SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 6 GLY A 542
ASP A 371
GLY A 708
SER A 414
 None
 0.96A 1eswA-5mfaA:
undetectable		 1eswA-5mfaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		6 / 11 LEU A 630
GLY A 645
GLY A 646
VAL A 657
LEU A 661
LEU A 626
 None
 1.41A 1mx1A-5mfaA:
undetectable		 1mx1A-5mfaA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 668
TRP A 198
VAL A 196
SER A 335
 None
 1.41A 1rs6B-5mfaA:
undetectable		 1rs6B-5mfaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 9 TYR A 500
LEU A 263
LEU A 259
ALA A 662
PHE A 669
 HEM  A 812 ( 4.3A)
None
None
None
None
 1.24A 1tbfA-5mfaA:
undetectable		 1tbfA-5mfaA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 668
TRP A 198
VAL A 196
SER A 335
 None
 1.44A 1zzqB-5mfaA:
undetectable		 1zzqB-5mfaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A69_M_RPTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 ASP A 593
ARG A 327
HIS A 594
ILE A 330
GLU A 282
 None
CL  A 816 (-3.1A)
None
CSO  A 316 ( 4.4A)
TRS  A 824 ( 4.6A)
 1.27A 2a69M-5mfaA:
0.0		 2a69M-5mfaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 GLY A 468
ALA A 662
ALA A 471
TYR A 475
ARG A 473
 None
None
None
PEG  A 819 (-4.8A)
None
 1.27A 2avdA-5mfaA:
undetectable		 2avdA-5mfaA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 6 LEU A 377
VAL A 525
MET A 509
ILE A 546
 None
 1.17A 2hyyC-5mfaA:
undetectable		 2hyyC-5mfaA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 ARG A 405
ILE A 568
HIS A 502
GLY A 256
LEU A 661
 HEM  A 812 (-3.7A)
None
HEM  A 812 (-3.3A)
HEM  A 812 (-3.3A)
None
 1.30A 2nyrB-5mfaA:
undetectable		 2nyrB-5mfaA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 ARG A 529
ARG A 536
PRO A 526
 None
 1.06A 2wljA-5mfaA:
undetectable		 2wljA-5mfaA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 7 LEU A 738
ILE A 449
ALA A 350
ILE A 176
 None
 0.78A 2xkwA-5mfaA:
undetectable		 2xkwA-5mfaA:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OGW_A_IMNA597_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 9 GLN A 257
HIS A 261
PHE A 265
ARG A 405
PHE A 573
 HEM  A 812 (-3.3A)
None
None
HEM  A 812 (-3.7A)
HEM  A 812 ( 3.9A)
 0.94A 3ogwA-5mfaA:
54.2		 3ogwA-5mfaA:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OGW_A_IMNA597_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		6 / 9 GLN A 257
HIS A 261
PHE A 265
GLU A 268
ARG A 405
PHE A 532
 HEM  A 812 (-3.3A)
None
None
HEM  A 812 ( 4.9A)
HEM  A 812 (-3.7A)
TRS  A 824 ( 4.8A)
 0.76A 3ogwA-5mfaA:
54.2		 3ogwA-5mfaA:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PY4_A_TYLA598_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
ARG A 405
PHE A 532
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
TRS  A 824 ( 4.8A)
 0.31A 3py4A-5mfaA:
54.5		 3py4A-5mfaA:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PY4_A_TYLA598_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
ARG A 405
PHE A 573
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
HEM  A 812 ( 3.9A)
 0.87A 3py4A-5mfaA:
54.5		 3py4A-5mfaA:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PY4_A_TYLA598_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
GLU A 408
PHE A 532
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-4.2A)
TRS  A 824 ( 4.8A)
 1.40A 3py4A-5mfaA:
54.5		 3py4A-5mfaA:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 7 GLN A 257
HIS A 261
ARG A 405
PHE A 532
PRO A 386
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
TRS  A 824 ( 4.8A)
TRS  A 824 ( 4.6A)
 1.34A 3ql6A-5mfaA:
54.7		 3ql6A-5mfaA:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 7 GLN A 257
HIS A 261
ARG A 405
PHE A 573
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
HEM  A 812 ( 3.9A)
 0.84A 3ql6A-5mfaA:
54.7		 3ql6A-5mfaA:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 7 GLN A 257
HIS A 261
GLU A 268
ARG A 405
PHE A 532
 HEM  A 812 (-3.3A)
None
HEM  A 812 ( 4.9A)
HEM  A 812 (-3.7A)
TRS  A 824 ( 4.8A)
 0.73A 3ql6A-5mfaA:
54.7		 3ql6A-5mfaA:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 7 HIS A 261
GLU A 408
PHE A 532
PRO A 386
 None
