SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCB_P_DHIP3_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-L-GLN-D-PHE
-L-HIS-D-PRO-OH)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
(Schizosaccharomy
ces
pombe) 		4 / 5 TYR A 509
TYR A 440
GLU A 437
GLN A 444
 GOL  A 703 ( 4.8A)
None
None
None
 1.31A 1mcbA-5mg8A:
0.0
1mcbB-5mg8A:
0.0
1mcbP-5mg8A:
undetectable		 1mcbA-5mg8A:
23.06
1mcbB-5mg8A:
23.06
1mcbP-5mg8A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
6
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 ASP A 438
ARG A 486
ARG B 678
 GOL  A 703 (-3.5A)
None
None
 0.98A 3k37A-5mg8A:
undetectable		 3k37A-5mg8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
6
(Schizosaccharomy
ces
pombe) 		5 / 9 ILE B 629
ILE B 646
VAL B 559
TYR B 673
ILE B 571
 None
 1.28A 3p4wA-5mg8B:
undetectable		 3p4wA-5mg8B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
6
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP B 654
ARG B 656
ASP B 676
 None
 0.85A 4fzvA-5mg8B:
undetectable		 4fzvA-5mg8B:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
(Schizosaccharomy
ces
pombe) 		4 / 6 GLU A 616
ARG A 609
ASP A 592
ARG A 587
 None
SO4  A 702 (-3.2A)
None
SO4  A 701 (-3.3A)
 1.35A 4kcnA-5mg8A:
undetectable		 4kcnA-5mg8A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
(Schizosaccharomy
ces
pombe) 		4 / 6 GLU A 616
ARG A 609
ASP A 592
ARG A 587
 None
SO4  A 702 (-3.2A)
None
SO4  A 701 (-3.3A)
 1.34A 4kcnB-5mg8A:
undetectable		 4kcnB-5mg8A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A 547
ARG A 533
TYR A 544
 None
 0.89A 5a7mA-5mg8A:
undetectable		 5a7mA-5mg8A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A 547
ARG A 533
TYR A 544
 None
 0.91A 5a7mB-5mg8A:
undetectable		 5a7mB-5mg8A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
(Schizosaccharomy
ces
pombe) 		3 / 3 THR A 484
HIS A 605
LEU A 624
 None
 0.77A 5axdA-5mg8A:
undetectable		 5axdA-5mg8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
6
(Schizosaccharomy
ces
pombe) 		3 / 3 THR A 597
THR B 602
LEU B 644
 None
 0.66A 5m66D-5mg8A:
undetectable		 5m66D-5mg8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
6
(Schizosaccharomy
ces
pombe) 		5 / 10 ILE B 629
ILE B 646
VAL B 559
TYR B 673
ILE B 571
 None
 1.26A 5mzrA-5mg8B:
undetectable		 5mzrA-5mg8B:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
(Schizosaccharomy
ces
pombe) 		4 / 9 TYR A 598
ILE A 568
ILE A 565
LEU A 549
 None
 0.78A 5vkqB-5mg8A:
undetectable
5vkqC-5mg8A:
undetectable		 5vkqB-5mg8A:
11.53
5vkqC-5mg8A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
(Schizosaccharomy
ces
pombe) 		3 / 3 THR A 484
THR A 487
ARG A 514
 None
 1.08A 5wm2A-5mg8A:
undetectable		 5wm2A-5mg8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 539
ASP A 547
GLY A 543
PHE A 541
 None
 0.89A 5x5qC-5mg8A:
undetectable		 5x5qC-5mg8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE A 539
ASP A 547
GLY A 543
PHE A 541
 None
 0.89A 5x5qD-5mg8A:
undetectable		 5x5qD-5mg8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
6
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU B 590
PHE B 528
GLY B 551
LEU B 640
ILE B 580
 None
 1.28A 5y2tA-5mg8B:
undetectable		 5y2tA-5mg8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
6
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP B 654
ARG B 656
ASP B 676
 None
 0.87A 5zvgA-5mg8B:
undetectable		 5zvgA-5mg8B:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
6
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE B 631
LEU B 626
GLY B 645
GLY B 573
 None
 0.75A 6eu9D-5mg8B:
undetectable		 6eu9D-5mg8B:
17.31