SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mh5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 12 SER A 220
GLY A 246
LEU A 239
VAL A 230
GLU A 232
 None
 1.26A 1a27A-5mh5A:
3.6		 1a27A-5mh5A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		4 / 8 ILE A 244
VAL A 224
ASN A 223
GLY A 246
 None
NAP  A 414 (-4.5A)
None
None
 0.99A 1dzmA-5mh5A:
undetectable		 1dzmA-5mh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 12 ILE A 244
ALA A 245
ARG A 109
LEU A 249
PHE A 212
 None
 1.39A 1y0xX-5mh5A:
undetectable		 1y0xX-5mh5A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		3 / 3 ASP A 181
THR A 197
PRO A 198
 None
NAP  A 414 (-4.4A)
NAP  A 414 (-3.4A)
 0.60A 2q64B-5mh5A:
undetectable		 2q64B-5mh5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 11 LEU A 239
LEU A 235
VAL A 231
ILE A 244
ALA A 208
 None
 1.22A 2q72A-5mh5A:
undetectable		 2q72A-5mh5A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 10 PHE A 252
THR A 272
VAL A 222
VAL A 269
ILE A 271
 None
 1.38A 2qboA-5mh5A:
undetectable		 2qboA-5mh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 11 HIS A  91
ASN A 305
ALA A  15
VAL A 286
LEU A  25
 7N5  A 413 (-3.8A)
None
7N5  A 413 ( 4.6A)
None
None
 1.40A 3jwqB-5mh5A:
undetectable
3jwqC-5mh5A:
undetectable		 3jwqB-5mh5A:
12.92
3jwqC-5mh5A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		3 / 3 ASP A 181
THR A 197
PRO A 198
 None
NAP  A 414 (-4.4A)
NAP  A 414 (-3.4A)
 0.60A 3tkgD-5mh5A:
undetectable		 3tkgD-5mh5A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 12 PHE A 131
ASP A 218
ARG A 216
ALA A 155
ALA A 134
 None
None
None
None
MG  A 404 (-4.7A)
 1.35A 3ua1A-5mh5A:
undetectable		 3ua1A-5mh5A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		4 / 7 THR A  82
VAL A  47
ASP A  45
VAL A  62
 None
 0.87A 4cp4A-5mh5A:
undetectable		 4cp4A-5mh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		4 / 5 VAL A 138
ARG A 137
MET A 159
GLU A 160
 None
 1.46A 4hojA-5mh5A:
undetectable		 4hojA-5mh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 10 TRP A  61
HIS A  63
ILE A 297
LEU A  25
LEU A   6
 None
 1.34A 4jtqA-5mh5A:
undetectable		 4jtqA-5mh5A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		3 / 4 SER A 261
GLY A 227
GLU A  71
 None
 0.62A 4juoA-5mh5A:
undetectable
4juoC-5mh5A:
undetectable		 4juoA-5mh5A:
12.50
4juoC-5mh5A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 12 HIS A  91
ALA A 277
SER A 276
GLY A  68
GLY A 144
 7N5  A 413 (-3.8A)
NAP  A 414 (-3.7A)
NAP  A 414 (-3.3A)
NAP  A 414 ( 3.6A)
NAP  A 414 (-3.2A)
 1.22A 4uilH-5mh5A:
undetectable
4uilL-5mh5A:
undetectable		 4uilH-5mh5A:
undetectable
4uilL-5mh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		4 / 7 LEU A 235
GLU A 204
ILE A 187
VAL A 207
 None
 1.16A 5jh7C-5mh5A:
undetectable		 5jh7C-5mh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 10 ARG A  14
VAL A  12
LEU A  25
GLY A  51
VAL A   8
 None
 1.08A 6eu9B-5mh5A:
undetectable		 6eu9B-5mh5A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		3 / 3 ARG A 191
PHE A 212
PHE A 106
 None
 0.61A 6nknC-5mh5A:
undetectable
6nknJ-5mh5A:
undetectable		 6nknC-5mh5A:
undetectable
6nknJ-5mh5A:
undetectable