SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mhj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		4 / 4 ARG A 336
ALA A 406
ALA A 345
GLU A 365
 None
 1.22A 1e7bA-5mhjA:
undetectable		 1e7bA-5mhjA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		4 / 4 ARG A 336
ALA A 406
ALA A 345
GLU A 365
 None
 1.15A 1e7bB-5mhjA:
undetectable		 1e7bB-5mhjA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		4 / 5 ARG A 336
ALA A 406
ALA A 345
GLU A 365
 None
 1.17A 1e7cA-5mhjA:
undetectable		 1e7cA-5mhjA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 380
GLY A 464
PHE A 465
VAL A 452
ALA A 453
 None
 1.15A 1tlsB-5mhjA:
undetectable		 1tlsB-5mhjA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 380
GLY A 464
PHE A 465
VAL A 452
ALA A 453
 None
 1.16A 1tsnA-5mhjA:
undetectable		 1tsnA-5mhjA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		4 / 8 TYR A 434
TRP A 362
CYH A 407
LEU A 403
 None
 1.42A 1uw6A-5mhjA:
undetectable
1uw6B-5mhjA:
undetectable		 1uw6A-5mhjA:
20.43
1uw6B-5mhjA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		4 / 8 TYR A 434
TRP A 362
CYH A 407
LEU A 403
 None
 1.40A 1uw6D-5mhjA:
undetectable
1uw6E-5mhjA:
undetectable		 1uw6D-5mhjA:
20.43
1uw6E-5mhjA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		4 / 8 TYR A 434
TRP A 362
CYH A 407
LEU A 403
 None
 1.39A 1uw6G-5mhjA:
undetectable
1uw6H-5mhjA:
undetectable		 1uw6G-5mhjA:
20.43
1uw6H-5mhjA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		4 / 8 TYR A 434
TRP A 362
CYH A 407
LEU A 403
 None
 1.45A 1uw6P-5mhjA:
undetectable
1uw6Q-5mhjA:
undetectable		 1uw6P-5mhjA:
20.43
1uw6Q-5mhjA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 380
GLY A 464
PHE A 465
VAL A 452
ALA A 453
 None
 1.16A 2kceA-5mhjA:
undetectable		 2kceA-5mhjA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 380
GLY A 464
PHE A 465
VAL A 452
ALA A 453
 None
 1.20A 2kceB-5mhjA:
undetectable		 2kceB-5mhjA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		5 / 12 GLN A 372
GLY A 367
ARG A 351
ALA A 348
ALA A 345
 None
 0.99A 2oc8A-5mhjA:
undetectable		 2oc8A-5mhjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		5 / 12 GLY A 444
VAL A 425
GLY A 439
ALA A 435
ALA A 319
 None
 1.00A 3sugA-5mhjA:
undetectable		 3sugA-5mhjA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		3 / 3 ARG A 471
TYR A 373
ASN A 482
 None
None
ACY  A 501 (-3.3A)
 0.88A 4ffwB-5mhjA:
undetectable		 4ffwB-5mhjA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4
(Human
alphaherpesvirus
1) 		4 / 5 ALA A 406
ARG A 336
ALA A 342
GLU A 365
 None
 1.21A 5a06C-5mhjA:
undetectable
5a06D-5mhjA:
undetectable		 5a06C-5mhjA:
22.12
5a06D-5mhjA:
22.12