HEM  A 812 (-4.2A)
TRS  A 824 ( 4.8A)
TRS  A 824 ( 4.6A)
 1.32A 3ql6A-5mfaA:
54.7		 3ql6A-5mfaA:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R4X_A_PZAA597_0
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
ASP A 260
HIS A 261
ARG A 405
 HEM  A 812 (-3.3A)
HEM  A 812 (-1.1A)
None
HEM  A 812 (-3.7A)
 0.30A 3r4xA-5mfaA:
54.6		 3r4xA-5mfaA:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R55_A_PZAA597_0
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
ASP A 260
HIS A 261
ARG A 405
 HEM  A 812 (-3.3A)
HEM  A 812 (-1.1A)
None
HEM  A 812 (-3.7A)
 0.25A 3r55A-5mfaA:
54.8		 3r55A-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R55_A_PZAA597_0
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
ASP A 260
HIS A 261
GLU A 408
 HEM  A 812 (-3.3A)
HEM  A 812 (-1.1A)
None
HEM  A 812 (-4.2A)
 1.02A 3r55A-5mfaA:
54.8		 3r55A-5mfaA:
49.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 10 GLY A 598
TYR A 211
SER A 591
GLU A 202
ASP A 641
 None
 1.46A 3s68A-5mfaA:
undetectable		 3s68A-5mfaA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 LYS A 448
SER A 687
GLN A 690
 None
 1.32A 3si7A-5mfaA:
undetectable		 3si7A-5mfaA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 LEU A 476
ARG A 673
ILE A 456
ARG A 460
 None
 1.04A 3ticA-5mfaA:
undetectable		 3ticA-5mfaA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 TYR A 173
MET A 453
LEU A 426
 None
 0.98A 3vw1D-5mfaA:
undetectable		 3vw1D-5mfaA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 11 MET A 644
GLY A 646
THR A 495
ARG A 592
GLY A 598
 None
None
HEM  A 812 (-4.2A)
None
None
 1.50A 3wg7A-5mfaA:
0.6
3wg7B-5mfaA:
undetectable
3wg7T-5mfaA:
undetectable		 3wg7A-5mfaA:
20.36
3wg7B-5mfaA:
16.16
3wg7T-5mfaA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 10 ARG A 592
GLY A 598
MET A 644
GLY A 646
THR A 495
 None
None
None
None
HEM  A 812 (-4.2A)
 1.49A 3x2qG-5mfaA:
undetectable
3x2qN-5mfaA:
0.1
3x2qO-5mfaA:
undetectable		 3x2qG-5mfaA:
8.32
3x2qN-5mfaA:
20.36
3x2qO-5mfaA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 7 PHE A 669
VAL A 466
GLY A 256
PHE A 494
 None
None
HEM  A 812 (-3.3A)
None
 0.75A 4ejjB-5mfaA:
undetectable		 4ejjB-5mfaA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 ARG A 569
TYR A 500
ASN A 496
 None
HEM  A 812 ( 4.3A)
None
 0.86A 4ffwB-5mfaA:
undetectable		 4ffwB-5mfaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 LEU A 360
LEU A 362
ASN A 355
LEU A 363
ALA A 364
 None
None
NAG  A 807 (-2.0A)
None
NAG  A 807 (-3.8A)
 1.16A 4fn9B-5mfaA:
undetectable		 4fn9B-5mfaA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 ASP A 566
ARG A 569
ASP A 240
 None
 0.57A 4fp9C-5mfaA:
undetectable		 4fp9C-5mfaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 ASP A 566
ARG A 569
ASP A 240
 None
 0.60A 4fp9F-5mfaA:
undetectable		 4fp9F-5mfaA:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IG5_A_MMZA616_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
ARG A 405
LEU A 412
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
None
 0.37A 4ig5A-5mfaA:
54.3		 4ig5A-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IG5_A_MMZA616_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
GLU A 408
LEU A 412
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-4.2A)
None
 0.91A 4ig5A-5mfaA:
54.3		 4ig5A-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IG5_B_MMZB617_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
ARG A 405
LEU A 412
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
None
 0.31A 4ig5B-5mfaA:
54.5		 4ig5B-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IG5_B_MMZB617_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
GLU A 408
LEU A 412
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-4.2A)
None
 0.97A 4ig5B-5mfaA:
54.5		 4ig5B-5mfaA:
49.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 9 TYR A 634
VAL A 235
ILE A 563
LEU A 617
LEU A 621
 None
 1.37A 4l1xB-5mfaA:
undetectable		 4l1xB-5mfaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 11 GLY A 361
GLY A 439
ALA A 446
LEU A 442
HIS A 423
 None
 1.10A 4l8fB-5mfaA:
