SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5med'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 9 ASN A 406
ASP A 401
PRO A 278
ALA A  21
ILE A  22
 None
 1.41A 1aj6A-5medA:
undetectable		 1aj6A-5medA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 ARG A 103
ASP A  85
ASN A  72
 None
 0.94A 1nbhA-5medA:
undetectable		 1nbhA-5medA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 12 ARG A  18
LEU A 388
TYR A 387
LEU A 404
LEU A 276
 None
 1.40A 1p33B-5medA:
undetectable		 1p33B-5medA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 12 ARG A  18
LEU A 388
TYR A 387
LEU A 404
LEU A 276
 None
 1.45A 1p33C-5medA:
undetectable		 1p33C-5medA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.69A 1rjoA-5medA:
undetectable		 1rjoA-5medA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.64A 1rkyA-5medA:
undetectable		 1rkyA-5medA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 6 ASP A  58
LEU A  61
VAL A  62
ILE A  65
 None
 0.58A 1s9qA-5medA:
undetectable		 1s9qA-5medA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 12 ALA A 496
LEU A 500
PHE A  90
VAL A  98
PRO A  96
 None
 1.28A 1vpoH-5medA:
undetectable
1vpoL-5medA:
undetectable		 1vpoH-5medA:
14.04
1vpoL-5medA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.72A 1w2zA-5medA:
undetectable		 1w2zA-5medA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.68A 1w2zB-5medA:
undetectable		 1w2zB-5medA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.70A 1w2zC-5medA:
undetectable		 1w2zC-5medA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.67A 1w2zD-5medA:
undetectable		 1w2zD-5medA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 TRP A 198
LYS A 147
PRO A 200
 None
 1.30A 2dqyB-5medA:
0.4		 2dqyB-5medA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 ASN A 453
TYR A  53
SER A 566
 FE  A1001 (-3.4A)
None
None
 0.92A 2gvcB-5medA:
undetectable		 2gvcB-5medA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 ARG A 110
GLY A 115
PRO A 116
 None
 0.71A 2hreD-5medA:
undetectable		 2hreD-5medA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 8 PHE A  90
SER A  71
ALA A 496
LEU A 500
 None
 0.91A 2o01A-5medA:
undetectable		 2o01A-5medA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.69A 2oqeA-5medA:
undetectable		 2oqeA-5medA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.69A 2oqeB-5medA:
undetectable		 2oqeB-5medA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.69A 2oqeC-5medA:
undetectable		 2oqeC-5medA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.69A 2oqeD-5medA:
undetectable		 2oqeD-5medA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.69A 2oqeF-5medA:
undetectable		 2oqeF-5medA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 ASP A 136
THR A 230
PRO A 231
 None
 0.59A 2q64B-5medA:
undetectable		 2q64B-5medA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.66A 2w0qA-5medA:
undetectable		 2w0qA-5medA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.67A 2w0qB-5medA:
undetectable		 2w0qB-5medA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 6 TYR A 163
VAL A 194
TYR A 196
ASP A 248
 None
 1.33A 2x45A-5medA:
undetectable		 2x45A-5medA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.71A 3hiiA-5medA:
undetectable		 3hiiA-5medA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.69A 3hiiB-5medA:
undetectable		 3hiiB-5medA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 ASP A 136
THR A 230
PRO A 231
 None
 0.55A 3tkgD-5medA:
undetectable		 3tkgD-5medA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 8 ILE A 121
ARG A 112
PRO A 231
TRP A 237
 None
 1.31A 4f4dB-5medA:
undetectable		 4f4dB-5medA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 10 VAL A 134
ARG A 349
ILE A 215
ALA A 214
ALA A 197
 None
 0.99A 4j14A-5medA:
undetectable		 4j14A-5medA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 LEU A 552
ARG A 551
MET A 374
 None
 0.94A 4m11C-5medA:
undetectable		 4m11C-5medA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 12 ALA A 152
ASP A 357
LEU A 364
PRO A 365
LEU A 210
 None
 1.04A 4m2xE-5medA:
undetectable		 4m2xE-5medA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		4 / 6 ALA A 152
LYS A 147
GLN A 155
LEU A 158
 None
 1.13A 4xp3A-5medA:
undetectable		 4xp3A-5medA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 12 HIS A 280
LEU A 404
LEU A 434
LEU A 388
TYR A 392
 None
 1.25A 4xumA-5medA:
undetectable		 4xumA-5medA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 ILE A 353
MET A 119
ASP A 371
 None
 0.73A 5h2uA-5medA:
undetectable		 5h2uA-5medA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		6 / 11 LEU A 286
PRO A 288
SER A 283
LEU A 282
THR A 439
ALA A 438
 None
GOL  A1005 (-3.5A)
None
None
None
None
 1.38A 5o96A-5medA:
undetectable
5o96B-5medA:
undetectable		 5o96A-5medA:
20.93
5o96B-5medA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 12 ILE A 380
PHE A 337
GLY A 446
THR A 567
LEU A 265
 None
 1.38A 5v5zA-5medA:
undetectable		 5v5zA-5medA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		3 / 3 TYR A 333
ARG A 260
THR A 261
 None
BU1  A1004 (-3.7A)
None
 0.91A 5z84J-5medA:
undetectable		 5z84J-5medA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5med ARACHIDONATE
15-LIPOXYGENASE
(Cyanothece
sp.
PCC
8801) 		5 / 12 GLN A 440
LEU A 342
ALA A 341
ILE A 540
LEU A 514
 None
 1.22A 6a5zD-5medA:
undetectable		 6a5zD-5medA:
9.39