SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mdx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5mdx OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 8 ASP A  59
ASP A  61
TYR O 236
ARG O 237
 None
 1.22A 1ceaA-5mdxA:
undetectable
1ceaB-5mdxA:
undetectable		 1ceaA-5mdxA:
12.46
1ceaB-5mdxA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 5mdx OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 7 ASP A  59
ASP A  61
TYR O 236
ARG O 237
 None
 1.09A 1ceaB-5mdxA:
undetectable		 1ceaB-5mdxA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 5mdx OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 7 ASP A  59
ASP A  61
TYR O 236
ARG O 237
 None
 1.08A 1cebA-5mdxA:
undetectable		 1cebA-5mdxA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 5mdx OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 7 ASP A  59
ASP A  61
TYR O 236
ARG O 237
 None
 1.08A 1cebB-5mdxA:
undetectable		 1cebB-5mdxA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR C 297
LEU C  95
VAL C 185
VAL C 176
LEU C 202
 CLA  C 503 ( 4.7A)
CLA  C 503 (-4.1A)
None
None
None
 1.22A 1rk3A-5mdxC:
undetectable		 1rk3A-5mdxC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 PHE G  92
TYR G  69
LEU G  70
GLY G  76
 CLA  G 602 (-4.5A)
None
CLA  G 602 (-4.1A)
CLA  G 602 (-4.8A)
 0.93A 1rmtC-5mdxG:
undetectable		 1rmtC-5mdxG:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 LEU C 437
ALA C 278
LEU C 276
SER C 273
 CLA  C 501 ( 4.6A)
CLA  C 507 ( 3.7A)
CLA  C 508 (-4.9A)
CLA  C 505 ( 4.2A)
 1.14A 1tt6B-5mdxC:
undetectable		 1tt6B-5mdxC:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		3 / 3 ARG C 370
TYR O 102
LYS O 106
 None
 0.81A 1uujB-5mdxC:
undetectable		 1uujB-5mdxC:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR C 297
LEU C  95
VAL C 185
VAL C 176
LEU C 202
 CLA  C 503 ( 4.7A)
CLA  C 503 (-4.1A)
None
None
None
 1.30A 2hc4A-5mdxC:
undetectable		 2hc4A-5mdxC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 8 ILE A 163
PHE A 168
LEU A  91
PHE C 218
 None
 0.68A 2vdbA-5mdxA:
undetectable		 2vdbA-5mdxA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		3 / 3 TYR O 102
GLU C 367
ASN C 294
 None
 0.92A 2y7hC-5mdxO:
undetectable		 2y7hC-5mdxO:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 SER 4 232
ARG 4 233
PRO 4  78
GLY 4  79
 None
CLA  4 302 (-3.3A)
None
CLA  4 302 (-4.4A)
 1.46A 2y7kB-5mdx4:
undetectable		 2y7kB-5mdx4:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR C 297
LEU C  95
VAL C 185
VAL C 176
LEU C 202
 CLA  C 503 ( 4.7A)
CLA  C 503 (-4.1A)
None
None
None
 1.25A 2zlcA-5mdxC:
undetectable		 2zlcA-5mdxC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 8 GLY A  90
CYH C 287
PHE C 289
PHE C 292
 None
None
CLA  C 503 (-3.5A)
None
 1.06A 3ko0D-5mdxA:
0.1
3ko0E-5mdxA:
undetectable		 3ko0D-5mdxA:
16.93
3ko0E-5mdxA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 8 PHE C 292
GLY A  90
CYH C 287
PHE C 289
 None
None
None
CLA  C 503 (-3.5A)
 1.03A 3ko0B-5mdxC:
undetectable
3ko0J-5mdxC:
undetectable		 3ko0B-5mdxC:
12.11
3ko0J-5mdxC:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 7 PHE C 292
GLY A  90
CYH C 287
PHE C 289
 None
None
None
CLA  C 503 (-3.5A)
 1.03A 3ko0K-5mdxC:
undetectable
3ko0S-5mdxC:
undetectable		 3ko0K-5mdxC:
12.11
3ko0S-5mdxC:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLY G 237
TRP G 131
VAL G 130
 None
