SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mg3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
(Escherichia
coli) 		3 / 3 GLU D 391
ALA D 292
SER D 295
 None
 0.66A 1errB-5mg3D:
undetectable		 1errB-5mg3D:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		4 / 5 GLU F 132
LEU F  50
ASP F  51
LEU F 142
 None
 1.08A 1n13B-5mg3F:
undetectable
1n13C-5mg3F:
undetectable		 1n13B-5mg3F:
15.74
1n13C-5mg3F:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		4 / 6 GLU F 132
LEU F  50
ASP F  51
GLY D 573
 None
 0.86A 1n13H-5mg3F:
undetectable
1n13K-5mg3F:
undetectable		 1n13H-5mg3F:
15.74
1n13K-5mg3F:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		4 / 7 LEU F  50
ASP F  51
GLY D 573
GLU F 132
 None
 0.83A 1n13G-5mg3F:
undetectable
1n13J-5mg3F:
undetectable		 1n13G-5mg3F:
12.06
1n13J-5mg3F:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		4 / 6 ASP F 213
SER F 214
VAL F 173
GLY F 284
 None
 0.63A 1tnlA-5mg3F:
undetectable		 1tnlA-5mg3F:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
(Escherichia
coli) 		5 / 9 LEU D 603
LEU D   2
PHE D 475
ILE D 478
TYR D  10
 None
 1.19A 2f78A-5mg3D:
undetectable		 2f78A-5mg3D:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
(Escherichia
coli) 		5 / 9 LEU D 603
LEU D   2
PHE D 475
ILE D 478
TYR D  10
 None
 1.22A 2f78B-5mg3D:
undetectable		 2f78B-5mg3D:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli;
Escherichia
coli) 		5 / 12 PHE D 578
TYR D 568
ALA D 574
ALA F 201
GLY D 506
 None
 1.09A 2igtA-5mg3D:
undetectable		 2igtA-5mg3D:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli;
Escherichia
coli) 		5 / 12 PHE D 578
TYR D 568
ALA D 574
ALA F 201
GLY D 506
 None
 1.09A 2igtB-5mg3D:
undetectable		 2igtB-5mg3D:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
(Escherichia
coli) 		3 / 3 VAL D 257
GLU D 438
GLU D 437
 None
 0.75A 2nv4A-5mg3D:
undetectable		 2nv4A-5mg3D:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
(Escherichia
coli) 		4 / 5 LEU D 424
ALA D 428
LEU D 279
MET D 365
 None
 0.95A 2oaxA-5mg3D:
undetectable		 2oaxA-5mg3D:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		4 / 6 ASP F 213
SER F 214
VAL F 173
GLY F 284
 None
 0.60A 2otvA-5mg3F:
undetectable		 2otvA-5mg3F:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		4 / 8 GLU F 132
LEU F  50
ASP F  51
GLY D 573
 None
 0.85A 2qqdB-5mg3F:
undetectable
2qqdC-5mg3F:
undetectable		 2qqdB-5mg3F:
17.89
2qqdC-5mg3F:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli;
Escherichia
coli) 		4 / 6 SER D 552
GLU D 531
SER F 240
ASP F 219
 None
 1.17A 2zvjA-5mg3D:
undetectable		 2zvjA-5mg3D:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
(Escherichia
coli) 		5 / 12 LEU D 424
THR D 367
VAL D 392
THR D 409
ILE D 408
 None
 1.07A 3bf1A-5mg3D:
undetectable
3bf1B-5mg3D:
undetectable		 3bf1A-5mg3D:
17.18
3bf1B-5mg3D:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
(Escherichia
coli) 		4 / 7 VAL D 238
ILE D 233
GLY D 427
LEU D 279
 None
 0.90A 3bjwF-5mg3D:
undetectable		 3bjwF-5mg3D:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
(Escherichia
coli) 		6 / 11 ARG D 439
ILE D 430
GLY D 274
