SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mil'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5mil DUTPASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 5 PHE A  41
LEU A 120
MET A  71
LEU A 136
 None
 0.94A 1skxA-5milA:
undetectable		 1skxA-5milA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5mil DUTPASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 5 LEU A  72
LEU A  68
LEU A 128
SER A 127
 None
 0.93A 3vhuA-5milA:
undetectable		 3vhuA-5milA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 5mil DUTPASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		5 / 12 PHE A  41
LEU A  47
PHE A  50
THR A  49
MET A 112
 None
 1.40A 4mubA-5milA:
undetectable		 4mubA-5milA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 5mil DUTPASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		5 / 9 ALA A  79
GLN A   9
LEU A   5
LEU A  14
LEU A  10
 None
 1.42A 4x30A-5milA:
undetectable		 4x30A-5milA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5mil DUTPASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		5 / 10 LEU A  68
TRP A  43
ASN A 135
LEU A 136
LEU A  47
 None
 1.22A 5fhzC-5milA:
undetectable		 5fhzC-5milA:
17.11