undetectable		 4l8fB-5mfaA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 11 GLY A 361
GLY A 439
ALA A 446
LEU A 442
HIS A 423
 None
 1.07A 4l8fD-5mfaA:
undetectable		 4l8fD-5mfaA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 HIS A 594
TRP A 602
SER A 315
 None
None
CSO  A 316 ( 4.3A)
 0.99A 4lrhD-5mfaA:
undetectable		 4lrhD-5mfaA:
13.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 GLN A 257
HIS A 261
ARG A 405
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
 0.36A 4qyqA-5mfaA:
53.7		 4qyqA-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 GLN A 257
HIS A 261
ARG A 405
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
 0.30A 4qyqB-5mfaA:
53.6		 4qyqB-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 6 GLN A 257
ASP A 260
HIS A 261
ARG A 405
ARG A 499
 HEM  A 812 (-3.3A)
HEM  A 812 (-1.1A)
None
HEM  A 812 (-3.7A)
HEM  A 812 (-2.8A)
 0.38A 4qyqC-5mfaA:
16.3		 4qyqC-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 6 GLN A 257
ASP A 260
HIS A 261
GLU A 408
ARG A 499
 HEM  A 812 (-3.3A)
HEM  A 812 (-1.1A)
None
HEM  A 812 (-4.2A)
HEM  A 812 (-2.8A)
 1.06A 4qyqC-5mfaA:
16.3		 4qyqC-5mfaA:
49.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 GLU A 347
TYR A 443
GLU A 440
 None
 0.83A 4ryaA-5mfaA:
undetectable		 4ryaA-5mfaA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 ILE A 579
ASP A 308
ALA A 229
ALA A 227
ASN A 232
 None
 1.24A 4u14A-5mfaA:
undetectable		 4u14A-5mfaA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 4 LEU A 621
VAL A 620
GLU A 649
ARG A 603
 None
 1.46A 4ww7A-5mfaA:
undetectable		 4ww7A-5mfaA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLY A 598
SER A 591
GLU A 202
ASP A 641
 None
 1.21A 4xueA-5mfaA:
undetectable		 4xueA-5mfaA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 TYR A 634
VAL A 235
ILE A 563
LEU A 617
LEU A 621
 None
 1.24A 4yvpB-5mfaA:
undetectable		 4yvpB-5mfaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 11 MET A 644
GLY A 646
THR A 495
ARG A 592
GLY A 598
 None
None
HEM  A 812 (-4.2A)
None
None
 1.48A 5b1aA-5mfaA:
undetectable
5b1aB-5mfaA:
undetectable
5b1aT-5mfaA:
undetectable		 5b1aA-5mfaA:
20.36
5b1aB-5mfaA:
16.16
5b1aT-5mfaA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 11 ARG A 592
GLY A 598
MET A 644
GLY A 646
THR A 495
 None
None
None
None
HEM  A 812 (-4.2A)
 1.50A 5b1bG-5mfaA:
undetectable
5b1bN-5mfaA:
0.0
5b1bO-5mfaA:
undetectable		 5b1bG-5mfaA:
8.32
5b1bN-5mfaA:
20.36
5b1bO-5mfaA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 11 MET A 644
GLY A 646
THR A 495
ARG A 592
GLY A 598
 None
None
HEM  A 812 (-4.2A)
None
None
 1.49A 5b3sA-5mfaA:
undetectable
5b3sB-5mfaA:
undetectable
5b3sT-5mfaA:
undetectable		 5b3sA-5mfaA:
20.36
5b3sB-5mfaA:
16.16
5b3sT-5mfaA:
8.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FF1_A_MMZA601_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
ARG A 405
LEU A 412
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
None
 0.24A 5ff1A-5mfaA:
54.4		 5ff1A-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FF1_A_MMZA601_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
GLU A 408
LEU A 412
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-4.2A)
None
 0.95A 5ff1A-5mfaA:
54.4		 5ff1A-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FF1_A_MMZA602_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
ARG A 405
LEU A 412
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
None
 0.24A 5ff1A-5mfaA:
54.4		 5ff1A-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FF1_A_MMZA602_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
GLU A 408
LEU A 412
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-4.2A)
None
 0.95A 5ff1A-5mfaA:
54.4		 5ff1A-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FF1_B_MMZB601_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
ARG A 405
LEU A 412
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
None
 0.25A 5ff1B-5mfaA:
54.6		 5ff1B-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FF1_B_MMZB601_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
