SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 10 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.43A 1fk9A-5mg5A:
undetectable
1fk9A-5mg5A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 11 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.39A 1fkpA-5mg5A:
undetectable
1fkpA-5mg5A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 12 THR A  84
LEU A  49
GLY A 162
GLY A 276
ALA A 142
None
1.11A 1httD-5mg5A:
undetectable
1httD-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 9 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.45A 1ikvA-5mg5A:
undetectable
1ikvA-5mg5A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 10 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.39A 1ikwA-5mg5A:
undetectable
1ikwA-5mg5A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 TYR C 386
VAL C 297
ALA C 388
SER C 274
LEU C 257
None
1.39A 1kiaD-5mg5C:
undetectable
1kiaD-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 10 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.42A 1lw0A-5mg5A:
undetectable
1lw0A-5mg5A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 11 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.44A 1lwcA-5mg5A:
undetectable
1lwcA-5mg5A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 9 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.43A 1lwfA-5mg5A:
undetectable
1lwfA-5mg5A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 GLU C 165
GLY C 302
VAL C 168
ALA C 149
LEU C 383
None
1.25A 1nw3A-5mg5C:
undetectable
1nw3A-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 10 ALA A 275
LEU A 282
LEU A 281
ILE A 140
LEU A  58
None
1.28A 1pcgA-5mg5A:
undetectable
1pcgA-5mg5A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 10 GLY C 326
VAL C 323
ILE C 328
TYR C 179
GLY C 332
None
1.41A 1pn0C-5mg5C:
undetectable
1pn0C-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 10 GLY C 326
VAL C 323
ILE C 328
TYR C 179
GLY C 332
None
1.40A 1pn0D-5mg5C:
undetectable
1pn0D-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 GLY C 114
GLY C 216
ALA C 214
PHE C  95
SER C  91
None
1.15A 1ri4A-5mg5C:
undetectable
1ri4A-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 6 ALA A  77
LEU A  78
ILE A  75
SER A 136
None
1.08A 1sbrA-5mg5A:
undetectable
1sbrB-5mg5A:
undetectable
1sbrA-5mg5A:
20.11
1sbrB-5mg5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 11 SER C 274
ILE C 377
VAL C 379
ALA C 295
ILE C 313
None
1.16A 1uduA-5mg5C:
undetectable
1uduA-5mg5C:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 9 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.42A 1vrtA-5mg5A:
undetectable
1vrtA-5mg5A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
6 / 12 ALA A 164
ALA A  13
LEU A 329
LEU A 281
ALA A 278
ILE A 174
None
1.28A 2aclA-5mg5A:
undetectable
2aclE-5mg5A:
undetectable
2aclA-5mg5A:
14.91
2aclE-5mg5A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 11 ALA A 164
ALA A  13
LEU A 329
ALA A 278
ILE A 174
None
1.06A 2aclE-5mg5A:
undetectable
2aclE-5mg5A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 LEU C 360
ASN C 337
CYH C 277
ASN C 382
ALA C 240
None
None
None
SCY  C  88 ( 3.5A)
None
1.09A 2bm9C-5mg5C:
undetectable
2bm9C-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
4 / 6 THR C 183
SER C 368
ASP C 369
VAL C 372
None
1.21A 2hdnI-5mg5C:
undetectable
2hdnJ-5mg5C:
undetectable
2hdnL-5mg5C:
undetectable
2hdnI-5mg5C:
22.39
2hdnJ-5mg5C:
14.63
2hdnL-5mg5C:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
4 / 6 VAL C 372
THR C 183
SER C 368
ASP C 369
None
1.28A 2hdnJ-5mg5C:
undetectable
2hdnK-5mg5C:
undetectable
2hdnL-5mg5C:
undetectable
2hdnJ-5mg5C:
14.63
2hdnK-5mg5C:
22.39
2hdnL-5mg5C:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 10 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.42A 2hndA-5mg5A:
undetectable
2hndA-5mg5A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 10 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.46A 2hnyA-5mg5A:
undetectable
2hnyA-5mg5A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 TYR C  55
ALA C 348
SER C 349
GLY C 212
TYR C  63
None
None
13X  C 500 (-4.2A)
None
None
1.27A 2igtC-5mg5C:
undetectable
2igtC-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 7 THR A 248
