SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mgv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 HIS A 195
LEU A 163
LEU A 128
LEU A  93
 None
 1.01A 1a4lD-5mgvA:
undetectable		 1a4lD-5mgvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ARG A 271
ALA A 268
ASP A 133
GLY A 131
 None
 1.17A 1e7bA-5mgvA:
undetectable		 1e7bA-5mgvA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 277
THR A 210
LEU A 211
LEU A 280
PHE A  61
 None
 1.13A 1mx1C-5mgvA:
undetectable		 1mx1C-5mgvA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 111
ARG A 112
ASP A  91
 None
 0.97A 2qe6A-5mgvA:
undetectable		 2qe6A-5mgvA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 111
ARG A 112
ASP A  91
 None
 0.94A 2qe6B-5mgvA:
undetectable		 2qe6B-5mgvA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ARG A 414
PHE A 333
ILE A 331
PHE A 345
 None
 1.27A 2qeiA-5mgvA:
undetectable		 2qeiA-5mgvA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A 204
GLN A 192
ARG A 187
 None
 0.78A 2w3bB-5mgvA:
undetectable		 2w3bB-5mgvA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 380
ILE A 293
TYR A 152
LEU A 401
 None
 1.12A 3adsA-5mgvA:
undetectable		 3adsA-5mgvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 CYH A 377
HIS A 376
PHE A 333
 None
 1.17A 3cr4X-5mgvA:
undetectable		 3cr4X-5mgvA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 MET A 258
LEU A 262
SER A 238
GLY A 277
 None
 1.07A 3hcnA-5mgvA:
undetectable		 3hcnA-5mgvA:
23.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		12 / 12 SER A 121
GLN A 124
ARG A 143
GLN A 157
GLU A 159
PHE A 232
PHE A 234
THR A 235
GLY A 254
GLY A 256
ALA A 275
GLY A 277
 None
 0.23A 3tegA-5mgvA:
62.1		 3tegA-5mgvA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 9 HIS A 119
SER A 121
ARG A 143
GLN A 157
GLU A 159
ALA A 275
GLY A 277
 None
 0.57A 3tehA-5mgvA:
23.2		 3tehA-5mgvA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 282
GLU A 281
PHE A 296
 None
 0.97A 4kszA-5mgvA:
undetectable		 4kszA-5mgvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 VAL A 394
ALA A 326
ILE A 380
THR A 381
 None
 1.09A 5e4dB-5mgvA:
4.0		 5e4dB-5mgvA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 SER A 121
GLY A 139
VAL A 141
ARG A 143
 None
 0.85A 5fpdA-5mgvA:
undetectable		 5fpdA-5mgvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 TYR A 382
ARG A 350
ILE A 352
GLY A 353
ILE A 397
 None
 1.01A 5ifuA-5mgvA:
9.2		 5ifuA-5mgvA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 SER A 149
ASP A 292
PRO A 291
TYR A 289
 None
 1.24A 5l1fC-5mgvA:
undetectable		 5l1fC-5mgvA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ARG A 302
LEU A 295
PRO A 320
SER A 322
 None
 1.43A 5syjA-5mgvA:
undetectable		 5syjA-5mgvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ARG A 302
LEU A 295
PRO A 320
SER A 322
 None
 1.42A 5syjB-5mgvA:
undetectable		 5syjB-5mgvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 143
HIS A 151
PHE A 155
GLY A 279
ILE A 293
 None
 0.68A 6bniA-5mgvA:
14.3		 6bniA-5mgvA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 143
HIS A 151
PHE A 155
GLY A 279
ILE A 293
 None
 0.70A 6bniB-5mgvA:
14.2		 6bniB-5mgvA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TYR A 346
ASP A 145
GLN A 146
 None
 0.92A 6g1pA-5mgvA:
undetectable		 6g1pA-5mgvA:
23.53