SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		3 / 3 ASP A  70
ASP A  74
ASP A  96
 SAH  A 301 (-2.8A)
None
SAH  A 301 (-3.5A)
 0.70A 1eizA-5mgzA:
10.7		 1eizA-5mgzA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		3 / 3 ASP A  70
ASP A  74
ASP A  96
 SAH  A 301 (-2.8A)
None
SAH  A 301 (-3.5A)
 0.71A 1ej0A-5mgzA:
10.4		 1ej0A-5mgzA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		3 / 4 VAL A 162
TRP A 170
TRP A 161
 None
 1.09A 1gmkA-5mgzA:
undetectable
1gmkB-5mgzA:
undetectable		 1gmkA-5mgzA:
7.26
1gmkB-5mgzA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		5 / 12 ASP A  70
HIS A  15
GLY A  49
GLY A  18
TYR A  25
 SAH  A 301 (-2.8A)
None
SAH  A 301 (-3.4A)
None
SAH  A 301 (-4.5A)
 1.09A 1zz1C-5mgzA:
2.9		 1zz1C-5mgzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		4 / 7 GLY A  49
TYR A  25
ASP A  70
ASP A  96
 SAH  A 301 (-3.4A)
SAH  A 301 (-4.5A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.97A 2g72B-5mgzA:
13.1		 2g72B-5mgzA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		5 / 12 TYR A  25
GLY A  49
SER A  72
ASP A  96
ARG A 116
 SAH  A 301 (-4.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 3.9A)
 0.77A 3dlcA-5mgzA:
20.8		 3dlcA-5mgzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		3 / 3 GLY A  49
ASP A  70
ASP A  96
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.44A 3ou7C-5mgzA:
13.9		 3ou7C-5mgzA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		5 / 12 GLY A  49
LEU A  71
SER A  72
MET A  75
ASP A  96
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.0A)
SAH  A 301 (-3.5A)
 0.45A 3pfgA-5mgzA:
7.5		 3pfgA-5mgzA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		4 / 7 HIS A 120
GLU A  27
PHE A 153
PRO A 219
 ACT  A 303 (-4.0A)
None
None
None
 1.42A 3ql6A-5mgzA:
undetectable		 3ql6A-5mgzA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		5 / 12 CYH A  47
GLY A  51
LEU A  71
SER A  72
ASP A  96
 SAH  A 301 (-3.3A)
None
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
 0.58A 4fp9D-5mgzA:
12.5		 4fp9D-5mgzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		5 / 12 CYH A  47
GLY A  51
LEU A  71
SER A  72
ASP A  96
 SAH  A 301 (-3.3A)
None
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
 0.60A 4fzvA-5mgzA:
11.2		 4fzvA-5mgzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		5 / 12 GLY A  49
LEU A  71
SER A  72
ALA A  97
GLN A  98
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
 0.75A 4htfA-5mgzA:
15.7		 4htfA-5mgzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		5 / 12 GLY A  49
LEU A  71
SER A  72
ALA A  97
GLN A  98
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
 0.70A 4htfB-5mgzA:
15.6		 4htfB-5mgzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		4 / 8 ALA A  21
SER A  22
TYR A  82
TYR A  25
 None
None
None
SAH  A 301 (-4.5A)
 1.22A 4ijiF-5mgzA:
undetectable		 4ijiF-5mgzA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		6 / 12 GLY A  49
ASP A  70
ASP A  96
ARG A 116
ALA A 118
LEU A 122
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 3.9A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.7A)
 0.83A 4iv8A-5mgzA:
17.3		 4iv8A-5mgzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		6 / 12 GLY A  49
ASP A  70
MET A  75
ASP A  96
ARG A 116
ALA A 118
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.0A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 3.9A)
SAH  A 301 (-3.5A)
 0.90A 4iv8A-5mgzA:
17.3		 4iv8A-5mgzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		6 / 12 GLY A  49
ASP A  70
MET A  75
ASP A  96
ARG A 116
ALA A 118
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.0A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 3.9A)
SAH  A 301 (-3.5A)
 0.91A 4iv8B-5mgzA:
17.4		 4iv8B-5mgzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		3 / 3 ARG A 116
ASP A  70
ASP A  96
 SAH  A 301 ( 3.9A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.52A 4kicB-5mgzA:
4.8		 4kicB-5mgzA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		6 / 12 GLY A  49
LEU A  71
SER A  72
ASP A  96
ALA A  97
ARG A 116
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 3.9A)
 0.76A 4krhA-5mgzA:
18.7		 4krhA-5mgzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		5 / 12 GLY A  49
LEU A  71
SER A  72
ALA A  97
ARG A 116
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 3.9A)
 0.66A 4krhB-5mgzA:
18.8		 4krhB-5mgzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		4 / 4 ASP A  45
GLY A  49
ASP A  70
ASP A  96
 SAH  A 301 ( 4.8A)
SAH  A 301 (-3.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.38A 5e72A-5mgzA:
14.6		 5e72A-5mgzA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		5 / 12 GLY A  34
LEU A  66
PHE A  92
GLY A  51
PHE A  61
 None
 1.02A 5fsaB-5mgzA:
undetectable		 5fsaB-5mgzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE
(Streptomyces
niveus) 		5 / 12 TYR A 191
SER A 146
VAL A 221
LEU A 143
PHE A 129
 None
 1.15A 5g6sB-5mgzA:
4.1
5g6sC-5mgzA:
4.0		 5g6sB-5mgzA:
22.73
5g6sC-5mgzA:
22.73