SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 5mek CYTOSOLIC
SULFOTRANSFERASE 18
(Arabidopsis
thaliana) 		4 / 7 VAL A 173
LEU A 151
VAL A 128
LEU A 257
 None
 0.60A 1cqpA-5mekA:
undetectable
1cqpB-5mekA:
undetectable		 1cqpA-5mekA:
20.45
1cqpB-5mekA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5mek CYTOSOLIC
SULFOTRANSFERASE 18
(Arabidopsis
thaliana) 		4 / 8 ASP A 163
LYS A 167
GLY A 169
THR A 150
 None
None
None
EDO  A 414 ( 4.9A)
 0.98A 2aouA-5mekA:
undetectable		 2aouA-5mekA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 5mek CYTOSOLIC
SULFOTRANSFERASE 18
(Arabidopsis
thaliana) 		5 / 10 PRO A  92
LYS A  93
HIS A 155
PHE A 189
VAL A 305
 EDO  A 410 (-4.1A)
A3P  A 401 ( 2.8A)
EDO  A 410 ( 4.2A)
None
EDO  A 423 (-4.0A)
 1.11A 2d06A-5mekA:
29.7		 2d06A-5mekA:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 5mek CYTOSOLIC
SULFOTRANSFERASE 18
(Arabidopsis
thaliana) 		3 / 3 ASN A 308
ALA A 292
LYS A 297
 EDO  A 402 (-4.5A)
EDO  A 402 (-3.9A)
None
 0.79A 3runA-5mekA:
undetectable		 3runA-5mekA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mek CYTOSOLIC
SULFOTRANSFERASE 18
(Arabidopsis
thaliana) 		5 / 12 MET A 261
LEU A 257
VAL A 128
ALA A 101
LEU A  99
 None
 1.49A 4m11A-5mekA:
undetectable		 4m11A-5mekA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mek CYTOSOLIC
SULFOTRANSFERASE 18
(Arabidopsis
thaliana) 		5 / 12 VAL A 274
ARG A 109
VAL A 254
LEU A 257
LEU A 151
 None
EDO  A 415 ( 3.7A)
None
None
None
 1.20A 5iktB-5mekA:
undetectable		 5iktB-5mekA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 5mek CYTOSOLIC
SULFOTRANSFERASE 18
(Arabidopsis
thaliana) 		4 / 8 SER A  90
THR A  96
THR A  94
PRO A 157
 A3P  A 401 ( 4.9A)
A3P  A 401 (-3.5A)
None
None
 0.92A 5jhdE-5mekA:
undetectable
5jhdG-5mekA:
undetectable		 5jhdE-5mekA:
17.96
5jhdG-5mekA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5mek CYTOSOLIC
SULFOTRANSFERASE 18
(Arabidopsis
thaliana) 		4 / 5 PHE A 152
PHE A  86
LEU A 151
LEU A 161
 EDO  A 404 (-4.5A)
None
None
None
 1.28A 5veuH-5mekA:
undetectable		 5veuH-5mekA:
22.67