GLU A 408
LEU A 412
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-4.2A)
None
 0.94A 5ff1B-5mfaA:
54.6		 5ff1B-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FF1_B_MMZB613_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
ARG A 405
LEU A 412
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
None
 0.25A 5ff1B-5mfaA:
54.6		 5ff1B-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FF1_B_MMZB613_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
GLU A 408
LEU A 412
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-4.2A)
None
 0.94A 5ff1B-5mfaA:
54.6		 5ff1B-5mfaA:
49.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHQ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 9 GLY A 598
TYR A 211
SER A 591
GLU A 202
ASP A 641
 None
 1.47A 5fhqA-5mfaA:
0.0		 5fhqA-5mfaA:
14.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_A_3CJA609_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
ARG A 405
ARG A 499
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
HEM  A 812 (-2.8A)
 0.38A 5hpwA-5mfaA:
53.7		 5hpwA-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_A_3CJA609_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 GLN A 257
HIS A 261
GLU A 408
ARG A 499
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-4.2A)
HEM  A 812 (-2.8A)
 1.09A 5hpwA-5mfaA:
53.7		 5hpwA-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_B_3CJB609_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 4 GLN A 257
HIS A 261
ARG A 405
ARG A 499
 HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
HEM  A 812 (-2.8A)
 0.33A 5hpwB-5mfaA:
53.6		 5hpwB-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 6 GLN A 257
ASP A 260
HIS A 261
ARG A 405
ARG A 499
 HEM  A 812 (-3.3A)
HEM  A 812 (-1.1A)
None
HEM  A 812 (-3.7A)
HEM  A 812 (-2.8A)
 0.38A 5hpwC-5mfaA:
16.3		 5hpwC-5mfaA:
49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 6 GLN A 257
ASP A 260
HIS A 261
GLU A 408
ARG A 499
 HEM  A 812 (-3.3A)
HEM  A 812 (-1.1A)
None
HEM  A 812 (-4.2A)
HEM  A 812 (-2.8A)
 1.06A 5hpwC-5mfaA:
16.3		 5hpwC-5mfaA:
49.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 THR A 334
THR A 177
ARG A 447
SER A 340
GLY A 344
 CA  A 813 (-3.6A)
None
None
CA  A 813 (-2.3A)
None
 1.29A 5l5zV-5mfaA:
undetectable
5l5zb-5mfaA:
undetectable		 5l5zV-5mfaA:
16.47
5l5zb-5mfaA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 THR A 334
THR A 177
ARG A 447
SER A 340
GLY A 344
 CA  A 813 (-3.6A)
None
None
CA  A 813 (-2.3A)
None
 1.29A 5l5zH-5mfaA:
undetectable
5l5zN-5mfaA:
undetectable		 5l5zH-5mfaA:
16.47
5l5zN-5mfaA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 THR A 334
ARG A 447
SER A 340
GLY A 344
ALA A 350
 CA  A 813 (-3.6A)
None
CA  A 813 (-2.3A)
None
None
 1.40A 5lf3b-5mfaA:
undetectable		 5lf3b-5mfaA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 THR A 334
THR A 177
ARG A 447
SER A 340
GLY A 344
 CA  A 813 (-3.6A)
None
None
CA  A 813 (-2.3A)
None
 1.27A 5lf3b-5mfaA:
undetectable		 5lf3b-5mfaA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 THR A 334
ARG A 447
SER A 340
GLY A 344
ALA A 350
 CA  A 813 (-3.6A)
None
CA  A 813 (-2.3A)
None
None
 1.40A 5lf3N-5mfaA:
undetectable		 5lf3N-5mfaA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 THR A 334
THR A 177
ARG A 447
SER A 340
GLY A 344
 CA  A 813 (-3.6A)
None
None
CA  A 813 (-2.3A)
None
 1.28A 5lf3N-5mfaA:
undetectable		 5lf3N-5mfaA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		4 / 9 TYR A 462
ILE A 457
ILE A 697
LEU A 694
 None
 0.79A 5vkqB-5mfaA:
undetectable
5vkqC-5mfaA:
undetectable		 5vkqB-5mfaA:
17.93
5vkqC-5mfaA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		5 / 10 MET A 644
GLY A 646
THR A 495
ARG A 592
GLY A 598
 None
None
HEM  A 812 (-4.2A)
None
None
 1.47A 5wauA-5mfaA:
0.9
5wauB-5mfaA:
undetectable
5waug-5mfaA:
undetectable		 5wauA-5mfaA:
20.36
5wauB-5mfaA:
16.16
5waug-5mfaA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5mfa MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 ASP A 566
ARG A 236
ASP A 240
 None
 0.88A 5zvgA-5mfaA:
undetectable		 5zvgA-5mfaA:
21.08