SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5mfd YIIIM''6AII
(synthetic
construct) 		5 / 12 ALA A 123
ILE A 195
LEU A 146
LEU A 139
LEU A 116
 None
 1.37A 1eiiA-5mfdA:
undetectable		 1eiiA-5mfdA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5mfd YIIIM''6AII
(synthetic
construct) 		5 / 12 ALA A 165
ILE A 237
LEU A 188
LEU A 181
LEU A 158
 None
 1.28A 1eiiA-5mfdA:
undetectable		 1eiiA-5mfdA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5mfd YIIIM''6AII
(synthetic
construct) 		4 / 5 LEU A 265
GLU A 303
ALA A 306
LEU A 268
 None
 0.87A 1eta1-5mfdA:
undetectable		 1eta1-5mfdA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5mfd YIIIM''6AII
(synthetic
construct) 		4 / 5 LEU A 265
GLU A 303
ALA A 306
LEU A 268
 None
 0.87A 1eta2-5mfdA:
undetectable		 1eta2-5mfdA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5mfd YIIIM''6AII
(synthetic
construct) 		4 / 6 LEU A 265
GLU A 303
ALA A 306
LEU A 268
 None
 0.88A 1etb1-5mfdA:
undetectable		 1etb1-5mfdA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5mfd YIIIM''6AII
(synthetic
construct) 		5 / 11 LEU A 332
LEU A 265
GLU A 303
ALA A 306
LEU A 268
 None
 1.11A 1ictA-5mfdA:
undetectable
1ictC-5mfdA:
undetectable		 1ictA-5mfdA:
17.76
1ictC-5mfdA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5mfd YIIIM''6AII
(synthetic
construct) 		5 / 10 LEU A 265
GLU A 303
ALA A 306
LEU A 268
LEU A 332
 None
 1.08A 1ie4A-5mfdA:
undetectable
1ie4C-5mfdA:
undetectable		 1ie4A-5mfdA:
17.78
1ie4C-5mfdA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5mfd YIIIM''6AII
(synthetic
construct) 		5 / 10 LEU A 332
LEU A 265
GLU A 303
ALA A 306
LEU A 268
 None
 1.07A 1ie4A-5mfdA:
undetectable
1ie4C-5mfdA:
undetectable		 1ie4A-5mfdA:
17.78
1ie4C-5mfdA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5mfd YIIIM''6AII
(synthetic
construct) 		5 / 11 GLY A 162
GLU A 198
GLU A 240
SER A 166
ASN A 163
 None
None
CA  A 406 ( 4.2A)
None
None
 1.44A 1odiE-5mfdA:
undetectable		 1odiE-5mfdA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5mfd YIIIM''6AII
(synthetic
construct) 		4 / 7 LEU A 265
GLU A 303
ALA A 306
LEU A 332
 None
 0.94A 1sn0B-5mfdA:
undetectable
1sn0D-5mfdA:
undetectable		 1sn0B-5mfdA:
18.81
1sn0D-5mfdA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5mfd YIIIM''6AII
(synthetic
construct) 		4 / 6 LEU A 265
GLU A 303
ALA A 306
LEU A 268
 None
 0.75A 1sn5A-5mfdA:
undetectable		 1sn5A-5mfdA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 5mfd YIIIM''6AII
(synthetic
construct) 		5 / 12 ALA A  90
GLY A  84
GLY A  83
VAL A  49
ILE A  50
 None
 0.85A 3cyxB-5mfdA:
undetectable		 3cyxB-5mfdA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 5mfd YIIIM''6AII
(synthetic
construct) 		4 / 5 LEU A 307
GLN A 312
LEU A 310
GLU A 311
 None
 1.07A 3h5gA-5mfdA:
undetectable
3h5gB-5mfdA:
undetectable		 3h5gA-5mfdA:
6.44
3h5gB-5mfdA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 5mfd YIIIM''6AII
(synthetic
construct) 		5 / 10 LEU A 119
GLY A  78
ALA A  81
VAL A 133
ILE A 122
 None
 1.09A 3nu6B-5mfdA:
undetectable		 3nu6B-5mfdA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 5mfd YIIIM''6AII
(synthetic
construct) 		4 / 5 GLY A 251
ILE A 290
LYS A 298
GLN A 297
 None
 0.92A 4ma8C-5mfdA:
undetectable		 4ma8C-5mfdA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5mfd YIIIM''6AII
CAPSID DECORATION
PROTEIN,PD_(KR)5
(synthetic
construct;
Escherichia
virus
Lambda) 		5 / 12 ALA A 123
ILE A  88
ASN A  85
GLY A 126
ARG B 118
 None
 1.19A 4obwD-5mfdA:
undetectable		 4obwD-5mfdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5mfd YIIIM''6AII
CAPSID DECORATION
PROTEIN,PD_(KR)5
(synthetic
construct;
Escherichia
virus
Lambda) 		5 / 12 ALA A 165
ILE A 130
ASN A 127
ARG B 118
ASN A 163
 None
 1.29A 4obwD-5mfdA:
undetectable		 4obwD-5mfdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5mfd YIIIM''6AII
CAPSID DECORATION
PROTEIN,PD_(KR)5
(synthetic
construct;
Escherichia
virus
Lambda) 		5 / 12 ALA A 165
ILE A 130
ASN A 127
GLY A 168
ARG B 116
 None
None
None
None
CA  A 406 ( 4.9A)
 1.25A 4obwD-5mfdA:
undetectable		 4obwD-5mfdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5mfd YIIIM''6AII
CAPSID DECORATION
PROTEIN,PD_(KR)5
(synthetic
construct;
Escherichia
virus
Lambda) 		5 / 12 ALA A 165
ILE A 130
ASN A 127
GLY A 168
ARG B 118
 None
 1.28A 4obwD-5mfdA:
undetectable		 4obwD-5mfdA:
22.97