SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5me6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WQW_A_GCSA502_1 (CHITINASE)	5me6	EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E (Cucumis melo)	4 / 5	GLY A 172 TRP A 187 ALA A 173 PHE A 216	GLY A 172 ( 0.0A) TRP A 187 (-0.5A) ALA A 173 ( 0.0A) PHE A 216 ( 1.3A)	1.26A	3wqwA-5me6A: undetectable	3wqwA-5me6A: 19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IQQ_B_D16B402_1 (THYMIDYLATE SYNTHASE)	5me6	EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E (Cucumis melo)	4 / 7	ILE A 186 ASP A 168 GLY A 167 PHE A 164	ILE A 186 ( 0.7A) ASP A 168 ( 0.6A) GLY A 167 ( 0.0A) PHE A 164 ( 1.3A)	0.88A	4iqqB-5me6A: undetectable	4iqqB-5me6A: 19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NOO_A_D16A402_1 (THYMIDYLATE SYNTHASE)	5me6	EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E (Cucumis melo)	4 / 7	ILE A 186 ASP A 168 GLY A 167 PHE A 164	ILE A 186 ( 0.7A) ASP A 168 ( 0.6A) GLY A 167 ( 0.0A) PHE A 164 ( 1.3A)	0.87A	5nooA-5me6A: undetectable	5nooA-5me6A: 19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NOO_B_D16B402_1 (THYMIDYLATE SYNTHASE)	5me6	EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E (Cucumis melo)	4 / 7	ILE A 186 ASP A 168 GLY A 167 PHE A 164	ILE A 186 ( 0.7A) ASP A 168 ( 0.6A) GLY A 167 ( 0.0A) PHE A 164 ( 1.3A)	0.88A	5nooB-5me6A: undetectable	5nooB-5me6A: 19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NWW_A_ACAA18_2 (SCRFP-TAG,GP41)	5me6	EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E (Cucumis melo)	3 / 3	LYS A 138 TRP A 139 SER A 185	LYS A 138 ( 0.0A) TRP A 139 ( 0.5A) SER A 185 ( 0.0A)	1.13A	5nwwA-5me6A: undetectable	5nwwA-5me6A: 9.34

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3WQW_A_GCSA502_1","CHITINASE","5me6","EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E","Cucumis melo",4,"GLY A 172;TRP A 187;ALA A 173;PHE A 216","GLY A 172 ( 0.0A);TRP A 187 (-0.5A);ALA A 173 ( 0.0A);PHE A 216 ( 1.3A)","1.26A","3wqwA-5me6A:undetectable","3wqwA-5me6A:19.58"],["4IQQ_B_D16B402_1","THYMIDYLATE SYNTHASE","5me6","EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E","Cucumis melo",4,"ILE A 186;ASP A 168;GLY A 167;PHE A 164","ILE A 186 ( 0.7A);ASP A 168 ( 0.6A);GLY A 167 ( 0.0A);PHE A 164 ( 1.3A)","0.88A","4iqqB-5me6A:undetectable","4iqqB-5me6A:19.18"],["5NOO_A_D16A402_1","THYMIDYLATE SYNTHASE","5me6","EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E","Cucumis melo",4,"ILE A 186;ASP A 168;GLY A 167;PHE A 164","ILE A 186 ( 0.7A);ASP A 168 ( 0.6A);GLY A 167 ( 0.0A);PHE A 164 ( 1.3A)","0.87A","5nooA-5me6A:undetectable","5nooA-5me6A:19.18"],["5NOO_B_D16B402_1","THYMIDYLATE SYNTHASE","5me6","EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E","Cucumis melo",4,"ILE A 186;ASP A 168;GLY A 167;PHE A 164","ILE A 186 ( 0.7A);ASP A 168 ( 0.6A);GLY A 167 ( 0.0A);PHE A 164 ( 1.3A)","0.88A","5nooB-5me6A:undetectable","5nooB-5me6A:19.18"],["5NWW_A_ACAA18_2","SCRFP-TAG,GP41","5me6","EUKARYOTIC TRANSCRIPTION INITIATION FACTOR 4E","Cucumis melo",3,"LYS A 138;TRP A 139;SER A 185","LYS A 138 ( 0.0A);TRP A 139 ( 0.5A);SER A 185 ( 0.0A)","1.13A","5nwwA-5me6A:undetectable","5nwwA-5me6A:9.34"]]