SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mev'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens;
Mus
musculus) 		3 / 3 TRP A 261
PHE A 315
TRP A 312
 None
 1.20A 1r15C-5mevA:
undetectable		 1r15C-5mevA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens;
Mus
musculus) 		3 / 3 TRP A 261
PHE A 315
TRP A 312
 None
 1.19A 1r15F-5mevA:
undetectable		 1r15F-5mevA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens;
Mus
musculus) 		3 / 3 TRP A 261
PHE A 315
TRP A 312
 None
 1.20A 1r15G-5mevA:
undetectable		 1r15G-5mevA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens;
Mus
musculus) 		3 / 3 TRP A 261
PHE A 315
TRP A 312
 None
 1.19A 1r15H-5mevA:
undetectable		 1r15H-5mevA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens;
Mus
musculus) 		5 / 12 VAL A 243
ILE A 294
VAL A 297
VAL A 253
ILE A 182
 None
None
None
7LW  A 401 (-4.0A)
None
 1.28A 1r5lA-5mevA:
undetectable		 1r5lA-5mevA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens;
Mus
musculus) 		5 / 12 ILE A 182
LEU A 306
ILE A 264
PHE A 318
ILE A 181
 None
 1.03A 2cd2A-5mevA:
undetectable		 2cd2A-5mevA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens;
Mus
musculus) 		4 / 6 LEU A 186
TYR A 185
ILE A 294
GLY A 217
 None
 0.90A 2du8A-5mevA:
undetectable		 2du8A-5mevA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens;
Mus
musculus) 		4 / 5 PRO A 289
SER A 285
LEU A 179
SER A 183
 None
 1.17A 3ijxH-5mevA:
undetectable		 3ijxH-5mevA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5mev FAB HEAVY CHAIN
INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens;
Mus
musculus) 		4 / 6 GLN A 177
ILE A 181
SER H  52
SER H  53
 None
 1.09A 3pmzD-5mevA:
undetectable		 3pmzD-5mevA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 5mev FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H 118
ALA H 120
PHE H 152
LEU H 176
 None
 0.28A 5mthA-5mevH:
26.7		 5mthA-5mevH:
70.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens;
Mus
musculus) 		5 / 12 ILE A 268
LEU A 179
VAL A 297
SER A 178
MET A 250
 None
 1.16A 6b52A-5mevA:
undetectable		 6b52A-5mevA:
18.90