SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5me5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I00_A_D16A315_1 (THYMIDYLATE SYNTHASE)	5me5	EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E (Cucumis melo)	5 / 9	ILE A 186 TRP A 139 ASP A 168 GLY A 167 PHE A 164	None	1.40A	1i00A-5me5A: undetectable	1i00A-5me5A: 19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QEL_D_QELD2_1 (NMDA GLUTAMATE RECEPTOR SUBUNIT GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-2)	5me5	EIF4G EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E (Cucumis melo)	4 / 5	TYR A 154 THR A 155 PHE A 207 LEU B1064	None	1.47A	3qelC-5me5A: undetectable	3qelC-5me5A: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NWW_A_ACAA18_2 (SCRFP-TAG,GP41)	5me5	EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E (Cucumis melo)	3 / 3	LYS A 138 TRP A 139 SER A 185	None	1.30A	5nwwA-5me5A: undetectable	5nwwA-5me5A: 10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VEU_H_RITH602_2 (CYTOCHROME P450 3A5)	5me5	EIF4G EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E (Cucumis melo)	4 / 5	PHE B1067 PHE A 98 LEU B1064 LEU B1072	None	1.10A	5veuH-5me5B: undetectable	5veuH-5me5B: 11.48

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1I00_A_D16A315_1","THYMIDYLATE SYNTHASE","5me5","EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E","Cucumis melo",5,"ILE A 186;TRP A 139;ASP A 168;GLY A 167;PHE A 164","None","1.40A","1i00A-5me5A:undetectable","1i00A-5me5A:19.54"],["3QEL_D_QELD2_1","NMDA GLUTAMATE RECEPTOR SUBUNIT;GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-2","5me5","EIF4G;EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E","Cucumis melo",4,"TYR A 154;THR A 155;PHE A 207;LEU B1064","None","1.47A","3qelC-5me5A:undetectable","3qelC-5me5A:21.05"],["5NWW_A_ACAA18_2","SCRFP-TAG,GP41","5me5","EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E","Cucumis melo",3,"LYS A 138;TRP A 139;SER A 185","None","1.30A","5nwwA-5me5A:undetectable","5nwwA-5me5A:10.33"],["5VEU_H_RITH602_2","CYTOCHROME P450 3A5","5me5","EIF4G;EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E","Cucumis melo",4,"PHE B1067;PHE A  98;LEU B1064;LEU B1072","None","1.10A","5veuH-5me5B:undetectable","5veuH-5me5B:11.48"]]