SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mdn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		3 / 3 VAL A 133
VAL A 150
TRP A 152
 None
 0.90A 1av2C-5mdnA:
undetectable
1av2D-5mdnA:
undetectable		 1av2C-5mdnA:
1.80
1av2D-5mdnA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_1
(GLUCOAMYLASE-471)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 12 ARG A 118
ASP A 122
TYR A 109
GLU A 110
TRP A 376
 None
 1.50A 1gahA-5mdnA:
undetectable		 1gahA-5mdnA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 8 SER A 422
SER A 563
ASP A 590
LYS A 591
 None
 1.26A 1hwiB-5mdnA:
3.1		 1hwiB-5mdnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 7 LEU A 341
SER A 339
LEU A 343
ALA A 297
 None
 0.86A 1j8uA-5mdnA:
undetectable		 1j8uA-5mdnA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 4 VAL A 457
ALA A 454
LEU A 434
PHE A 461
 None
 1.16A 1q97B-5mdnA:
undetectable		 1q97B-5mdnA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		3 / 3 VAL A 133
VAL A 150
TRP A 152
 None
 0.85A 1w5uC-5mdnA:
undetectable
1w5uD-5mdnA:
undetectable		 1w5uC-5mdnA:
1.80
1w5uD-5mdnA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		3 / 3 VAL A 150
TRP A 152
VAL A 133
 None
 0.82A 2izqA-5mdnA:
undetectable
2izqB-5mdnA:
undetectable		 2izqA-5mdnA:
1.80
2izqB-5mdnA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		3 / 3 TRP A 237
ALA A 274
VAL A 270
 None
 0.76A 2izqA-5mdnA:
undetectable
2izqB-5mdnA:
undetectable		 2izqA-5mdnA:
1.80
2izqB-5mdnA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		3 / 3 TYR A 230
VAL A 282
THR A 292
 None
 0.82A 2ygnA-5mdnA:
undetectable		 2ygnA-5mdnA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 12 GLY A 214
ILE A 227
LEU A 166
LEU A 240
LEU A 251
 None
 1.26A 3cs8A-5mdnA:
undetectable		 3cs8A-5mdnA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 5 ARG A 164
ARG A  29
GLY A  28
GLU A  27
 None
 1.14A 3k9fA-5mdnA:
undetectable
3k9fB-5mdnA:
undetectable
3k9fC-5mdnA:
undetectable		 3k9fA-5mdnA:
21.43
3k9fB-5mdnA:
21.43
3k9fC-5mdnA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 6 ARG A 164
ARG A  29
GLY A  28
GLU A  27
 None
 1.14A 3k9fA-5mdnA:
undetectable
3k9fB-5mdnA:
undetectable
3k9fD-5mdnA:
undetectable		 3k9fA-5mdnA:
21.43
3k9fB-5mdnA:
21.43
3k9fD-5mdnA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 5 ASN A 280
ALA A 367
ALA A 366
ARG A 373
 None
 1.48A 3kp2B-5mdnA:
undetectable		 3kp2B-5mdnA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 10 THR A 599
GLY A 411
LEU A 597
LEU A 412
ILE A 641
 None
 1.21A 3kvrA-5mdnA:
undetectable		 3kvrA-5mdnA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 10 THR A 599
GLY A 411
LEU A 597
LEU A 412
ILE A 641
 None
 1.24A 3kvrB-5mdnA:
undetectable		 3kvrB-5mdnA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		3 / 3 ALA A 274
VAL A 270
TRP A 237
 None
 0.76A 3l8lA-5mdnA:
undetectable
3l8lB-5mdnA:
undetectable		 3l8lA-5mdnA:
1.80
3l8lB-5mdnA:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		3 / 3 ALA A 274
VAL A 270
TRP A 237
 None
 0.85A 3l8lC-5mdnA:
undetectable
3l8lD-5mdnA:
undetectable		 3l8lC-5mdnA:
1.80
3l8lD-5mdnA:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		3 / 3 VAL A 133
VAL A 150
TRP A 152
 None
 0.85A 3l8lC-5mdnA:
undetectable
3l8lD-5mdnA:
undetectable		 3l8lC-5mdnA:
1.80
3l8lD-5mdnA:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 12 GLY A  23
VAL A 270
ASP A 254
ASP A 225
PRO A 224
 None
 0.95A 3m6vA-5mdnA:
undetectable		 3m6vA-5mdnA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 9 THR A 599
GLY A 411
LEU A 597
LEU A 412
ILE A 641
 None
 1.20A 3nbqA-5mdnA:
undetectable		 3nbqA-5mdnA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 9 THR A 599
GLY A 411
LEU A 597
LEU A 412
ILE A 641
 None
 1.24A 3nbqD-5mdnA:
undetectable		 3nbqD-5mdnA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 12 ALA A 344
THR A 340
ILE A 281
ALA A 366
VAL A 276
 None
 1.11A 3nvkI-5mdnA:
undetectable		 3nvkI-5mdnA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A 351
ALA A 506
VAL A 357
VAL A 365
LEU A 354
 None
 1.15A 3ogpB-5mdnA:
undetectable		 3ogpB-5mdnA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 11 VAL A 534
ALA A 531
TYR A 439
ALA A 523
TYR A 517
 None
 1.27A 3qxyB-5mdnA:
undetectable
3qxyQ-5mdnA:
undetectable		 3qxyB-5mdnA:
20.86
3qxyQ-5mdnA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 11 VAL A 534
ALA A 531
TYR A 439