 0.71A 3n62B-5mdxG:
undetectable		 3n62B-5mdxG:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLY G 237
TRP G 131
VAL G 130
 None
 0.70A 3n65B-5mdxG:
undetectable		 3n65B-5mdxG:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLY G 237
TRP G 131
VAL G 130
 None
 0.71A 3n66B-5mdxG:
undetectable		 3n66B-5mdxG:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 5mdx OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 PHE O 227
PHE O 124
ASN O 187
LEU O 331
 None
 0.96A 3t3sC-5mdxO:
undetectable		 3t3sC-5mdxO:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 5 SER A 177
ILE A  83
GLY A 175
PRO A 173
 None
 0.94A 3uboB-5mdxA:
undetectable		 3uboB-5mdxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR C 297
LEU C  95
VAL C 185
VAL C 176
LEU C 202
 CLA  C 503 ( 4.7A)
CLA  C 503 (-4.1A)
None
None
None
 1.21A 3vt3A-5mdxC:
undetectable		 3vt3A-5mdxC:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR C 297
LEU C  95
VAL C 185
VAL C 176
LEU C 202
 CLA  C 503 ( 4.7A)
CLA  C 503 (-4.1A)
None
None
None
 1.23A 3vt7A-5mdxC:
undetectable		 3vt7A-5mdxC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 PHE C 315
PHE C 351
ALA C 363
LEU C 375
 None
 0.97A 4ejgA-5mdxC:
undetectable		 4ejgA-5mdxC:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 GLY C 353
GLY C 352
MET C 342
GLU C 354
 None
 1.23A 4fglC-5mdxC:
undetectable		 4fglC-5mdxC:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5mdx PHOTOSYSTEM II
PROTEIN D1
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		5 / 12 PHE C 435
PHE A 206
GLY A 201
LEU A 288
ALA A 156
 None
CLA  A 402 (-4.4A)
CLA  A 402 ( 4.4A)
None
None
 1.03A 4krhB-5mdxC:
undetectable		 4krhB-5mdxC:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 5mdx OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		5 / 10 TYR O 196
VAL C 328
GLY C 338
GLY O 193
ASP C 321
 None
 1.24A 4mmcA-5mdxO:
undetectable		 4mmcA-5mdxO:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 4 ALA A 149
ALA A 152
ALA A 153
ALA A 156
 PHO  A 404 ( 3.8A)
None
CLA  A 402 ( 3.7A)
None
 0.00A 4oadA-5mdxA:
undetectable		 4oadA-5mdxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 4 ALA A 149
ALA A 152
ALA A 153
ALA A 156
 PHO  A 404 ( 3.8A)
None
CLA  A 402 ( 3.7A)
None
 0.00A 4oaeA-5mdxA:
undetectable		 4oaeA-5mdxA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5mdx PHOTOSYSTEM II
PROTEIN D1
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		5 / 12 ALA A 336
GLY C 353
ILE A  89
GLY A  62
GLU A  65
 None
 1.12A 4r29D-5mdxA:
undetectable		 4r29D-5mdxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 GLY G 194
TYR G 191
GLU G 187
ASP G 197
 None
CLA  G 610 (-4.3A)
None
CLA  G 610 (-3.3A)
 1.24A 4xueA-5mdxG:
undetectable		 4xueA-5mdxG:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		5 / 11 LEU A 117
VAL A 116
LEU A  91
GLY A 171
LEU A 159
 CLA  A 405 ( 4.7A)
None
None
None
None
 1.30A 4zbqA-5mdxA:
undetectable		 4zbqA-5mdxA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 5 ALA A 153
HIS A 332
PRO A 162
PHE A 186
 CLA  A 402 ( 3.7A)
None
None
CLA  A 402 (-4.4A)
 1.35A 4ze2A-5mdxA:
undetectable		 4ze2A-5mdxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 6 ALA A 153
THR A 155
VAL A 157
VAL A 123
 CLA  A 402 ( 3.7A)
None
None
PHO  A 404 ( 4.7A)
 1.04A 5eckA-5mdxA:
undetectable		 5eckA-5mdxA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 6 ALA A 153
