SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mjk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		5 / 10 ALA A 289
ALA A 110
LEU A  33
VAL A  76
ILE A  10
 FAD  A 401 (-3.6A)
None
None
None
None
 1.31A 1claA-5mjkA:
undetectable		 1claA-5mjkA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q72_H_COCH401_1
(FAB M82G2, HEAVY
CHAIN
FAB M82G2, LIGHT
CHAIN)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		5 / 10 VAL A 170
GLN A 145
GLY A 167
TYR A 162
TYR A 237
 None
 1.18A 1q72H-5mjkA:
undetectable
1q72L-5mjkA:
undetectable		 1q72H-5mjkA:
19.69
1q72L-5mjkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		4 / 8 GLY A  12
THR A  19
ALA A  20
ALA A  21
 FAD  A 401 (-3.3A)
None
None
None
 0.51A 2ej3A-5mjkA:
undetectable		 2ej3A-5mjkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		4 / 6 PRO A  39
GLY A  14
ILE A  10
GLY A  12
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 (-3.3A)
 0.83A 2jkjA-5mjkA:
undetectable		 2jkjA-5mjkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		4 / 6 PRO A  39
GLY A  14
ILE A  10
GLY A  12
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 (-3.3A)
 0.83A 2jkjB-5mjkA:
undetectable		 2jkjB-5mjkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		4 / 6 PRO A  39
GLY A  14
ILE A  10
GLY A  12
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 (-3.3A)
 0.84A 2jkjC-5mjkA:
undetectable		 2jkjC-5mjkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		4 / 7 PRO A  39
GLY A  14
ILE A  10
GLY A  12
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 (-3.3A)
 0.84A 2jklA-5mjkA:
undetectable		 2jklA-5mjkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		4 / 6 PRO A  39
GLY A  14
ILE A  10
GLY A  12
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 (-3.3A)
 0.85A 2jklB-5mjkA:
undetectable		 2jklB-5mjkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		4 / 7 PRO A  39
GLY A  14
ILE A  10
GLY A  12
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 (-3.3A)
 0.88A 2jklC-5mjkA:
undetectable		 2jklC-5mjkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		4 / 7 PRO A  39
GLY A  14
ILE A  10
GLY A  12
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 (-3.3A)
 0.86A 2jklD-5mjkA:
undetectable		 2jklD-5mjkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		4 / 7 PRO A  39
GLY A  14
ILE A  10
GLY A  12
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 (-3.3A)
 0.85A 2jklF-5mjkA:
undetectable		 2jklF-5mjkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		5 / 11 ALA A 110
GLY A 291
THR A 288
ALA A 289
ASP A 277
 None
None
None
FAD  A 401 (-3.6A)
FAD  A 401 (-2.9A)
 1.15A 3mg0V-5mjkA:
undetectable
3mg0W-5mjkA:
undetectable		 3mg0V-5mjkA:
19.76
3mg0W-5mjkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		5 / 9 LEU A  34
ILE A  11
ILE A  10
TYR A  23
ILE A 107
 None
 1.10A 3zosA-5mjkA:
undetectable		 3zosA-5mjkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		5 / 11 ILE A 272
ILE A 252
GLY A 251
VAL A 278
ARG A  36
 None
None
None
None
FAD  A 401 (-3.6A)
 0.87A 4ac9B-5mjkA:
undetectable
4ac9C-5mjkA:
undetectable		 4ac9B-5mjkA:
23.12
4ac9C-5mjkA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 5mjk THIOREDOXIN
REDUCTASE
(Lactococcus
lactis) 		4 / 7 ILE A 259
ALA A 274
VAL A 275
ALA A 244
 None
 0.70A 4g77A-5mjkA:
undetectable		 4g77A-5mjkA:
20.97