SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		3 / 3 ASP A  79
ARG A   5
ILE A  36
 None
 0.77A 1a4gB-5mdhA:
undetectable		 1a4gB-5mdhA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 10 VAL A   6
VAL A   8
ASN A  25
ILE A  15
LEU A  20
 None
None
None
NAD  A 334 (-3.4A)
None
 0.94A 1fe2A-5mdhA:
undetectable		 1fe2A-5mdhA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 GLN A  33
GLY A  24
GLY A  26
LEU A  37
LEU A  64
 None
 0.97A 1rjdA-5mdhA:
4.5		 1rjdA-5mdhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 GLN A  33
GLY A  24
GLY A  26
LEU A  37
LEU A  64
 None
 0.96A 1rjdB-5mdhA:
4.4		 1rjdB-5mdhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 GLN A  33
GLY A  24
GLY A  26
LEU A  37
LEU A  64
 None
 0.97A 1rjdC-5mdhA:
4.2		 1rjdC-5mdhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 11 LEU A 170
GLY A 207
TYR A 209
ILE A 166
VAL A 177
 None
 1.47A 1tmxA-5mdhA:
undetectable		 1tmxA-5mdhA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 11 ASP A 193
GLU A 205
ILE A 166
HIS A 159
ILE A 182
 None
 1.31A 2dg3A-5mdhA:
undetectable		 2dg3A-5mdhA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		4 / 4 LEU A  20
ILE A  84
ILE A 249
ALA A 246
 None
 0.84A 2i30A-5mdhA:
undetectable		 2i30A-5mdhA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 VAL A  82
PHE A  29
ILE A  35
LEU A  64
VAL A  28
 None
 0.97A 2jn3A-5mdhA:
undetectable		 2jn3A-5mdhA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		3 / 3 SER A  27
HIS A 252
ASP A 158
 None
 0.70A 2oxtA-5mdhA:
4.8		 2oxtA-5mdhA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		4 / 6 LEU A 137
THR A 134
PHE A 327
LEU A 330
 None
 1.04A 2wm3A-5mdhA:
4.4		 2wm3A-5mdhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 VAL A  52
LEU A  56
GLY A  10
ALA A  11
LEU A  39
 None
None
NAD  A 334 (-3.2A)
None
None
 1.08A 3n8zA-5mdhA:
1.6		 3n8zA-5mdhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		4 / 8 LEU A  19
VAL A   8
LEU A 157
LEU A 154
 None
None
NAD  A 334 (-4.1A)
NAD  A 334 (-4.1A)
 0.87A 4l1xA-5mdhA:
undetectable		 4l1xA-5mdhA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 11 HIS A 186
VAL A 233
ASN A 130
LEU A 100
ALA A 242
 NAD  A 334 ( 3.7A)
None
MAK  A 335 ( 3.5A)
None
None
 1.37A 4m83A-5mdhA:
undetectable		 4m83A-5mdhA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		3 / 3 SER A 152
MET A 268
ASP A 273
 None
 0.90A 4mm4B-5mdhA:
undetectable		 4mm4B-5mdhA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 LEU A  64
LEU A  53
LEU A  20
ALA A  11
ALA A  69
 None
 1.05A 4x1iD-5mdhA:
undetectable		 4x1iD-5mdhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 LEU A  64
LEU A  53
LEU A  20
ALA A  11
ALA A  69
 None
 1.22A 5eypB-5mdhA:
undetectable		 5eypB-5mdhA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 LEU A  85
ALA A  83
LEU A  80
PHE A  77
LEU A  64
 None
 1.19A 5ljcA-5mdhA:
undetectable		 5ljcA-5mdhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 LEU A  64
LEU A  53
LEU A  20
ALA A  11
ALA A  69
 None
 1.26A 5nm5B-5mdhA:
undetectable		 5nm5B-5mdhA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 PHE A  29
ILE A  35
ALA A  11
ILE A  15
ALA A 246
 None
None
None
NAD  A 334 (-3.4A)
None
 1.11A 5vceA-5mdhA:
undetectable		 5vceA-5mdhA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 LEU A  64
LEU A  53
LEU A  20
ALA A  11
ALA A  69
 None
 1.18A 5xiwD-5mdhA:
undetectable		 5xiwD-5mdhA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5mdh MALATE DEHYDROGENASE
(Sus
scrofa) 		5 / 12 SER A 152
VAL A  86
GLY A 129
ALA A 132
VAL A 253
 None
NAD  A 334 (-4.5A)
NAD  A 334 (-3.6A)
NAD  A 334 ( 4.4A)
None
 0.91A 6bqgA-5mdhA:
undetectable		 6bqgA-5mdhA:
14.20