SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		5 / 12 PHE C 552
PHE C 345
SER C 489
PHE C 402
VAL C 491
 None
 1.32A 1q23B-5mioC:
undetectable		 1q23B-5mioC:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		5 / 12 SER C 551
PHE C 345
SER C 489
PHE C 402
VAL C 491
 None
 1.30A 1q23B-5mioC:
undetectable		 1q23B-5mioC:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		5 / 12 PHE C 552
PHE C 345
SER C 489
PHE C 402
VAL C 491
 None
 1.29A 1q23C-5mioC:
undetectable		 1q23C-5mioC:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		5 / 12 SER C 551
PHE C 345
SER C 489
PHE C 402
VAL C 491
 None
 1.30A 1q23C-5mioC:
undetectable		 1q23C-5mioC:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		5 / 11 PHE C 552
PHE C 345
SER C 489
PHE C 402
VAL C 491
 None
 1.28A 1q23I-5mioC:
undetectable		 1q23I-5mioC:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		5 / 11 SER C 551
PHE C 345
SER C 489
PHE C 402
VAL C 491
 None
 1.34A 1q23I-5mioC:
undetectable		 1q23I-5mioC:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		5 / 10 SER C 551
PHE C 345
SER C 489
PHE C 402
VAL C 491
 None
 1.35A 1q23K-5mioC:
undetectable		 1q23K-5mioC:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		4 / 4 ASP C 622
LEU C 627
LEU C 628
LEU C 623
 None
 1.34A 1u18A-5mioC:
undetectable		 1u18A-5mioC:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		5 / 12 TYR C 666
ILE C 737
GLY C 700
GLY C 733
ILE C 704
 None
 0.93A 2fk8A-5mioC:
undetectable		 2fk8A-5mioC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		5 / 11 ILE C 671
LEU C 660
HIS C 678
LEU C 676
ALA C 680
 None
 1.08A 4p65E-5mioC:
undetectable
4p65F-5mioC:
undetectable
4p65J-5mioC:
undetectable
4p65L-5mioC:
undetectable		 4p65E-5mioC:
5.60
4p65F-5mioC:
5.69
4p65J-5mioC:
5.69
4p65L-5mioC:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		5 / 12 VAL C 639
LEU C 627
LEU C 660
ILE C 671
ALA C 680
 None
 1.00A 4p65B-5mioC:
undetectable
4p65D-5mioC:
undetectable
4p65I-5mioC:
undetectable
4p65J-5mioC:
undetectable		 4p65B-5mioC:
5.69
4p65D-5mioC:
5.69
4p65I-5mioC:
5.60
4p65J-5mioC:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		5 / 12 THR C 343
SER C 489
GLY C 554
ARG C 549
PHE C 552
 None
 1.08A 4uinH-5mioC:
undetectable
4uinL-5mioC:
undetectable		 4uinH-5mioC:
17.00
4uinL-5mioC:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		4 / 5 LEU C 657
ASP C 686
LEU C 628
THR C 665
 None
 1.19A 4wozF-5mioC:
undetectable
4wozH-5mioC:
undetectable		 4wozF-5mioC:
18.36
4wozH-5mioC:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		3 / 3 MET C 451
ASP C 411
PHE C 402
 None
 0.93A 4xeyA-5mioC:
undetectable		 4xeyA-5mioC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		3 / 3 MET C 451
ASP C 411
PHE C 410
 None
 1.02A 4xeyA-5mioC:
undetectable		 4xeyA-5mioC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		3 / 3 MET C 451
ASP C 411
PHE C 402
 None
 0.95A 4xeyB-5mioC:
undetectable		 4xeyB-5mioC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		3 / 3 MET C 451
ASP C 411
PHE C 410
 None
 0.96A 4xeyB-5mioC:
undetectable		 4xeyB-5mioC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		4 / 6 CYH C 260
CYH C 560
LEU C 332
HIS C 257
 None
 1.14A 5hpuC-5mioC:
undetectable
5hpuD-5mioC:
undetectable		 5hpuC-5mioC:
5.60
5hpuD-5mioC:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		4 / 6 GLY C 351
THR C 350
GLY C 495
ASN C 464
 ANP  C 802 (-3.5A)
ANP  C 802 (-2.5A)
ANP  C 802 (-3.0A)
ANP  C 802 (-3.2A)
 0.81A 5k4pA-5mioC:
undetectable		 5k4pA-5mioC:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		4 / 7 ILE C 449
PHE C 401
ASP C 492
SER C 470
 None
None
MG  C 801 (-2.8A)
None
 1.48A 5nr3A-5mioC:
undetectable		 5nr3A-5mioC:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		5 / 7 GLN C 387
LEU C 383
ASP C 380
ALA C 330
LEU C 332
 None
 1.38A 5nwvA-5mioC:
undetectable		 5nwvA-5mioC:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		4 / 6 PHE C 311
LEU C 576
LEU C 579
ARG C 580
 None
 0.91A 6e43A-5mioC:
undetectable		 6e43A-5mioC:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		4 / 6 PHE C 311
LEU C 576
LEU C 579
ARG C 580
 None
 0.97A 6e43B-5mioC:
undetectable		 6e43B-5mioC:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		4 / 6 PHE C 311
LEU C 576
LEU C 579
ARG C 580
 None
 0.92A 6e43C-5mioC:
undetectable		 6e43C-5mioC:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		4 / 6 PHE C 311
LEU C 576
LEU C 579
ARG C 580
 None
 0.95A 6e43D-5mioC:
undetectable		 6e43D-5mioC:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens) 		4 / 5 ASN C 321
GLY C 351
HIS C 356
ASP C 361
 None
ANP  C 802 (-3.5A)
ANP  C 802 (-3.7A)
ANP  C 802 (-3.6A)
 1.18A 6gh9A-5mioC:
undetectable		 6gh9A-5mioC:
9.48