SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mfo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5mfo YIIIM3AIII
(synthetic
construct) 		5 / 12 ALA A  39
ILE A 111
LEU A  62
LEU A  55
LEU A  32
 None
 1.27A 1eiiA-5mfoA:
undetectable		 1eiiA-5mfoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5mfo YIIIM3AIII
(synthetic
construct) 		5 / 12 ALA A  81
ILE A 153
LEU A 104
LEU A  97
LEU A  74
 None
 1.34A 1eiiA-5mfoA:
undetectable		 1eiiA-5mfoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5mfo YIIIM3AIII
(synthetic
construct) 		4 / 5 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.87A 1eta1-5mfoA:
undetectable		 1eta1-5mfoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5mfo YIIIM3AIII
(synthetic
construct) 		4 / 5 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.85A 1eta2-5mfoA:
undetectable		 1eta2-5mfoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5mfo YIIIM3AIII
(synthetic
construct) 		4 / 6 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.86A 1etb1-5mfoA:
undetectable		 1etb1-5mfoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5mfo YIIIM3AIII
(synthetic
construct) 		5 / 11 LEU A  61
ALA A  57
GLU A  27
LEU A  35
SER A  36
 None
 0.98A 1ictA-5mfoA:
undetectable
1ictC-5mfoA:
undetectable		 1ictA-5mfoA:
21.94
1ictC-5mfoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5mfo YIIIM3AIII
(synthetic
construct) 		5 / 10 ALA A  99
LEU A  97
LEU A  74
ALA A 118
LEU A  77
 None
 1.36A 1ie4A-5mfoA:
undetectable
1ie4C-5mfoA:
undetectable		 1ie4A-5mfoA:
20.39
1ie4C-5mfoA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5mfo YIIIM3AIII
(synthetic
construct) 		5 / 10 LEU A  74
ALA A 118
LEU A  77
ALA A  99
LEU A  97
 None
 1.30A 1ie4A-5mfoA:
undetectable
1ie4C-5mfoA:
undetectable		 1ie4A-5mfoA:
20.39
1ie4C-5mfoA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5mfo YIIIM3AIII
(synthetic
construct) 		4 / 6 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.87A 1sn5A-5mfoA:
undetectable		 1sn5A-5mfoA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5mfo YIIIM3AIII
(synthetic
construct) 		5 / 10 LEU A  61
LEU A  58
LEU A  35
LYS A  34
LEU A  20
 None
 1.14A 2riwA-5mfoA:
undetectable
2riwB-5mfoA:
undetectable		 2riwA-5mfoA:
21.18
2riwB-5mfoA:
12.70