SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mj7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		5 / 12 ILE A 267
ILE A 256
ALA A  25
ILE A  10
PHE A 205
 None
 1.14A 1bsxA-5mj7A:
undetectable		 1bsxA-5mj7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		5 / 12 ILE A 267
ILE A 256
ALA A  25
ILE A  10
PHE A 205
 None
 1.14A 1bsxB-5mj7A:
undetectable		 1bsxB-5mj7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ALA A 175
VAL A 166
TRP A 202
 None
 1.00A 1c4dA-5mj7A:
undetectable
1c4dB-5mj7A:
undetectable		 1c4dA-5mj7A:
3.98
1c4dB-5mj7A:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		3 / 3 TRP A 202
ALA A 175
VAL A 166
 None
 0.92A 1c4dA-5mj7A:
undetectable
1c4dB-5mj7A:
undetectable		 1c4dA-5mj7A:
3.98
1c4dB-5mj7A:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ALA A 175
VAL A 166
TRP A 202
 None
 0.92A 1c4dC-5mj7A:
undetectable
1c4dD-5mj7A:
undetectable		 1c4dC-5mj7A:
3.98
1c4dD-5mj7A:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ASP A  85
ASP A  94
LYS A 242
 None
 0.90A 1lqtB-5mj7A:
undetectable		 1lqtB-5mj7A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ASP A  85
ASP A  94
LYS A 242
 None
 0.89A 1lquB-5mj7A:
undetectable		 1lquB-5mj7A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		5 / 12 SER A  12
ASP A  11
ASP A  18
ALA A  31
ILE A  33
 None
None
CA  A 401 ( 2.3A)
None
None
 1.25A 1s14B-5mj7A:
undetectable		 1s14B-5mj7A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		5 / 10 ALA A 235
LEU A 228
ARG A  61
LEU A  26
THR A 236
 None
 1.25A 1tdrB-5mj7A:
undetectable		 1tdrB-5mj7A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		4 / 6 GLU A 255
SER A  16
ARG A 240
TYR A 250
 None
 0.93A 1tufA-5mj7A:
undetectable
1tufB-5mj7A:
undetectable		 1tufA-5mj7A:
21.03
1tufB-5mj7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		5 / 10 LEU A  26
ALA A  31
ILE A  33
VAL A 258
ALA A 257
 None
 1.07A 1xp0A-5mj7A:
undetectable		 1xp0A-5mj7A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		5 / 12 ALA A 235
LEU A 228
ARG A  61
LEU A  26
THR A 236
 None
 1.26A 2zzaA-5mj7A:
undetectable		 2zzaA-5mj7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ARG A 286
ASP A 277
ASN A 281
 None
 0.75A 2zzmA-5mj7A:
2.8		 2zzmA-5mj7A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		5 / 12 ASN A 178
GLY A 160
VAL A 200
LEU A 130
ILE A 133
 TRS  A 402 (-3.2A)
None
None
None
CA  A 401 ( 4.7A)
 1.42A 3h52A-5mj7A:
undetectable		 3h52A-5mj7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		4 / 6 ILE A  64
VAL A   9
LEU A 130
ILE A  10
 None
 0.93A 4asdA-5mj7A:
undetectable		 4asdA-5mj7A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		5 / 12 TYR A 224
ALA A 229
ASN A 230
GLU A 244
LEU A 327
 None
 1.09A 4azsA-5mj7A:
3.7		 4azsA-5mj7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		5 / 12 TYR A 224
ALA A 229
ASN A 230
GLU A 244
LEU A 327
 None
 1.13A 4azwA-5mj7A:
undetectable		 4azwA-5mj7A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		4 / 4 GLY A  41
VAL A  45
PHE A  36
ILE A  52
 None
 1.12A 4xv2B-5mj7A:
undetectable		 4xv2B-5mj7A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		4 / 5 ASP A 254
VAL A  39
GLY A  14
ALA A  48
 TRS  A 402 ( 2.5A)
None
None
None
 0.93A 5hwaA-5mj7A:
undetectable		 5hwaA-5mj7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		5 / 12 SER A 237
GLY A  91
GLY A  88
SER A  84
ASP A  13
 None
None
None
None
CA  A 401 (-3.0A)
 1.06A 5kpcB-5mj7A:
2.4		 5kpcB-5mj7A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 5mj7 UNCHARACTERIZED
PROTEIN
(Caenorhabditis
elegans) 		4 / 6 LYS A 313
PHE A 314
VAL A 200
PRO A 201
 None
 1.17A 6fgdA-5mj7A:
2.5		 6fgdA-5mj7A:
21.08