None
None
MG  A 503 (-2.2A)
 1.00A 4z4gA-5macA:
undetectable		 4z4gA-5macA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 5 GLU A  53
ALA A  56
GLU A  57
ASN A  63
 None
 1.31A 5dwkC-5macA:
undetectable		 5dwkC-5macA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 12 LEU A 315
ALA A 316
LEU A 109
ILE A 266
GLY A 265
 None
 1.07A 5gs4A-5macA:
undetectable		 5gs4A-5macA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 12 LEU A 315
ALA A 316
LEU A 109
ILE A 266
GLY A 265
 None
 1.11A 5gtrA-5macA:
undetectable		 5gtrA-5macA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 12 GLY A 426
ILE A 454
LEU A 464
LEU A 441
ALA A 444
 None
 1.04A 5l0zA-5macA:
3.3		 5l0zA-5macA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 5 LEU A  12
TYR A  19
LYS A  15
GLU A  53
 None
 1.33A 5weaA-5macA:
undetectable		 5weaA-5macA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_A_ASCA501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 10 HIS A 286
ILE A 397
HIS A 322
ALA A 290
ILE A 165
 KCX  A 193 ( 4.3A)
None
CAP  A 501 (-4.0A)
None
CAP  A 501 (-3.7A)
 1.20A 5zovA-5macA:
undetectable		 5zovA-5macA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 12 HIS A 286
ILE A 397
HIS A 322
ALA A 290
ILE A 165
 KCX  A 193 ( 4.3A)
None
CAP  A 501 (-4.0A)
None
CAP  A 501 (-3.7A)
 1.20A 5zovB-5macA:
undetectable		 5zovB-5macA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 7 PHE A  99
ARG A 101
ARG A  97
LEU A  98
 None
 1.30A 6b89A-5macA:
undetectable		 6b89A-5macA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		4 / 6 ARG A 389
ILE A 382
ILE A 362
ASP A 366
 None
None
None
MG  A 503 (-2.2A)
 1.04A 6cbdA-5macA:
undetectable		 6cbdA-5macA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III
(Methanococcoides
burtonii) 		5 / 11 THR A 422
PHE A 191
SER A 231
ALA A 260
ALA A 313
 KCX  A 193 ( 3.7A)
KCX  A 193 ( 4.8A)
KCX  A 193 ( 4.6A)
None
None
 1.40A 6efnA-5macA:
5.5		 6efnA-5macA:
22.42