SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		10 / 12 ALA A 167
TYR A 169
TYR A 195
ASP A 197
GLN A 199
GLU A 236
ASP A 238
GLU A 241
ARG A 275
ASP A 403
 None
None
None
None
GOL  A 501 ( 4.6A)
GOL  A 501 (-3.3A)
GOL  A 501 (-2.9A)
GOL  A 501 (-3.5A)
None
None
 0.49A 1dy4A-5mchA:
60.7		 1dy4A-5mchA:
51.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		5 / 12 TYR A 195
ASP A 197
GLN A 199
GLU A 236
ASP A 405
 None
None
GOL  A 501 ( 4.6A)
GOL  A 501 (-3.3A)
None
 1.19A 1dy4A-5mchA:
60.7		 1dy4A-5mchA:
51.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		3 / 3 ALA A  27
VAL A  95
TRP A 100
 None
 0.99A 1gmkC-5mchA:
undetectable
1gmkD-5mchA:
undetectable		 1gmkC-5mchA:
3.08
1gmkD-5mchA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		3 / 3 THR A  85
PRO A  83
THR A  87
 None
 0.66A 209dC-5mchA:
undetectable		 209dC-5mchA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		4 / 7 PHE A 335
GLU A 331
ARG A 342
ILE A 460
 None
 1.48A 2nsiC-5mchA:
undetectable
2nsiD-5mchA:
undetectable		 2nsiC-5mchA:
21.95
2nsiD-5mchA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		4 / 8 ILE A  35
PHE A 151
GLY A 453
MET A 398
 None
 0.94A 2qwxA-5mchA:
undetectable
2qwxB-5mchA:
undetectable		 2qwxA-5mchA:
18.10
2qwxB-5mchA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_A_CTCA1385_0
(TETX2 PROTEIN)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		5 / 10 ASP A 412
PHE A 117
GLY A 128
PRO A 438
GLY A 436
 None
 1.32A 2y6rA-5mchA:
undetectable		 2y6rA-5mchA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		3 / 3 TYR A 182
GLY A 178
ASP A 176
 None
 0.64A 3ou6C-5mchA:
undetectable		 3ou6C-5mchA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		4 / 8 ASP A 238
GLY A 284
GLU A 241
ARG A 275
 GOL  A 501 (-2.9A)
None
GOL  A 501 (-3.5A)
None
 1.04A 3s3nA-5mchA:
undetectable		 3s3nA-5mchA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		3 / 3 GLN A 247
PHE A 297
TYR A 336
 None
 0.84A 3ucjB-5mchA:
undetectable		 3ucjB-5mchA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		3 / 3 GLN A 247
PHE A 297
TYR A 336
 None
 0.90A 3ucjA-5mchA:
undetectable		 3ucjA-5mchA:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		9 / 9 ASN A 165
ALA A 167
TYR A 169
TYR A 195
ASP A 197
GLU A 236
ASP A 238
GLU A 241
TRP A 401
 None
None
None
None
None
GOL  A 501 (-3.3A)
GOL  A 501 (-2.9A)
GOL  A 501 (-3.5A)
None
 0.21A 4ipmA-5mchA:
64.8		 4ipmA-5mchA:
54.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		4 / 6 ASP A 258
ASN A 257
ALA A 235
ASP A 174
 None
 1.19A 4mdbA-5mchA:
undetectable		 4mdbA-5mchA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		4 / 8 ILE A  35
PHE A 151
GLY A 453
MET A 398
 None
 0.94A 4qogA-5mchA:
undetectable
4qogB-5mchA:
undetectable		 4qogA-5mchA:
18.10
4qogB-5mchA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		4 / 5 TYR A 195
SER A 399
ASP A 238
ASP A 286
 None
None
GOL  A 501 (-2.9A)
None
 1.06A 4qtuB-5mchA:
undetectable		 4qtuB-5mchA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		3 / 3 SER A 308
TYR A 298
ASP A 161
 None
 0.86A 4rp8C-5mchA:
undetectable		 4rp8C-5mchA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		4 / 5 GLY A  23
THR A  24
HIS A  61
GLY A  65
 None
 0.58A 4v20A-5mchA:
63.7		 4v20A-5mchA:
56.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		4 / 4 ASP A 274
SER A 272
ASP A 269
HIS A 202
 None
 1.39A 5wyqB-5mchA:
undetectable		 5wyqB-5mchA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		4 / 5 HIS A  61
ALA A  26
GLY A  23
TYR A 191
 None
 1.19A 5yodD-5mchA:
undetectable		 5yodD-5mchA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		3 / 3 MET A 363
ASP A 286
ARG A 334
 None
 1.18A 5z6jA-5mchA:
undetectable		 5z6jA-5mchA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		3 / 3 MET A 363
ASP A 286
ARG A 334
 None
 1.17A 5z6kA-5mchA:
undetectable		 5z6kA-5mchA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		4 / 6 GLN A 145
PHE A 144
LEU A 237
PHE A 332
 None
 1.10A 5zcpC-5mchA:
undetectable
5zcpJ-5mchA:
undetectable		 5zcpC-5mchA:
18.61
5zcpJ-5mchA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		3 / 3 ASP A 376
ASP A 269
ASN A 212
 None
 0.80A 6gngB-5mchA:
undetectable		 6gngB-5mchA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5mch CELLOBIOHYDROLASE
CHBI
(Daphnia
pulex) 		3 / 3 TRP A  59
ILE A  92
ASP A  93
 None
PCA  A  20 ( 4.1A)
None
 0.59A 6i0y7-5mchA:
undetectable		 6i0y7-5mchA:
4.28