SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mji'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5mji BRAMP DOMAIN PROTEIN
(Streptomyces
davaonensis) 		5 / 10 LEU A   8
ALA A 100
LEU A 104
LEU A 107
LEU A 129
 None
 1.29A 1pcgA-5mjiA:
undetectable		 1pcgA-5mjiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5mji BRAMP DOMAIN PROTEIN
(Streptomyces
davaonensis) 		5 / 10 LEU A   8
ALA A 100
LEU A 104
LEU A 107
LEU A 129
 None
 1.28A 1pcgB-5mjiA:
undetectable		 1pcgB-5mjiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5mji BRAMP DOMAIN PROTEIN
(Streptomyces
davaonensis) 		4 / 4 LEU A 149
PRO A  90
ILE A 103
LEU A 104
 None
7O6  A 301 (-4.2A)
None
None
 1.14A 1ya4C-5mjiA:
undetectable		 1ya4C-5mjiA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5mji BRAMP DOMAIN PROTEIN
(Streptomyces
davaonensis) 		5 / 11 ASP A 136
ASN A  94
THR A 144
GLY A 143
HIS A 140
 None
 1.48A 2hmaA-5mjiA:
undetectable		 2hmaA-5mjiA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 5mji BRAMP DOMAIN PROTEIN
(Streptomyces
davaonensis) 		4 / 7 ILE A  79
ARG A  80
TYR A 154
GLU A 112
 None
 1.14A 2qebB-5mjiA:
undetectable		 2qebB-5mjiA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5mji BRAMP DOMAIN PROTEIN
(Streptomyces
davaonensis) 		5 / 11 LEU A   8
ALA A 100
LEU A 104
LEU A 107
LEU A 129
 None
 1.28A 3uudA-5mjiA:
undetectable		 3uudA-5mjiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5mji BRAMP DOMAIN PROTEIN
(Streptomyces
davaonensis) 		4 / 8 TRP A  72
LEU A  76
ARG A  80
GLU A 112
 None
 1.37A 3zmdA-5mjiA:
undetectable
3zmdB-5mjiA:
undetectable		 3zmdA-5mjiA:
21.79
3zmdB-5mjiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5mji BRAMP DOMAIN PROTEIN
(Streptomyces
davaonensis) 		5 / 9 THR A 196
LEU A 130
VAL A 145
LEU A 149
ILE A  87
 None
 1.26A 4r38C-5mjiA:
undetectable		 4r38C-5mjiA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 5mji BRAMP DOMAIN PROTEIN
(Streptomyces
davaonensis) 		5 / 10 LEU A   8
ALA A 100
LEU A 104
LEU A 107
LEU A 129
 None
 1.30A 5dxeB-5mjiA:
undetectable		 5dxeB-5mjiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5mji BRAMP DOMAIN PROTEIN
(Streptomyces
davaonensis) 		5 / 12 LEU A   8
LEU A 104
LEU A 107
GLY A 150
LEU A 146
 None
 1.07A 5gtrA-5mjiA:
undetectable		 5gtrA-5mjiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5mji BRAMP DOMAIN PROTEIN
(Streptomyces
davaonensis) 		5 / 10 LEU A   8
ALA A 100
LEU A 104
LEU A 107
LEU A 129
 None
 1.31A 5hyrA-5mjiA:
undetectable		 5hyrA-5mjiA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5mji BRAMP DOMAIN PROTEIN
(Streptomyces
davaonensis) 		4 / 6 PRO A 172
GLY A 171
THR A 170
ASN A 134
 None
None
None
7O6  A 301 (-3.4A)
 1.07A 5xxiA-5mjiA:
undetectable		 5xxiA-5mjiA:
19.70