PRO A 249
VAL A 246
SER A 247
None
1.03A 2v2gA-5mg5A:
undetectable
2v2gB-5mg5A:
undetectable
2v2gA-5mg5A:
undetectable
2v2gB-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 7 THR A 248
PRO A 249
VAL A 246
SER A 247
None
1.03A 2v2gA-5mg5A:
undetectable
2v2gB-5mg5A:
undetectable
2v2gA-5mg5A:
undetectable
2v2gB-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 7 THR A 248
PRO A 249
VAL A 246
SER A 247
None
1.03A 2v2gC-5mg5A:
undetectable
2v2gD-5mg5A:
undetectable
2v2gC-5mg5A:
undetectable
2v2gD-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 7 THR A 248
PRO A 249
VAL A 246
SER A 247
None
1.03A 2v2gC-5mg5A:
undetectable
2v2gD-5mg5A:
undetectable
2v2gC-5mg5A:
undetectable
2v2gD-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 7 THR A 248
PRO A 249
VAL A 246
SER A 247
None
1.05A 2v41E-5mg5A:
undetectable
2v41F-5mg5A:
undetectable
2v41E-5mg5A:
undetectable
2v41F-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 7 THR A 248
PRO A 249
VAL A 246
SER A 247
None
1.03A 2v41E-5mg5A:
undetectable
2v41F-5mg5A:
undetectable
2v41E-5mg5A:
undetectable
2v41F-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 8 THR A 248
PRO A 249
VAL A 246
SER A 247
None
1.03A 2v41G-5mg5A:
undetectable
2v41H-5mg5A:
undetectable
2v41G-5mg5A:
undetectable
2v41H-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 VAL C 372
THR C 358
SER C  91
SER C  94
ASN C 382
None
None
None
None
SCY  C  88 ( 3.5A)
1.26A 2y00B-5mg5C:
undetectable
2y00B-5mg5C:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 VAL C 372
THR C 358
SER C  91
SER C  94
ASN C 382
None
None
None
None
SCY  C  88 ( 3.5A)
1.24A 2y01B-5mg5C:
undetectable
2y01B-5mg5C:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 ALA C 147
SER C 131
ALA C  86
GLY C 384
THR C  89
None
None
None
SCY  C  88 ( 3.5A)
SCY  C  88 ( 3.8A)
1.21A 2zifB-5mg5C:
undetectable
2zifB-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 CYH C 112
ALA C  34
MET C  43
ALA C  41
VAL C   9
None
1.26A 3b0wA-5mg5C:
undetectable
3b0wA-5mg5C:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 CYH C 112
ALA C  34
MET C  43
ALA C  41
VAL C   9
None
1.29A 3b0wB-5mg5C:
undetectable
3b0wB-5mg5C:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
3 / 3 TYR C 386
GLU C 309
ASP C 321
None
0.73A 3bxoA-5mg5C:
undetectable
3bxoA-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
3 / 3 TYR C 386
GLU C 309
ASP C 321
None
0.80A 3bxoB-5mg5C:
undetectable
3bxoB-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
4 / 8 GLY C 113
GLY C 114
GLY C 350
SER C  94
None
0.65A 3d41A-5mg5C:
undetectable
3d41A-5mg5C:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 11 LEU A 332
LEU A 282
ALA A  13
ALA A 161
VAL A 272
None
1.05A 3e22B-5mg5A:
undetectable
3e22B-5mg5A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 11 LEU A 332
LEU A 282
ALA A  13
ALA A 161
VAL A 272
None
1.06A 3e22D-5mg5A:
undetectable
3e22D-5mg5A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN
2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens;
Pseudomonas
protegens)
5 / 12 PHE B  42
PRO C 263
GLY C 267
GLY C 249
HIS C 253
None
1.14A 3e23A-5mg5B:
undetectable
3e23A-5mg5B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 9 ASP C 291
GLY C 312
ILE C 313
VAL C 394
ILE C 287
None
1.31A 3ekyB-5mg5C:
undetectable
3ekyB-5mg5C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 10 ARG C 365
ASP C 352
GLY C 114
GLY C 216
ILE C 357
None
1.00A 3em4V-5mg5C:
undetectable
3em4V-5mg5C:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
4 / 6 ILE C 109
TYR C 107
ILE C  76
HIS C  44
None
1.14A 3eteA-5mg5C:
undetectable
3eteE-5mg5C:
undetectable
3eteA-5mg5C:
10.85
3eteE-5mg5C:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
4 / 5 ILE C 109
TYR C 107
ILE C  76
HIS C  44
None
1.15A 3eteB-5mg5C:
undetectable
3eteC-5mg5C:
undetectable
3eteB-5mg5C:
10.85
3eteC-5mg5C:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
4 / 7 ILE C  76
HIS C  44
ILE C 109
TYR C 107
None
1.13A 3eteD-5mg5C:
undetectable
3eteF-5mg5C:
undetectable
3eteD-5mg5C:
10.85
3eteF-5mg5C:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 12 THR A 231
TYR A 238
LEU A 288
SER A 180
ILE A   8
None
