SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mbg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE
(Beggiatoa
sp.
PS) 		5 / 12 SER A 249
PHE A 154
THR A 293
ILE A 216
SER A 219
 None
None
IOD  A 403 ( 4.9A)
None
None
 1.28A 2fj1A-5mbgA:
undetectable		 2fj1A-5mbgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE
(Beggiatoa
sp.
PS) 		5 / 12 SER A 249
PHE A 154
THR A 293
ILE A 216
SER A 219
 None
None
IOD  A 403 ( 4.9A)
None
None
 1.33A 2o7oA-5mbgA:
undetectable		 2o7oA-5mbgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TCT_A_CTCA222_0
(TETRACYCLINE
REPRESSOR)		 5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE
(Beggiatoa
sp.
PS) 		5 / 12 SER A 249
PHE A 154
THR A 293
ILE A 216
SER A 219
 None
None
IOD  A 403 ( 4.9A)
None
None
 1.36A 2tctA-5mbgA:
undetectable		 2tctA-5mbgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE
(Beggiatoa
sp.
PS) 		5 / 12 SER A 249
PHE A 154
THR A 293
ILE A 216
SER A 219
 None
None
IOD  A 403 ( 4.9A)
None
None
 1.30A 4v2gB-5mbgA:
undetectable		 4v2gB-5mbgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE
(Beggiatoa
sp.
PS) 		5 / 12 LEU A 248
GLU A 150
GLY A 251
ILE A 216
GLY A 295
 None
 1.10A 4yvgA-5mbgA:
undetectable		 4yvgA-5mbgA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE
(Beggiatoa
sp.
PS) 		5 / 10 LEU A 248
SER A 219
LEU A 220
ASP A 221
ILE A 152
 None
 1.28A 6dlzB-5mbgA:
undetectable
6dlzC-5mbgA:
undetectable		 6dlzB-5mbgA:
17.82
6dlzC-5mbgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE
(Beggiatoa
sp.
PS) 		5 / 11 ILE A 152
LEU A 248
SER A 219
LEU A 220
ASP A 221
 None
 1.28A 6dlzA-5mbgA:
undetectable
6dlzD-5mbgA:
undetectable		 6dlzA-5mbgA:
17.82
6dlzD-5mbgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE
(Beggiatoa
sp.
PS) 		5 / 10 LEU A 248
SER A 219
LEU A 220
ASP A 221
ILE A 152
 None
 1.27A 6dm1B-5mbgA:
undetectable
6dm1C-5mbgA:
undetectable		 6dm1B-5mbgA:
17.82
6dm1C-5mbgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE
(Beggiatoa
sp.
PS) 		5 / 11 ILE A 152
LEU A 248
SER A 219
LEU A 220
ASP A 221
 None
 1.27A 6dm1A-5mbgA:
undetectable
6dm1D-5mbgA:
undetectable		 6dm1A-5mbgA:
17.82
6dm1D-5mbgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE
(Beggiatoa
sp.
PS) 		5 / 10 LEU A 248
SER A 219
LEU A 220
ASP A 221
ILE A 152
 None
 1.30A 6dm2B-5mbgA:
undetectable
6dm2C-5mbgA:
undetectable		 6dm2B-5mbgA:
17.82
6dm2C-5mbgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE
(Beggiatoa
sp.
PS) 		5 / 10 ILE A 152
LEU A 248
SER A 219
LEU A 220
ASP A 221
 None
 1.30A 6dm2A-5mbgA:
undetectable
6dm2D-5mbgA:
undetectable		 6dm2A-5mbgA:
17.82
6dm2D-5mbgA:
17.82