SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5mal LIPASE
(Streptomyces
rimosus) 		4 / 8 ILE A 112
VAL A 188
ASN A 171
LEU A 120
 None
 0.96A 1dzmA-5malA:
undetectable		 1dzmA-5malA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 9 THR A 174
LEU A 120
VAL A 123
ILE A 127
VAL A 136
 None
 1.37A 1gebA-5malA:
undetectable		 1gebA-5malA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 12 LEU A 230
TYR A  34
GLY A 186
TYR A 226
GLY A 140
 None
 1.11A 1httB-5malA:
2.9		 1httB-5malA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 12 LEU A 230
TYR A  34
GLY A 186
TYR A 226
GLY A 140
 None
 1.16A 1httC-5malA:
2.8		 1httC-5malA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 9 THR A 174
LEU A 120
VAL A 123
VAL A 136
VAL A  75
 None
 1.34A 1iwjA-5malA:
undetectable		 1iwjA-5malA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 12 ILE A  79
ASP A  83
LEU A  65
GLY A  80
LEU A   7
 None
 1.05A 1liiA-5malA:
4.5		 1liiA-5malA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 10 THR A 174
LEU A 120
VAL A 123
VAL A 136
VAL A  75
 None
 1.31A 1o76A-5malA:
undetectable		 1o76A-5malA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 12 ALA A  17
GLY A  14
TYR A  11
LEU A 139
HIS A 205
 None
 1.23A 1qabF-5malA:
undetectable		 1qabF-5malA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKW_A_PNTA225_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 12 TYR A  11
GLU A 196
TYR A 145
VAL A 188
ASN A 189
 None
 1.45A 1rkwA-5malA:
0.4		 1rkwA-5malA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5mal LIPASE
(Streptomyces
rimosus) 		4 / 7 VAL A 138
VAL A 188
TYR A 215
ARG A 177
 None
 1.04A 1t46A-5malA:
undetectable		 1t46A-5malA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 10 THR A 174
LEU A 120
VAL A 123
VAL A 136
VAL A  75
 None
 1.35A 2cp4A-5malA:
undetectable		 2cp4A-5malA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 12 GLY A  14
ALA A  51
THR A  50
ALA A  36
PHE A  47
 None
 1.02A 2gluB-5malA:
3.3		 2gluB-5malA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 5mal LIPASE
(Streptomyces
rimosus) 		4 / 7 ARG A  56
GLY A  80
ILE A 170
GLN A  64
 None
 1.12A 4g0vA-5malA:
undetectable		 4g0vA-5malA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 12 ASP A   9
TYR A  11
SER A  13
ALA A  17
ASN A 213
 None
 1.47A 4u15A-5malA:
undetectable		 4u15A-5malA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 5mal LIPASE
(Streptomyces
rimosus) 		4 / 7 SER A  12
TYR A  34
TYR A  11
PRO A 217
 None
 0.78A 5aclA-5malA:
undetectable		 5aclA-5malA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5mal LIPASE
(Streptomyces
rimosus) 		4 / 5 SER A  41
ALA A  40
HIS A  42
LEU A 227
 None
 1.06A 5dzkb-5malA:
undetectable
5dzkp-5malA:
undetectable		 5dzkb-5malA:
23.20
5dzkp-5malA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5mal LIPASE
(Streptomyces
rimosus) 		4 / 5 SER A  41
ALA A  40
HIS A  42
LEU A 227
 None
 1.09A 5dzkc-5malA:
undetectable
5dzkq-5malA:
undetectable		 5dzkc-5malA:
23.20
5dzkq-5malA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5mal LIPASE
(Streptomyces
rimosus) 		4 / 7 SER A  41
ALA A  40
HIS A  42
LEU A 227
 None
 1.08A 5dzkD-5malA:
undetectable
5dzkR-5malA:
undetectable		 5dzkD-5malA:
23.20
5dzkR-5malA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5mal LIPASE
(Streptomyces
rimosus) 		4 / 5 SER A  41
ALA A  40
HIS A  42
LEU A 227
 None
 1.01A 5dzkf-5malA:
2.3
5dzkt-5malA:
undetectable		 5dzkf-5malA:
23.20
5dzkt-5malA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5mal LIPASE
(Streptomyces
rimosus) 		4 / 8 SER A  41
ALA A  40
HIS A  42
LEU A 227
 None
 1.04A 5dzkF-5malA:
2.2
5dzkT-5malA:
undetectable		 5dzkF-5malA:
23.20
5dzkT-5malA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5mal LIPASE
(Streptomyces
rimosus) 		4 / 6 SER A  41
ALA A  40
HIS A  42
LEU A 227
 None
 1.02A 5dzkg-5malA:
undetectable
5dzku-5malA:
undetectable		 5dzkg-5malA:
23.20
5dzku-5malA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 12 LEU A 230
TYR A  34
GLY A 186
TYR A 226
GLY A 140
 None
 1.12A 5e3iA-5malA:
2.2		 5e3iA-5malA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 5mal LIPASE
(Streptomyces
rimosus) 		5 / 12 ARG A 104
THR A  89
ILE A 112
PHE A  86
ASN A  82
 None
 1.35A 5hgcA-5malA:
undetectable		 5hgcA-5malA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5mal LIPASE
(Streptomyces
rimosus) 		4 / 7 GLY A  85
GLN A  64
ASP A   9
TYR A  11
 None
 1.19A 5vlmG-5malA:
undetectable		 5vlmG-5malA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 5mal LIPASE
(Streptomyces
rimosus) 		4 / 4 ILE A  79
LEU A  65
HIS A 181
ALA A 126
 None
 0.95A 6ck2C-5malA:
undetectable
6ck2D-5malA:
undetectable		 6ck2C-5malA:
8.62
6ck2D-5malA:
8.55