SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mc5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		5 / 11 ALA A 425
LEU A 435
LEU A 359
LEU A 338
SER A 350
 None
 1.13A 1h9zA-5mc5A:
undetectable		 1h9zA-5mc5A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_C_COCC302_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 4 GLU A 131
TYR A 128
PRO A  98
ASP A 130
 None
 1.50A 1i7zD-5mc5A:
0.2		 1i7zD-5mc5A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 8 TRP A 326
GLY A 367
TYR A 382
HIS A 370
 None
None
GOL  A 506 ( 4.5A)
MN  A 499 ( 3.6A)
 1.08A 1maaD-5mc5A:
undetectable		 1maaD-5mc5A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 4 ILE A 346
ASP A 419
LEU A 426
ARG A 442
 None
 1.45A 2a7qA-5mc5A:
undetectable		 2a7qA-5mc5A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 6 GLU A 131
TYR A 128
SER A 138
GLN A 139
 None
 1.16A 2cl5B-5mc5A:
undetectable		 2cl5B-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 7 HIS A 377
ASP A 453
THR A 410
HIS A 255
 GLY  A 503 ( 3.9A)
None
MN  A 499 ( 4.0A)
PRO  A 504 (-4.2A)
 1.38A 3abkA-5mc5A:
undetectable
3abkC-5mc5A:
undetectable		 3abkA-5mc5A:
undetectable
3abkC-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 7 HIS A 377
ASP A 453
THR A 410
HIS A 255
 GLY  A 503 ( 3.9A)
None
MN  A 499 ( 4.0A)
PRO  A 504 (-4.2A)
 1.39A 3ag2A-5mc5A:
undetectable
3ag2C-5mc5A:
2.3		 3ag2A-5mc5A:
undetectable
3ag2C-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 7 HIS A 377
ASP A 453
THR A 410
HIS A 255
 GLY  A 503 ( 3.9A)
None
MN  A 499 ( 4.0A)
PRO  A 504 (-4.2A)
 1.40A 3ag4A-5mc5A:
undetectable
3ag4C-5mc5A:
undetectable		 3ag4A-5mc5A:
undetectable
3ag4C-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 5 ARG A 450
ILE A 244
TYR A 241
THR A 242
 PRO  A 504 (-3.7A)
None
GLY  A 503 ( 3.6A)
None
 1.31A 3dgqA-5mc5A:
undetectable		 3dgqA-5mc5A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC201_1
(PROTEIN S100-A4)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		5 / 9 PHE A  23
GLY A  84
CYH A 183
ILE A 180
PHE A 284
 None
 1.27A 3ko0A-5mc5A:
undetectable
3ko0C-5mc5A:
0.3		 3ko0A-5mc5A:
22.64
3ko0C-5mc5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		5 / 10 PHE A  23
GLY A  84
CYH A 183
ILE A 180
PHE A 284
 None
 1.33A 3ko0L-5mc5A:
0.4
3ko0N-5mc5A:
undetectable		 3ko0L-5mc5A:
22.64
3ko0N-5mc5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 6 PHE A 284
CYH A 283
THR A  78
PHE A  23
 None
 1.22A 3ltwA-5mc5A:
undetectable		 3ltwA-5mc5A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		3 / 3 LYS A  92
SER A 138
GLN A 139
 None
 1.37A 3si7A-5mc5A:
undetectable		 3si7A-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 8 PHE A  96
TYR A  83
VAL A  85
ILE A  45
 None
 0.64A 4a97D-5mc5A:
undetectable		 4a97D-5mc5A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 7 PHE A  96
TYR A  83
VAL A  85
ILE A  45
 None
 0.66A 4a97H-5mc5A:
undetectable		 4a97H-5mc5A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 8 PHE A  96
TYR A  83
VAL A  85
ILE A  45
 None
 0.64A 4a97I-5mc5A:
undetectable		 4a97I-5mc5A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		5 / 11 LEU A 274
ILE A 244
SER A 286
LEU A 254
ILE A 451
 None
None
None
PRO  A 504 (-4.5A)
None
 1.20A 4dm8A-5mc5A:
