SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5me4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB
(Pseudomonas
stutzeri) 		5 / 12 TRP A  68
TYR A  44
ASP A  38
SER A  48
ILE A  46
 None
 1.38A 3b7pC-5me4A:
undetectable		 3b7pC-5me4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB
(Pseudomonas
stutzeri) 		5 / 10 ILE A 208
VAL A  66
TYR A  35
ILE A 225
ILE A 222
 None
 1.15A 3p4wD-5me4A:
undetectable		 3p4wD-5me4A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB
(Pseudomonas
stutzeri) 		5 / 10 ILE A 208
VAL A  66
TYR A  35
ILE A 225
ILE A 222
 None
 1.16A 3p4wE-5me4A:
undetectable		 3p4wE-5me4A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB
(Pseudomonas
stutzeri) 		4 / 8 PHE A 139
GLU A 154
TYR A 152
LEU A 121
 None
 1.07A 3rqwC-5me4A:
undetectable
3rqwD-5me4A:
undetectable		 3rqwC-5me4A:
22.90
3rqwD-5me4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB
(Pseudomonas
stutzeri) 		4 / 8 PHE A 139
GLU A 154
TYR A 152
LEU A 121
 None
 1.06A 3rqwI-5me4A:
undetectable
3rqwJ-5me4A:
undetectable		 3rqwI-5me4A:
22.90
3rqwJ-5me4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB
(Pseudomonas
stutzeri) 		4 / 8 GLU A 154
TYR A 152
LEU A 121
PHE A 139
 None
 1.05A 3rqwF-5me4A:
undetectable
3rqwJ-5me4A:
undetectable		 3rqwF-5me4A:
22.90
3rqwJ-5me4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB
(Pseudomonas
stutzeri) 		5 / 10 VAL A  89
PHE A 243
THR A  25
ILE A  15
PHE A  33
 None
 1.23A 3t3qA-5me4A:
undetectable		 3t3qA-5me4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB
(Pseudomonas
stutzeri) 		5 / 9 GLY A 131
PHE A 158
ASN A 161
GLY A 127
ASP A 125
 None
 1.09A 3ztvA-5me4A:
undetectable		 3ztvA-5me4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB
(Pseudomonas
stutzeri) 		5 / 12 LEU A  40
ILE A 208
VAL A  66
ALA A 217
ARG A 221
 None
 1.15A 4a6dA-5me4A:
undetectable		 4a6dA-5me4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB
(Pseudomonas
stutzeri) 		3 / 3 ARG A 178
GLU A  28
TYR A  91
 HP4  A 301 ( 4.0A)
None
None
 0.96A 4r29D-5me4A:
undetectable		 4r29D-5me4A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB
(Pseudomonas
stutzeri) 		5 / 12 ILE A 254
GLU A 255
ARG A 259
ASN A 128
LEU A 261
 None
None
None
HP4  A 301 (-3.1A)
None
 1.49A 5fhzD-5me4A:
undetectable		 5fhzD-5me4A:
20.49