LEU D 273
VAL D 248
ILE D 256
 None
 1.49A 3em4U-5mg3D:
undetectable		 3em4U-5mg3D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		5 / 12 TYR F 263
ILE F 283
VAL F 181
ILE F 183
ILE F 187
 None
 1.14A 3fpjB-5mg3F:
undetectable		 3fpjB-5mg3F:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_1
(METHYLTRANSFERASE)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli;
Escherichia
coli) 		5 / 9 SER F 121
GLY D 242
ASN F 125
GLU D 303
ASN F 119
 None
 1.19A 3ndiA-5mg3F:
undetectable		 3ndiA-5mg3F:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		4 / 6 GLN D 452
ILE D 441
SER F  90
SER F  91
 None
 1.30A 3pmzD-5mg3D:
undetectable		 3pmzD-5mg3D:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		4 / 5 ASP F 213
SER F 214
VAL F 173
GLY F 284
 None
 0.65A 3rxhA-5mg3F:
undetectable		 3rxhA-5mg3F:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
(Escherichia
coli) 		4 / 5 LEU D 483
ALA D 520
MET D 468
ASN D 525
 None
 1.14A 3uq6A-5mg3D:
undetectable		 3uq6A-5mg3D:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
(Escherichia
coli) 		5 / 12 ILE D 524
ILE D 553
ALA D 520
ALA D 482
PHE D 554
 None
 1.02A 3uvvA-5mg3D:
undetectable		 3uvvA-5mg3D:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		5 / 11 ILE F 199
ASP F 196
ILE F 195
GLY F  49
GLY F  45
 None
 1.10A 4ac9B-5mg3F:
undetectable
4ac9C-5mg3F:
undetectable		 4ac9B-5mg3F:
22.42
4ac9C-5mg3F:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		5 / 12 ILE D 575
THR D 572
ASP F  51
GLU F 132
GLU F  59
 None
 1.37A 4i41A-5mg3D:
undetectable		 4i41A-5mg3D:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		5 / 12 GLU F 194
ARG F  97
ILE F  40
GLY F 186
LEU F 185
 None
 1.30A 4j26A-5mg3F:
undetectable		 4j26A-5mg3F:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli;
Escherichia
coli) 		3 / 3 ARG D 527
ASP F 219
ARG D 536
 None
 0.96A 4mx0A-5mg3D:
undetectable		 4mx0A-5mg3D:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		5 / 12 GLY F  55
GLY F  54
ALA F 143
GLN F 144
ASP F 196
 None
 1.19A 4ubeA-5mg3F:
undetectable		 4ubeA-5mg3F:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli;
Escherichia
coli) 		4 / 4 SER D 552
GLU D 531
SER F 240
ASP F 219
 None
 1.18A 4xucA-5mg3D:
undetectable		 4xucA-5mg3D:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
(Escherichia
coli) 		5 / 10 ILE D 435
LEU D 234
VAL D 370
ILE D 272
LEU D 386
 None
 1.18A 5ienB-5mg3D:
undetectable		 5ienB-5mg3D:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		5 / 12 ILE D 450
ASP F  51
ALA F 201
GLY D 571
THR D 572
 None
 1.12A 5igiA-5mg3D:
0.3		 5igiA-5mg3D:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
(Escherichia
coli) 		4 / 8 PHE D 406
LEU D 345
ILE D 398
ASN D 360
 None
 0.85A 5nujA-5mg3D:
undetectable		 5nujA-5mg3D:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		5 / 9 LEU D 512
VAL D 516
ILE F 157
LEU D 567
ALA D 556
 None
 1.26A 5og9A-5mg3D:
undetectable		 5og9A-5mg3D:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF
(Escherichia
coli) 		5 / 12 ILE D 465
SER F 205
ILE D 507
LEU D 514
ALA D 515
 None
 1.28A 5oy02-5mg3D:
undetectable		 5oy02-5mg3D:
8.19