undetectable		 4dm8A-5mc5A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY A 447
ILE A 418
ARG A 265
SER A 251
LEU A 254
 None
None
None
None
PRO  A 504 (-4.5A)
 1.05A 4iv0A-5mc5A:
undetectable		 4iv0A-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		5 / 10 TYR A 382
ASP A 153
PRO A 327
GLY A 381
SER A 396
 GOL  A 506 ( 4.5A)
None
None
None
None
 1.24A 4mmdA-5mc5A:
undetectable		 4mmdA-5mc5A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY A 447
ILE A 418
ARG A 265
SER A 251
LEU A 254
 None
None
None
None
PRO  A 504 (-4.5A)
 1.13A 4mwzA-5mc5A:
undetectable		 4mwzA-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY A 447
ILE A 418
ARG A 265
SER A 251
LEU A 254
 None
None
None
None
PRO  A 504 (-4.5A)
 1.05A 4mwzB-5mc5A:
undetectable		 4mwzB-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 5 ASN A  26
LEU A  25
GLU A 191
THR A 188
 None
 1.23A 4p6sA-5mc5A:
undetectable		 4p6sA-5mc5A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		5 / 11 PHE A 371
VAL A 386
TYR A 382
VAL A 185
GLY A 380
 None
None
GOL  A 506 ( 4.5A)
None
None
 1.26A 4xnxA-5mc5A:
undetectable		 4xnxA-5mc5A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		3 / 3 LEU A 435
ARG A 437
ARG A 444
 None
 0.92A 4yiaB-5mc5A:
undetectable		 4yiaB-5mc5A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 7 VAL A 126
PHE A 117
HIS A 112
GLU A 115
 None
 1.45A 5ad9A-5mc5A:
undetectable
5ad9B-5mc5A:
undetectable		 5ad9A-5mc5A:
12.07
5ad9B-5mc5A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		5 / 12 ASP A 287
HIS A 206
THR A 289
SER A 203
THR A 465
 MN  A 500 ( 2.3A)
None
None
None
None
 1.31A 5hfjB-5mc5A:
undetectable		 5hfjB-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		3 / 3 VAL A 449
TYR A 306
GLN A 302
 None
 0.73A 5qgrA-5mc5A:
undetectable		 5qgrA-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		3 / 3 VAL A 449
TYR A 306
GLN A 302
 None
 0.71A 5qgtA-5mc5A:
undetectable		 5qgtA-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 7 HIS A 377
ASP A 453
THR A 410
HIS A 255
 GLY  A 503 ( 3.9A)
None
MN  A 499 ( 4.0A)
PRO  A 504 (-4.2A)
 1.34A 5x1fN-5mc5A:
undetectable
5x1fP-5mc5A:
1.9		 5x1fN-5mc5A:
undetectable
5x1fP-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 397
THR A 399
ARG A 401
GLY A 323
LEU A 403
 None
 1.10A 6b0lB-5mc5A:
undetectable		 6b0lB-5mc5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS A 366
VAL A 467
ARG A 450
ILE A 288
ASP A 276
 PRO  A 504 (-3.8A)
None
PRO  A 504 (-3.7A)
None
MN  A 500 (-1.9A)
 1.45A 6bxnA-5mc5A:
undetectable		 6bxnA-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 8 ARG A 450
GLU A 412
VAL A 376
ARG A 469
 PRO  A 504 (-3.7A)
MN  A 499 (-2.8A)
None
None
 1.03A 6fbvD-5mc5A:
undetectable		 6fbvD-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 6 HIS A 377
ASP A 453
THR A 410
HIS A 255
 GLY  A 503 ( 3.9A)
None
MN  A 499 ( 4.0A)
PRO  A 504 (-4.2A)
 1.35A 6nknA-5mc5A:
undetectable
6nknC-5mc5A:
2.4		 6nknA-5mc5A:
undetectable
6nknC-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens) 		4 / 7 HIS A 377
ASP A 453
THR A 410
HIS A 255
 GLY  A 503 ( 3.9A)
None
MN  A 499 ( 4.0A)
PRO  A 504 (-4.2A)
 1.34A 6nmpN-5mc5A:
undetectable
6nmpP-5mc5A:
undetectable		 6nmpN-5mc5A:
undetectable
6nmpP-5mc5A:
undetectable