1.39A 3frqA-5mg5A:
undetectable
3frqA-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 12 GLY A 276
ASP A 274
ALA A 159
ALA A 161
ALA A 114
None
1.05A 3g8bA-5mg5A:
undetectable
3g8bA-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 12 GLY A 162
ALA A 275
GLY A 283
ILE A 285
VAL A 272
None
1.04A 3gguA-5mg5A:
undetectable
3gguA-5mg5A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
3 / 3 ALA A  62
ARG A  65
LYS A 327
None
0.92A 3kp3B-5mg5A:
undetectable
3kp3B-5mg5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 10 TYR C 298
ASP C 352
LEU C 300
ILE C 128
TYR C 124
SCY  C  88 (-4.2A)
None
None
13X  C 500 (-3.9A)
13X  C 500 (-4.9A)
1.17A 3kz7A-5mg5C:
undetectable
3kz7A-5mg5C:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 9 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.41A 3lp0A-5mg5A:
undetectable
3lp0A-5mg5A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 10 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.45A 3lp1A-5mg5A:
undetectable
3lp1A-5mg5A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 9 ARG C  21
ALA C  73
ASP C  72
ILE C  76
ILE C  30
None
1.11A 3ndwB-5mg5C:
undetectable
3ndwB-5mg5C:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 5 CYH A  83
TYR A 198
PRO A 193
THR A 144
None
1.26A 3q07A-5mg5A:
undetectable
3q07A-5mg5A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 10 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.44A 3qipA-5mg5A:
undetectable
3qipA-5mg5A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
6 / 12 GLY C 340
GLY C 344
LEU C 209
ASN C 342
TYR C 189
ASP C 369
None
1.41A 3sglA-5mg5C:
undetectable
3sglA-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 12 GLY A 115
ASP A 274
GLY A 141
ALA A 278
ALA A 161
None
0.93A 3sudC-5mg5A:
undetectable
3sudC-5mg5A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
6 / 9 GLY A 162
ALA A 275
ASP A 274
GLY A 283
ILE A 285
VAL A 272
None
1.21A 3u7sB-5mg5A:
undetectable
3u7sB-5mg5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
6 / 10 ALA A 175
GLY A   7
LEU A 122
LEU A 313
ASP A 178
ILE A 311
None
1.29A 3wdmB-5mg5A:
undetectable
3wdmB-5mg5A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
6 / 10 ALA A 175
GLY A   7
LEU A 122
LEU A 313
ASP A 178
ILE A 311
None
1.25A 3wdmD-5mg5A:
undetectable
3wdmD-5mg5A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
4 / 7 ILE C  60
GLU C 116
PHE C  26
VAL C  51
None
1.01A 4a97A-5mg5C:
undetectable
4a97A-5mg5C:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
4 / 7 ILE C  60
GLU C 116
PHE C  26
VAL C  51
None
1.02A 4a97D-5mg5C:
undetectable
4a97D-5mg5C:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 6 THR A  57
GLY A  59
ARG A  90
ILE A  96
None
1.02A 4acbC-5mg5A:
undetectable
4acbC-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
4 / 6 THR C  89
HIS C 144
HIS C 246
TYR C 241
SCY  C  88 ( 3.8A)
13X  C 500 (-4.5A)
None
None
1.35A 4df2A-5mg5C:
undetectable
4df2A-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN

(Pseudomonas
protegens)
3 / 3 CYH B  34
ASN B  38
LYS B  57
ZN  B 200 (-2.2A)
None
None
1.30A 4k50A-5mg5B:
undetectable
4k50A-5mg5B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 10 TYR C 298
ASP C 352
LEU C 300
ILE C 128
TYR C 124
SCY  C  88 (-4.2A)
None
None
13X  C 500 (-3.9A)
13X  C 500 (-4.9A)
1.08A 4odoA-5mg5C:
undetectable
4odoA-5mg5C:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 10 TYR C 298
ASP C 352
LEU C 300
ILE C 128
TYR C 124
SCY  C  88 (-4.2A)
None
None
13X  C 500 (-3.9A)
13X  C 500 (-4.9A)
1.06A 4odoC-5mg5C:
undetectable
4odoC-5mg5C:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 9 ALA A 278
TYR A 322
SER A  10
GLY A  12
ALA A  62
None
1.22A 4r1zA-5mg5A:
undetectable
4r1zA-5mg5A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 12 LEU A  58
GLY A 141
ALA A 278
PRO A  16
VAL A 272
None
1.00A 4xdrA-5mg5A:
undetectable
4xdrA-5mg5A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN
2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 11 PHE C 252
ALA B 103
TYR C 386
VAL B 101
GLY C 249
None
1.03A 4xnxA-5mg5C:
undetectable
4xnxA-5mg5C:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 12 ALA A 142
THR A 144
THR A  82
GLY A  14
ALA A 165
None
