SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 6 VAL A 116
VAL A 195
ASN A 198
ILE A 161
 None
 0.92A 1e06A-5mfbA:
undetectable		 1e06A-5mfbA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 5 LEU A  55
GLU A  93
ALA A  96
LEU A  58
 None
 0.94A 1eta1-5mfbA:
undetectable		 1eta1-5mfbA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 5 LEU A  97
GLU A 135
ALA A 138
LEU A 100
 None
 0.89A 1eta1-5mfbA:
undetectable		 1eta1-5mfbA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 5 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.93A 1eta1-5mfbA:
undetectable		 1eta1-5mfbA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 5 LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 0.93A 1eta1-5mfbA:
undetectable		 1eta1-5mfbA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 5 LEU A  55
GLU A  93
ALA A  96
LEU A  58
 None
 0.95A 1eta2-5mfbA:
undetectable		 1eta2-5mfbA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 5 LEU A  97
GLU A 135
ALA A 138
LEU A 100
 None
 0.89A 1eta2-5mfbA:
undetectable		 1eta2-5mfbA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 5 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.94A 1eta2-5mfbA:
undetectable		 1eta2-5mfbA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 5 LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 0.92A 1eta2-5mfbA:
undetectable		 1eta2-5mfbA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 6 LEU A  55
GLU A  93
ALA A  96
LEU A  58
 None
 0.93A 1etb1-5mfbA:
undetectable		 1etb1-5mfbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 6 LEU A  97
GLU A 135
ALA A 138
LEU A 100
 None
 0.88A 1etb1-5mfbA:
undetectable		 1etb1-5mfbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 6 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.93A 1etb1-5mfbA:
undetectable		 1etb1-5mfbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 6 LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 0.91A 1etb1-5mfbA:
undetectable		 1etb1-5mfbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 6 LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 0.94A 1etb2-5mfbA:
undetectable		 1etb2-5mfbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 6 LEU A  97
GLU A 135
ALA A 138
LEU A 100
 None
 0.86A 1sn5A-5mfbA:
undetectable		 1sn5A-5mfbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 6 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.89A 1sn5A-5mfbA:
undetectable		 1sn5A-5mfbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 8 LEU A  97
GLU A 135
ALA A 138
LEU A 100
 None
 0.87A 1sn5C-5mfbA:
undetectable		 1sn5C-5mfbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 8 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.90A 1sn5C-5mfbA:
undetectable		 1sn5C-5mfbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 11 LEU A 175
LEU A 139
ILE A 161
LEU A 146
ASP A 147
 None
 1.25A 2qeiA-5mfbA:
undetectable		 2qeiA-5mfbA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 10 LEU A  61
LEU A  58
LEU A  35
LYS A  34
LEU A  20
 None
 1.14A 2riwA-5mfbA:
undetectable
2riwB-5mfbA:
undetectable		 2riwA-5mfbA:
23.86
2riwB-5mfbA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 7 ASN A 205
ALA A 244
ALA A 243
ALA A 247
 None
 0.87A 3a2qA-5mfbA:
undetectable		 3a2qA-5mfbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 12 ALA A 157
SER A 150
ASP A 147
LEU A 146
ALA A 120
 None
 1.10A 3ou6A-5mfbA:
undetectable		 3ou6A-5mfbA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 12 ALA A 199
SER A 192
ASP A 189
LEU A 188
ALA A 162
 None
 1.09A 3ou6A-5mfbA:
undetectable		 3ou6A-5mfbA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 12 ALA A 157
SER A 150
ASP A 147
LEU A 146
ALA A 120
 None
 1.13A 3ou6C-5mfbA:
undetectable		 3ou6C-5mfbA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 12 ALA A 199
SER A 192
ASP A 189
LEU A 188
ALA A 162
 None
 1.10A 3ou6C-5mfbA:
undetectable		 3ou6C-5mfbA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 12 SER A 140
ALA A 120
LEU A 146
LEU A 184
ASN A 163
 None
 1.08A 3r9cA-5mfbA:
undetectable		 3r9cA-5mfbA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 12 SER A 182
ALA A 162
LEU A 188
LEU A 226
ASN A 205
 None
 1.06A 3r9cA-5mfbA:
undetectable		 3r9cA-5mfbA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 4 LEU A 145
ALA A 115
ILE A 119
LYS A 144
 None
 1.49A 4eixA-5mfbA:
undetectable		 4eixA-5mfbA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 12 ALA A 166
LEU A 175
ASN A 240
GLU A 194
ALA A 159
 None
 1.14A 4pclA-5mfbA:
undetectable		 4pclA-5mfbA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 12 ALA A 180
ALA A 204
ILE A 203
ASN A 169
ASN A 210
 None
 1.13A 4r38A-5mfbA:
undetectable		 4r38A-5mfbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 12 ALA A  96
ALA A 120
ILE A 119
ASN A  85
ASN A 126
 None
 1.13A 4r38B-5mfbA:
undetectable		 4r38B-5mfbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 12 ALA A 180
ALA A 204
ILE A 203
ASN A 169
ASN A 210
 None
 1.09A 4r3aA-5mfbA:
undetectable		 4r3aA-5mfbA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 12 ALA A 180
ALA A 204
ILE A 203
ASN A 169
ASN A 210
 None
 0.98A 4r3aB-5mfbA:
undetectable		 4r3aB-5mfbA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		5 / 12 GLU A 177
GLU A 170
GLY A 209
ALA A 207
ILE A 203
 None
 1.25A 4xe5A-5mfbA:
undetectable		 4xe5A-5mfbA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 5 SER A  56
VAL A  59
GLY A  95
ALA A  94
 None
 1.06A 5k50A-5mfbA:
undetectable		 5k50A-5mfbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 5 SER A 140
VAL A 143
GLY A 179
ALA A 178
 None
 1.04A 5k50A-5mfbA:
undetectable		 5k50A-5mfbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5mfb YIII(DQ)4CQI
(synthetic
construct) 		4 / 8 LEU A 229
ALA A 225
ALA A 244
LEU A 245
 None
 0.84A 5te8B-5mfbA:
undetectable		 5te8B-5mfbA:
20.00