THR A 155
VAL A 157
VAL A 123
 CLA  A 402 ( 3.7A)
None
None
PHO  A 404 ( 4.7A)
 1.02A 5eckD-5mdxA:
undetectable		 5eckD-5mdxA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 TYR C 395
GLY C 102
GLU C 300
ASP C 187
 None
 1.33A 5emlA-5mdxC:
undetectable		 5emlA-5mdxC:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		5 / 10 ILE A  77
GLY A  69
PHE A  52
SER A 177
GLY A 175
 None
 1.21A 5i6xA-5mdxA:
2.2		 5i6xA-5mdxA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN
CP26, CHLOROPLASTIC
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 TYR C 131
GLY C 136
GLY S  87
LEU S  76
 CLA  S 301 (-4.0A)
None
None
None
 0.88A 5jlcA-5mdxC:
undetectable		 5jlcA-5mdxC:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		5 / 12 GLY A  90
PHE C 218
VAL A 116
PHE A 182
GLY A 164
 None
 0.94A 5koxA-5mdxA:
undetectable		 5koxA-5mdxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5mdx PHOTOSYSTEM II
PROTEIN D1
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		4 / 5 ILE A 283
PHE C 435
SER A 148
ALA A 153
 PHO  A 404 (-4.1A)
None
None
CLA  A 402 ( 3.7A)
 1.20A 5msdA-5mdxA:
undetectable		 5msdA-5mdxA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5mdx PHOTOSYSTEM II
PROTEIN D1
PHOTOSYSTEM II
REACTION CENTER
PROTEIN I
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		4 / 8 HIS A 118
PHE A  93
PRO A  95
TYR I   9
 CLA  A 405 (-3.5A)
CLA  A 405 (-3.9A)
CLA  A 405 (-3.9A)
None
 1.33A 5v4vA-5mdxA:
undetectable		 5v4vA-5mdxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5mdx PHOTOSYSTEM II
PROTEIN D1
PHOTOSYSTEM II
REACTION CENTER
PROTEIN I
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		4 / 8 HIS A 118
PHE A  93
PRO A  95
TYR I   9
 CLA  A 405 (-3.5A)
CLA  A 405 (-3.9A)
CLA  A 405 (-3.9A)
None
 1.31A 5v4vB-5mdxA:
undetectable		 5v4vB-5mdxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5mdx OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		3 / 3 ARG O 166
ARG A  64
ARG C 343
 None
 0.91A 5vcgA-5mdxO:
undetectable		 5vcgA-5mdxO:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		4 / 8 GLY C 371
GLN O 330
TYR O 328
ASP C 383
 None
 1.02A 5vlmB-5mdxC:
2.1		 5vlmB-5mdxC:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		4 / 7 GLY C 371
GLN O 330
TYR O 328
ASP C 383
 None
 1.03A 5vlmE-5mdxC:
undetectable		 5vlmE-5mdxC:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLY G 237
TRP G 131
VAL G 130
 None
 0.70A 5vuoB-5mdxG:
undetectable		 5vuoB-5mdxG:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 GLY C 303
THR C 305
GLU C 308
 None
 0.59A 6b58A-5mdxC:
2.5		 6b58A-5mdxC:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 TYR C 111
PRO C  90
LEU C  86
 None
 0.92A 6beoA-5mdxC:
undetectable		 6beoA-5mdxC:
2.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN
CP26, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 LEU S 220
GLN S 217
LYS S  61
 None
 0.96A 6exiB-5mdxS:
undetectable		 6exiB-5mdxS:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN
CP26, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 LEU S 220
GLN S 217
LYS S  61
 None
 0.94A 6exiA-5mdxS:
undetectable		 6exiA-5mdxS:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU 4  77
ASP 4  84
LEU 4  88
GLY 4  89
PHE 4  94
 CLA  4 302 (-4.1A)
CLA  4 302 (-3.6A)
None
CLA  4 302 ( 4.7A)
None
 1.31A 6r2eG-5mdx4:
undetectable		 6r2eG-5mdx4:
21.43