SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mak'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5mak R7
(synthetic
construct) 		5 / 11 ALA A 137
HIS A 118
GLU A 130
LEU A 126
LEU A 165
 None
None
None
CIT  A 401 (-4.4A)
None
 1.18A 1mjlA-5makA:
undetectable
1mjlB-5makA:
undetectable		 1mjlA-5makA:
13.65
1mjlB-5makA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5mak R7
(synthetic
construct) 		5 / 11 ALA A 274
HIS A 255
GLU A 267
ALA A 258
LEU A 302
 None
 1.34A 1mjlA-5makA:
undetectable
1mjlB-5makA:
undetectable		 1mjlA-5makA:
13.65
1mjlB-5makA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5mak R7
(synthetic
construct) 		5 / 11 ALA A 274
HIS A 255
GLU A 267
LEU A 263
LEU A 302
 None
 1.13A 1mjlA-5makA:
undetectable
1mjlB-5makA:
undetectable		 1mjlA-5makA:
13.65
1mjlB-5makA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5mak R7
(synthetic
construct) 		4 / 7 VAL A 243
VAL A 276
ASN A 272
GLY A 273
 None
 0.94A 3kmoB-5makA:
undetectable		 3kmoB-5makA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5mak R7
(synthetic
construct) 		5 / 12 ILE A 161
VAL A  96
ILE A 128
GLU A  97
GLU A  94
 None
 1.20A 4i41A-5makA:
undetectable		 4i41A-5makA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5mak R7
(synthetic
construct) 		5 / 12 ILE A 298
VAL A 233
ILE A 265
GLU A 234
GLU A 231
 None
 1.28A 4i41A-5makA:
undetectable		 4i41A-5makA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5mak R7
(synthetic
construct) 		5 / 9 ALA A  43
ASP A  39
LEU A  18
GLY A  15
LEU A  19
 None
 1.21A 5dqfA-5makA:
undetectable		 5dqfA-5makA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5mak R7
(synthetic
construct) 		5 / 12 LEU A  51
ALA A  71
ASN A 102
ILE A  62
ALA A  54
 None
 1.30A 5eypB-5makA:
undetectable		 5eypB-5makA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5mak R7
(synthetic
construct) 		5 / 12 LEU A  51
ALA A  71
ASN A 102
ILE A  62
ALA A  54
 None
 1.24A 5nm5B-5makA:
undetectable		 5nm5B-5makA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 5mak R7
(synthetic
construct) 		4 / 7 GLN A 142
GLY A 146
PHE A 145
VAL A 184
 None
 0.96A 6hu9S-5makA:
undetectable
6hu9q-5makA:
undetectable		 6hu9S-5makA:
17.31
6hu9q-5makA:
19.37