SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mjr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		5 / 12 ALA A 162
LEU A 139
ILE A 109
LEU A 122
PRO A 121
 None
 1.02A 1rx8A-5mjrA:
undetectable		 1rx8A-5mjrA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		5 / 12 ASN A 114
SER A 115
ASP A 111
GLU A 112
ILE A 165
 None
 1.23A 1s14B-5mjrA:
undetectable		 1s14B-5mjrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		4 / 5 VAL A  56
GLY A  55
VAL A  57
TRP A  98
 None
 1.30A 1tkqB-5mjrA:
undetectable		 1tkqB-5mjrA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		5 / 12 LEU A  40
HIS A 127
LEU A 167
PRO A 168
VAL A 172
 None
 1.26A 2po7B-5mjrA:
undetectable		 2po7B-5mjrA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		5 / 12 LEU A  40
HIS A 127
LEU A 167
PRO A 168
VAL A 172
 None
 1.38A 2qd4A-5mjrA:
undetectable		 2qd4A-5mjrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		5 / 12 LEU A  40
HIS A 127
LEU A 167
PRO A 168
VAL A 172
 None
 1.23A 2qd4B-5mjrA:
undetectable		 2qd4B-5mjrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		5 / 10 ILE A  76
PHE A  63
TYR A  15
LEU A  34
LEU A  33
 None
 1.15A 2w98A-5mjrA:
undetectable		 2w98A-5mjrA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		5 / 12 THR A 157
ILE A 165
ILE A 169
GLU A 170
PRO A 163
 None
 1.26A 2yzqA-5mjrA:
undetectable		 2yzqA-5mjrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		5 / 12 PHE A 142
LEU A 139
PRO A 121
LEU A 167
THR A 157
 None
 0.99A 3nrrA-5mjrA:
undetectable		 3nrrA-5mjrA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		5 / 12 PHE A 142
LEU A 139
PRO A 121
LEU A 167
THR A 157
 None
 1.04A 3nrrB-5mjrA:
undetectable		 3nrrB-5mjrA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		5 / 10 ALA A  53
GLY A  55
LEU A  80
LEU A 134
ILE A  37
 None
 1.16A 3wdmD-5mjrA:
undetectable		 3wdmD-5mjrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		4 / 8 THR A 151
LEU A 154
THR A 157
LEU A 158
 None
 0.72A 4z90F-5mjrA:
2.7
4z90G-5mjrA:
2.6
4z90H-5mjrA:
2.4
4z90I-5mjrA:
2.4
4z90J-5mjrA:
2.6		 4z90F-5mjrA:
22.09
4z90G-5mjrA:
22.09
4z90H-5mjrA:
22.09
4z90I-5mjrA:
22.09
4z90J-5mjrA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5mjr PROTEIN THF1
(Thermosynechococ
cus
elongatus) 		4 / 8 THR A 157
LEU A 158
THR A 151
LEU A 154
 None
 0.66A 4z90F-5mjrA:
2.7
4z90G-5mjrA:
2.6
4z90H-5mjrA:
2.4
4z90I-5mjrA:
2.4
4z90J-5mjrA:
2.6		 4z90F-5mjrA:
22.09
4z90G-5mjrA:
22.09
4z90H-5mjrA:
22.09
4z90I-5mjrA:
22.09
4z90J-5mjrA:
22.09