0.99A 4ypmA-5mg5A:
undetectable
4ypmA-5mg5A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 12 ALA A 142
THR A 144
THR A  82
LEU A  80
ALA A  63
None
1.11A 4ypmA-5mg5A:
undetectable
4ypmA-5mg5A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 12 ALA A 142
THR A 144
THR A  82
LEU A  80
ALA A 165
None
0.80A 4ypmA-5mg5A:
undetectable
4ypmA-5mg5A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
4 / 6 GLY C 341
ASP C 299
GLY C 346
SER C  91
None
1.02A 4z53A-5mg5C:
undetectable
4z53B-5mg5C:
undetectable
4z53A-5mg5C:
7.33
4z53B-5mg5C:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 11 SER A  10
ILE A 174
TYR A 322
PRO A 328
LEU A  67
None
1.45A 5albH-5mg5A:
undetectable
5albH-5mg5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 SER C  91
HIS C 356
GLY C 353
ASP C 339
TYR C  13
None
None
SCY  C  88 ( 4.6A)
None
None
1.42A 5eeiA-5mg5C:
undetectable
5eeiA-5mg5C:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 SER C  91
HIS C 356
GLY C 353
ASP C 339
TYR C  13
None
None
SCY  C  88 ( 4.6A)
None
None
1.42A 5eeiB-5mg5C:
undetectable
5eeiB-5mg5C:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 11 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.40A 5hbmA-5mg5A:
undetectable
5hbmA-5mg5A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 12 ALA A  63
THR A  84
GLN A 112
GLY A  81
SER A 117
None
1.22A 5hfjB-5mg5A:
undetectable
5hfjB-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 12 ILE A 174
LEU A 288
ILE A 168
LEU A 122
GLY A 118
None
1.15A 5ienA-5mg5A:
undetectable
5ienA-5mg5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
3 / 3 ASP A  33
ASN A  27
GLN A  23
None
0.61A 5k7uA-5mg5A:
undetectable
5k7uA-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 11 THR A  57
ALA A 161
GLY A 162
ALA A 142
LEU A 138
None
0.82A 5lf7H-5mg5A:
undetectable
5lf7I-5mg5A:
undetectable
5lf7H-5mg5A:
undetectable
5lf7I-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 11 THR A  57
ALA A 161
GLY A 162
ALA A 142
LEU A 138
None
0.82A 5lf7V-5mg5A:
undetectable
5lf7W-5mg5A:
undetectable
5lf7V-5mg5A:
undetectable
5lf7W-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 ALA C 147
LEU C 150
TYR C 155
ILE C 306
LEU C 169
None
1.25A 5ljcA-5mg5C:
undetectable
5ljcA-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 7 GLY A 162
ASP A 274
ASP A 143
ASN A 146
None
0.94A 5nnwD-5mg5A:
undetectable
5nnwD-5mg5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 7 GLY A 162
ASP A 274
ASP A 143
ASN A 146
None
0.95A 5no9D-5mg5A:
undetectable
5no9D-5mg5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 12 ARG A 220
SER A 301
THR A 119
SER A 277
GLY A 115
None
1.10A 5oj0A-5mg5A:
undetectable
5oj0A-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
4 / 5 ALA C  34
SER C  33
GLY C 216
TYR C  53
None
1.22A 5yodD-5mg5C:
undetectable
5yodD-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 MET C 176
GLY C 346
ALA C 186
TYR C 179
ALA C 210
None
1.07A 5zw4A-5mg5C:
undetectable
5zw4A-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN

(Pseudomonas
protegens)
5 / 9 ASP B  98
ALA B 103
ILE B 102
GLY B  31
PHE B  42
None
1.30A 6awoA-5mg5B:
undetectable
6awoA-5mg5B:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN

(Pseudomonas
protegens)
5 / 9 ASP B  98
ALA B 103
ILE B 102
GLY B  31
PHE B  42
None
1.30A 6awqA-5mg5B:
undetectable
6awqA-5mg5B:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 10 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.36A 6bsgA-5mg5A:
undetectable
6bsgA-5mg5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 10 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.43A 6bsiA-5mg5A:
undetectable
6bsiA-5mg5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
5 / 10 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
None
1.37A 6bsjA-5mg5A:
undetectable
6bsjA-5mg5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens)
4 / 5 ILE A 311
SER A 180
ALA A 121
LEU A 281
None
0.92A 6dwnA-5mg5A:
undetectable
6dwnA-5mg5A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN
2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens)
5 / 12 GLY C 249
VAL B  94
THR C 256
GLY B  49
ASP B  98
None
0.96A 6gngA-5mg5C:
undetectable
6gngA-5mg5C:
9.75