ALA A 523
TYR A 517
 None
 1.24A 3rc0A-5mdnA:
undetectable		 3rc0A-5mdnA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 12 ALA A  54
ILE A  80
ALA A  44
VAL A  69
VAL A  70
 None
 1.06A 3rukB-5mdnA:
undetectable		 3rukB-5mdnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UB9_A_NHYA301_1
(CHEMORECEPTOR TLPB)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 10 VAL A 418
ASP A 590
TYR A 593
TYR A 605
LYS A 603
 None
 1.36A 3ub9A-5mdnA:
0.0		 3ub9A-5mdnA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UB9_B_NHYB301_1
(CHEMORECEPTOR TLPB)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 10 VAL A 418
ASP A 590
TYR A 593
TYR A 605
LYS A 603
 None
 1.36A 3ub9B-5mdnA:
0.0		 3ub9B-5mdnA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 12 ILE A 752
ALA A 754
ALA A 755
ALA A 630
LEU A 762
 None
 1.22A 3uvvB-5mdnA:
undetectable		 3uvvB-5mdnA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		3 / 3 TRP A 268
VAL A 276
TRP A 237
 None
 1.24A 3zq8C-5mdnA:
undetectable
3zq8D-5mdnA:
undetectable		 3zq8C-5mdnA:
1.80
3zq8D-5mdnA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		3 / 3 TYR A 558
ASP A 562
ASP A 590
 None
 0.81A 4a6eA-5mdnA:
undetectable		 4a6eA-5mdnA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 6 ARG A 305
ASP A 671
GLU A 318
LEU A 310
 None
 1.27A 4ax8A-5mdnA:
undetectable		 4ax8A-5mdnA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 6 GLU A 171
ASP A 336
ASP A 335
ARG A 308
 MG  A 803 (-4.3A)
None
None
None
 1.37A 4kcnA-5mdnA:
undetectable		 4kcnA-5mdnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 6 GLU A 393
ARG A 392
ASP A 112
ARG A  96
 None
 1.02A 4kcnA-5mdnA:
undetectable		 4kcnA-5mdnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 6 GLU A 171
ASP A 336
ASP A 335
ARG A 308
 MG  A 803 (-4.3A)
None
None
None
 1.39A 4kcnB-5mdnA:
undetectable		 4kcnB-5mdnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 6 GLU A 393
ARG A 392
ASP A 112
ARG A  96
 None
 1.05A 4kcnB-5mdnA:
undetectable		 4kcnB-5mdnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 12 ALA A  54
ILE A  80
ALA A  44
VAL A  69
VAL A  70
 None
 1.08A 4nkvA-5mdnA:
undetectable		 4nkvA-5mdnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 12 ALA A  54
ILE A  80
ALA A  44
VAL A  69
VAL A  70
 None
 1.06A 4nkvC-5mdnA:
undetectable		 4nkvC-5mdnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 12 ALA A  54
ILE A  80
ALA A  44
VAL A  69
VAL A  70
 None
 1.07A 4nkvD-5mdnA:
undetectable		 4nkvD-5mdnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 5 HIS A 459
VAL A 530
GLU A 532
VAL A 457
 None
 1.43A 4p6vB-5mdnA:
undetectable
4p6vE-5mdnA:
undetectable		 4p6vB-5mdnA:
18.62
4p6vE-5mdnA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		3 / 3 VAL A 105
PHE A  42
ARG A  96
 None
 0.92A 4xr4B-5mdnA:
undetectable		 4xr4B-5mdnA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		6 / 12 LEU A 608
VAL A 638
ILE A 758
ALA A 755
GLY A 607
ILE A 614
 None
 1.28A 5j2tC-5mdnA:
undetectable		 5j2tC-5mdnA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 10 LEU A   6
PRO A   5
GLY A 272
LEU A 362
ALA A 274
 None
 1.13A 5o96E-5mdnA:
undetectable
5o96F-5mdnA:
undetectable		 5o96E-5mdnA:
14.25
5o96F-5mdnA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 6 LEU A 564
SER A 563
PHE A 421
ASP A 420
 None
 1.18A 5om3A-5mdnA:
undetectable
5om3B-5mdnA:
undetectable		 5om3A-5mdnA:
6.00
5om3B-5mdnA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		4 / 5 THR A 340
ASP A 236
GLU A 171
ASN A 174
 None
MG  A 802 ( 3.7A)
MG  A 803 (-4.3A)
None
 1.25A 5ybbA-5mdnA:
2.9		 5ybbA-5mdnA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 12 GLY A 723
VAL A 735
ARG A 728
VAL A 719
ASP A 742
 None
 1.29A 6bxlB-5mdnA:
undetectable		 6bxlB-5mdnA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 9 VAL A 228
LEU A 293
GLY A 342
LEU A 343
VAL A 337
 None
 1.31A 6czmB-5mdnA:
undetectable
6czmC-5mdnA:
undetectable		 6czmB-5mdnA:
19.70
6czmC-5mdnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 9 VAL A 228
LEU A 293
GLY A 342
LEU A 343
VAL A 337
 None
 1.31A 6czmD-5mdnA:
2.9
6czmE-5mdnA:
undetectable		 6czmD-5mdnA:
19.70
6czmE-5mdnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5mdn DNA POLYMERASE
(Pyrobaculum
calidifontis) 		5 / 10 VAL A 228
LEU A 293
GLY A 342
LEU A 343
VAL A 337
 None
 1.29A 6czmE-5mdnA:
2.4
6czmF-5mdnA:
4.8		 6czmE-5mdnA:
19.70
6czmF-5mdnA:
19.70