SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mb9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 THR A 357
GLU A 317
THR A 318
LEU A 249
 None
 1.39A 1d4fC-5mb9A:
undetectable		 1d4fC-5mb9A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 TYR A 134
LEU A  51
ASN A  40
ALA A  64
 None
 1.01A 2bnnA-5mb9A:
undetectable
2bnnB-5mb9A:
undetectable		 2bnnA-5mb9A:
17.70
2bnnB-5mb9A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 327
ILE A 360
GLY A 353
GLY A 352
 None
None
ATP  A 700 (-3.2A)
ATP  A 700 (-3.6A)
 0.90A 2qx4A-5mb9A:
undetectable
2qx4B-5mb9A:
undetectable		 2qx4A-5mb9A:
17.07
2qx4B-5mb9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PRO A 358
PRO A 377
SER A 378
PRO A 386
 None
 0.97A 2v32C-5mb9A:
undetectable
2v32D-5mb9A:
undetectable		 2v32C-5mb9A:
17.77
2v32D-5mb9A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PRO A 358
PRO A 377
SER A 378
PRO A 386
 None
 0.99A 2v41C-5mb9A:
undetectable
2v41D-5mb9A:
undetectable		 2v41C-5mb9A:
17.77
2v41D-5mb9A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PRO A 386
PRO A 358
PRO A 377
SER A 378
 None
 1.00A 2v41G-5mb9A:
undetectable
2v41H-5mb9A:
undetectable		 2v41G-5mb9A:
17.77
2v41H-5mb9A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 GLU A  41
GLU A 144
TYR A  60
ARG A 137
 None
 0.91A 2zt7A-5mb9A:
undetectable		 2zt7A-5mb9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 146
ALA A 395
ALA A 142
VAL A 139
LEU A 169
 None
 1.24A 3b0wB-5mb9A:
undetectable		 3b0wB-5mb9A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 LEU A 375
ASP A 211
VAL A 209
GLY A 393
ILE A 349
 None
MG  A 701 (-3.4A)
None
None
None
 1.00A 3em3B-5mb9A:
undetectable		 3em3B-5mb9A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB800_0
(GLUTAMATE RECEPTOR 2)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 TYR A 316
LEU A 245
ASP A 246
PRO A 386
GLY A 352
 None
None
ATP  A 700 ( 4.2A)
None
ATP  A 700 (-3.6A)
 1.40A 3lsfB-5mb9A:
undetectable
3lsfE-5mb9A:
undetectable		 3lsfB-5mb9A:
17.78
3lsfE-5mb9A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 7 GLY A 213
GLY A 214
SER A 217
LEU A 245
PHE A 327
 ATP  A 700 (-3.5A)
ATP  A 700 (-3.2A)
None
None
None
 1.07A 3o9mA-5mb9A:
undetectable		 3o9mA-5mb9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 ALA A 189
VAL A 154
GLY A  17
ALA A  28
LEU A 192
 None
 0.97A 3sm2B-5mb9A:
undetectable		 3sm2B-5mb9A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 LEU A 375
ASP A 211
VAL A 209
GLY A 393
ILE A 349
 None
MG  A 701 (-3.4A)
None
None
None
 0.97A 4dqhA-5mb9A:
undetectable		 4dqhA-5mb9A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 ALA A 173
LEU A 178
VAL A 150
ILE A  27
ALA A 398
 None
 0.96A 4j14A-5mb9A:
undetectable		 4j14A-5mb9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 TYR A 134
THR A  19
PHE A  20
ILE A  27
 None
 1.12A 4jx1E-5mb9A:
undetectable		 4jx1E-5mb9A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 SER A 289
THR A 354
SER A 387
ASP A 211
GLY A 242
 ATP  A 700 (-2.4A)
ATP  A 700 (-4.3A)
ATP  A 700 ( 4.8A)
MG  A 701 (-3.4A)
ATP  A 700 (-3.5A)
 1.30A 4qb9F-5mb9A:
undetectable		 4qb9F-5mb9A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		7 / 10 GLY A 214
GLY A 242
GLU A 282
LYS A 285
ARG A 286
SER A 289
GLY A 353
 ATP  A 700 (-3.2A)
ATP  A 700 (-3.5A)
ATP  A 700 (-3.5A)
ATP  A 700 (-2.9A)
None
ATP  A 700 (-2.4A)
ATP  A 700 (-3.2A)
 0.80A 5aqfA-5mb9A:
44.4		 5aqfA-5mb9A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		7 / 10 GLY A 214
GLY A 242
GLU A 282
LYS A 285
ARG A 286
SER A 289
GLY A 353
 ATP  A 700 (-3.2A)
ATP  A 700 (-3.5A)
ATP  A 700 (-3.5A)
ATP  A 700 (-2.9A)
None
ATP  A 700 (-2.4A)
ATP  A 700 (-3.2A)
 0.80A 5aqfC-5mb9A:
44.3		 5aqfC-5mb9A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		6 / 10 GLY A 213
GLY A 242
LYS A 285
ARG A 286
SER A 289
GLY A 353
 ATP  A 700 (-3.5A)
ATP  A 700 (-3.5A)
ATP  A 700 (-2.9A)
None
ATP  A 700 (-2.4A)
ATP  A 700 (-3.2A)
 1.11A 5aqyA-5mb9A:
46.7		 5aqyA-5mb9A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		7 / 10 GLY A 214
GLY A 242
GLU A 282
LYS A 285
ARG A 286
SER A 289
GLY A 353
 ATP  A 700 (-3.2A)
ATP  A 700 (-3.5A)
ATP  A 700 (-3.5A)
ATP  A 700 (-2.9A)
None
ATP  A 700 (-2.4A)
ATP  A 700 (-3.2A)
 0.78A 5aqyA-5mb9A:
46.7		 5aqyA-5mb9A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ILE A 481
ILE A 478
HIS A 477
VAL A 526
 None
 0.76A 5jmnA-5mb9A:
undetectable		 5jmnA-5mb9A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 VAL A 180
LEU A 135
THR A 132
ALA A 131
 None
 0.89A 5tt3H-5mb9A:
undetectable		 5tt3H-5mb9A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 PHE A 327
ILE A 360
GLY A 242
LEU A 249
HIS A 252
 None
None
ATP  A 700 (-3.5A)
None
None
 1.40A 5v5zA-5mb9A:
undetectable		 5v5zA-5mb9A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 TYR A 194
TYR A 229
ILE A 207
ALA A 193
LEU A 389
 None
 1.05A 5zwrA-5mb9A:
undetectable		 5zwrA-5mb9A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 TYR A 194
TYR A 229
ILE A 207
ALA A 193
LEU A 389
 None
 1.04A 5zwrB-5mb9A:
undetectable		 5zwrB-5mb9A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 375
ASP A 211
VAL A 209
GLY A 393
ILE A 349
 None
MG  A 701 (-3.4A)
None
None
None
 1.05A 6dgxB-5mb9A:
undetectable		 6dgxB-5mb9A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 375
ASP A 211
VAL A 209
GLY A 393
ILE A 349
 None
MG  A 701 (-3.4A)
None
None
None
 1.02A 6dh6B-5mb9A:
undetectable		 6dh6B-5mb9A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 5mb9 PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 LEU A 277
ASP A 266
PRO A 267
ARG A 268
 None
 1.27A 6fgdA-5mb9A:
undetectable		 6fgdA-5mb9A:
21.94