SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5map'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5map DTPA
(Streptomyces
lividans) 		4 / 7 GLN A  95
THR A 151
SER A 149
TRP A 393
 None
 1.04A 1eiiA-5mapA:
undetectable		 1eiiA-5mapA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5map DTPA
(Streptomyces
lividans) 		5 / 12 GLY A 155
VAL A 101
PHE A 156
LEU A 442
PHE A 103
 None
 1.22A 1nw3A-5mapA:
undetectable		 1nw3A-5mapA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5map DTPA
(Streptomyces
lividans) 		5 / 11 PHE A 390
VAL A 290
GLY A 400
LEU A 177
PHE A 180
 HEM  A 901 (-3.8A)
None
None
None
None
 0.83A 1z11A-5mapA:
undetectable		 1z11A-5mapA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5map DTPA
(Streptomyces
lividans) 		5 / 11 PHE A 390
VAL A 290
GLY A 400
LEU A 177
PHE A 180
 HEM  A 901 (-3.8A)
None
None
None
None
 0.85A 1z11B-5mapA:
undetectable		 1z11B-5mapA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5map DTPA
(Streptomyces
lividans) 		5 / 10 PHE A 390
VAL A 290
GLY A 400
LEU A 177
PHE A 180
 HEM  A 901 (-3.8A)
None
None
None
None
 0.85A 1z11C-5mapA:
undetectable		 1z11C-5mapA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5map DTPA
(Streptomyces
lividans) 		5 / 10 PHE A 390
VAL A 290
GLY A 400
LEU A 177
PHE A 180
 HEM  A 901 (-3.8A)
None
None
None
None
 0.85A 1z11D-5mapA:
undetectable		 1z11D-5mapA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 5map DTPA
(Streptomyces
lividans) 		4 / 6 TRP A 282
GLY A 157
PHE A 160
SER A 159
 None
 1.29A 2a3cA-5mapA:
undetectable		 2a3cA-5mapA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5map DTPA
(Streptomyces
lividans) 		5 / 9 SER A 122
ARG A 119
VAL A 438
ALA A 114
ALA A 115
 None
 1.33A 3ax7B-5mapA:
0.7		 3ax7B-5mapA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 5map DTPA
(Streptomyces
lividans) 		3 / 3 PRO A  88
PHE A 154
ALA A 125
 None
 0.56A 3itaD-5mapA:
undetectable		 3itaD-5mapA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5map DTPA
(Streptomyces
lividans) 		4 / 6 VAL A 289
VAL A 368
TRP A 393
PHE A 268
 None
 1.48A 3jx4A-5mapA:
undetectable
3jx4B-5mapA:
undetectable		 3jx4A-5mapA:
21.19
3jx4B-5mapA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5map DTPA
(Streptomyces
lividans) 		4 / 8 GLY A 155
PHE A 263
GLY A 286
PHE A 268
 None
 0.69A 3ko0O-5mapA:
undetectable
3ko0Q-5mapA:
undetectable		 3ko0O-5mapA:
15.99
3ko0Q-5mapA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5map DTPA
(Streptomyces
lividans) 		4 / 4 VAL A 291
PHE A 426
PHE A 154
VAL A 152
 None
 1.12A 3rv5C-5mapA:
undetectable
3rv5D-5mapA:
0.5		 3rv5C-5mapA:
14.03
3rv5D-5mapA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5map DTPA
(Streptomyces
lividans) 		4 / 5 LEU A 442
GLY A 439
PHE A 156
PHE A 160
 None
 1.09A 3smtA-5mapA:
undetectable		 3smtA-5mapA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5map DTPA
(Streptomyces
lividans) 		5 / 11 PHE A 390
VAL A 290
GLY A 400
LEU A 177
PHE A 180
 HEM  A 901 (-3.8A)
None
None
None
None
 0.76A 3t3rA-5mapA:
undetectable		 3t3rA-5mapA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5map DTPA
(Streptomyces
lividans) 		5 / 9 PRO A 234
ALA A  96
ALA A 203
ASP A 202
ARG A  97
 None
 1.48A 3ur0C-5mapA:
undetectable		 3ur0C-5mapA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5map DTPA
(Streptomyces
lividans) 		5 / 12 LEU A 117
ALA A 432
PHE A  82
LEU A 210
THR A 124
 None
 1.13A 4iaqA-5mapA:
undetectable		 4iaqA-5mapA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5map DTPA
(Streptomyces
lividans) 		4 / 6 VAL A 289
VAL A 368
TRP A 393
PHE A 268
 None
 1.48A 5addA-5mapA:
undetectable
5addB-5mapA:
undetectable		 5addA-5mapA:
21.19
5addB-5mapA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5map DTPA
(Streptomyces
lividans) 		4 / 6 VAL A 289
VAL A 368
TRP A 393
PHE A 268
 None
 1.46A 5adeA-5mapA:
undetectable
5adeB-5mapA:
undetectable		 5adeA-5mapA:
21.19
5adeB-5mapA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5map DTPA
(Streptomyces
lividans) 		4 / 8 PHE A 390
PRO A 371
LEU A 389
LEU A 388
 HEM  A 901 (-3.8A)
None
None
HEM  A 901 ( 4.1A)
 0.99A 5dzkF-5mapA:
undetectable
5dzkT-5mapA:
undetectable		 5dzkF-5mapA:
22.01
5dzkT-5mapA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5map DTPA
(Streptomyces
lividans) 		5 / 11 ALA A 221
VAL A 101
LEU A 194
LEU A 118
VAL A 196
 None
 1.08A 5eb5A-5mapA:
undetectable		 5eb5A-5mapA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5map DTPA
(Streptomyces
lividans) 		4 / 8 ASN A 231
ARG A 232
THR A 237
GLY A 235
 None
 0.98A 5nzxA-5mapA:
undetectable		 5nzxA-5mapA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5map DTPA
(Streptomyces
lividans) 		3 / 3 GLN A 197
TRP A 195
VAL A 101
 None
 1.15A 6auuA-5mapA:
undetectable		 6auuA-5mapA:
21.60