SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mgx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8
(Homo
sapiens) 		5 / 12 LEU E 275
ASN E 276
LEU E 278
ALA E 279
GLN E 282
 None
 0.68A 1ya3C-5mgxE:
undetectable		 1ya3C-5mgxE:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8
(Homo
sapiens) 		5 / 12 LEU E 275
ASN E 276
LEU E 278
ALA E 279
GLN E 282
 None
 0.55A 2aa6A-5mgxE:
undetectable		 2aa6A-5mgxE:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8
(Homo
sapiens) 		5 / 11 VAL E 152
ALA E 230
PRO E 190
LEU E 194
ILE E 153
 None
 1.08A 3clbA-5mgxE:
undetectable		 3clbA-5mgxE:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8
(Homo
sapiens) 		4 / 7 THR E 202
VAL E 122
THR E 124
VAL E 144
 None
 0.61A 3em0B-5mgxE:
undetectable		 3em0B-5mgxE:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8
(Homo
sapiens) 		5 / 10 VAL E 152
ALA E 230
PRO E 190
LEU E 194
ILE E 153
 None
 1.10A 3hbbA-5mgxE:
undetectable		 3hbbA-5mgxE:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8
(Homo
sapiens) 		5 / 11 VAL E 152
ALA E 230
PRO E 190
LEU E 194
ILE E 153
 None
 1.08A 3hbbC-5mgxE:
undetectable		 3hbbC-5mgxE:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8
(Homo
sapiens) 		5 / 12 LEU E 275
ASN E 276
LEU E 278
ALA E 279
GLN E 282
 None
 0.64A 4fn9A-5mgxE:
undetectable		 4fn9A-5mgxE:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8
(Homo
sapiens) 		5 / 12 LEU E 275
ASN E 276
LEU E 278
ALA E 279
GLN E 282
 None
 0.68A 4fn9B-5mgxE:
undetectable		 4fn9B-5mgxE:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8
(Homo
sapiens) 		5 / 12 LEU E 275
ASN E 276
LEU E 278
ALA E 279
GLN E 282
 None
 0.57A 4ltwA-5mgxE:
undetectable		 4ltwA-5mgxE:
21.22