SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mhr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 5mhr 9BG5 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 ASP I  90
LEU I  84
LEU I  86
 None
 0.60A 1ikeA-5mhrI:
undetectable		 1ikeA-5mhrI:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5mhr 9BG5 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 ASP I  90
LEU I  84
LEU I  86
 None
 0.59A 1np1B-5mhrI:
undetectable		 1np1B-5mhrI:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5mhr VIRAL ATTACHMENT
PROTEIN SIGMA 1
(Reovirus
sp.) 		5 / 12 VAL A 430
LEU A 426
TRP A 333
ILE A 350
PHE A 370
 None
 1.50A 1skxA-5mhrA:
undetectable		 1skxA-5mhrA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 5mhr VIRAL ATTACHMENT
PROTEIN SIGMA 1
(Reovirus
sp.) 		4 / 7 VAL A 337
SER A 339
LEU A 368
TRP A 333
 None
 1.19A 3arrA-5mhrA:
undetectable		 3arrA-5mhrA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5mhr VIRAL ATTACHMENT
PROTEIN SIGMA 1
(Reovirus
sp.) 		5 / 10 PHE A 370
ILE A 348
SER A 449
LEU A 426
SER A 339
 None
 1.12A 3o1cA-5mhrA:
undetectable		 3o1cA-5mhrA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5mhr VIRAL ATTACHMENT
PROTEIN SIGMA 1
(Reovirus
sp.) 		5 / 10 PHE A 355
VAL A 324
LEU A 426
LEU A 366
LEU A 428
 None
 1.34A 4zmeB-5mhrA:
1.1		 4zmeB-5mhrA:
20.00