SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 238
ILE A 270
GLY A 276
HIS A 281
 SO4  A 501 ( 2.4A)
SO4  A 501 ( 4.2A)
SO4  A 501 ( 4.1A)
SO4  A 501 (-4.0A)
 0.99A 1wmqB-5meaA:
1.3		 1wmqB-5meaA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 238
ILE A 270
GLY A 276
HIS A 281
 SO4  A 501 ( 2.4A)
SO4  A 501 ( 4.2A)
SO4  A 501 ( 4.1A)
SO4  A 501 (-4.0A)
 0.99A 1wpuA-5meaA:
1.3		 1wpuA-5meaA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 238
ILE A 270
GLY A 276
HIS A 281
 SO4  A 501 ( 2.4A)
SO4  A 501 ( 4.2A)
SO4  A 501 ( 4.1A)
SO4  A 501 (-4.0A)
 1.00A 1wpuB-5meaA:
undetectable		 1wpuB-5meaA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 238
ILE A 270
GLY A 276
HIS A 281
 SO4  A 501 ( 2.4A)
SO4  A 501 ( 4.2A)
SO4  A 501 ( 4.1A)
SO4  A 501 (-4.0A)
 0.97A 1wrqA-5meaA:
1.3		 1wrqA-5meaA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 238
ILE A 270
GLY A 276
HIS A 281
 SO4  A 501 ( 2.4A)
SO4  A 501 ( 4.2A)
SO4  A 501 ( 4.1A)
SO4  A 501 (-4.0A)
 0.99A 1wrqB-5meaA:
1.3		 1wrqB-5meaA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 327
LEU A 343
MET A 350
 None
 0.78A 1ya3B-5meaA:
undetectable		 1ya3B-5meaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 371
LEU A 363
THR A 323
MET A 351
LEU A 340
 None
 1.37A 2ft9A-5meaA:
1.5		 2ft9A-5meaA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 399
LEU A 340
ASP A 358
GLU A 322
 None
 1.00A 2zw9A-5meaA:
undetectable		 2zw9A-5meaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 399
ASP A 369
TRP A 367
PHE A 318
 None
 1.18A 3kivA-5meaA:
undetectable		 3kivA-5meaA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 381
LEU A 340
LEU A 344
ILE A 430
SER A 348
 None
 1.17A 4f4dB-5meaA:
undetectable		 4f4dB-5meaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 360
MET A 351
ARG A 353
 None
 0.69A 4lnwA-5meaA:
undetectable		 4lnwA-5meaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 360
MET A 351
ARG A 353
 None
 0.69A 4lnxA-5meaA:
undetectable		 4lnxA-5meaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 5mea CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 202
ASP A  55
LEU A  44
LYS A  46
 None
 1.11A 4ot2A-5meaA:
undetectable		 4ot2A-5meaA:
22.33