SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mkc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5mkc CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN (JO),CELL
WALL SURFACE ANCHOR
FAMILY PROTEIN (IN)
(Streptococcus
pneumoniae) 		5 / 10 PHE A 713
PRO A 714
ILE A 661
TYR A 678
PRO A 716
 None
 1.43A 13gsA-5mkcA:
undetectable		 13gsA-5mkcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 5mkc CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN (JO),CELL
WALL SURFACE ANCHOR
FAMILY PROTEIN (IN)
(Streptococcus
pneumoniae) 		5 / 9 PHE A 713
PRO A 714
ILE A 661
TYR A 678
PRO A 716
 None
 1.43A 13gsB-5mkcA:
undetectable		 13gsB-5mkcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5mkc CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN (JO),CELL
WALL SURFACE ANCHOR
FAMILY PROTEIN (IN)
(Streptococcus
pneumoniae) 		3 / 3 TYR A 145
HIS A 172
ARG A 719
 None
 1.04A 4e7bC-5mkcA:
undetectable		 4e7bC-5mkcA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 5mkc CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN (JO),CELL
WALL SURFACE ANCHOR
FAMILY PROTEIN (IN)
(Streptococcus
pneumoniae) 		4 / 7 TYR A 204
ILE A 193
ILE A 206
ILE A 715
 None
 0.94A 5murB-5mkcA:
2.7		 5murB-5mkcA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5mkc CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN (JO),CELL
WALL SURFACE ANCHOR
FAMILY PROTEIN (IN)
(Streptococcus
pneumoniae) 		5 / 10 ILE A 193
ILE A 206
LEU A 208
ILE A 160
ASN A 178
 None
 1.13A 5vkqA-5mkcA:
undetectable
5vkqD-5mkcA:
undetectable		 5vkqA-5mkcA:
9.19
5vkqD-5mkcA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5mkc CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN (JO),CELL
WALL SURFACE ANCHOR
FAMILY PROTEIN (IN)
(Streptococcus
pneumoniae) 		5 / 10 ILE A 160
ASN A 178
ILE A 193
ILE A 206
LEU A 208
 None
 1.14A 5vkqA-5mkcA:
undetectable
5vkqB-5mkcA:
undetectable		 5vkqA-5mkcA:
9.19
5vkqB-5mkcA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5mkc CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN (JO),CELL
WALL SURFACE ANCHOR
FAMILY PROTEIN (IN)
(Streptococcus
pneumoniae) 		5 / 10 ILE A 160
ASN A 178
ILE A 193
ILE A 206
LEU A 208
 None
 1.12A 5vkqC-5mkcA:
undetectable
5vkqD-5mkcA:
undetectable		 5vkqC-5mkcA:
9.19
5vkqD-5mkcA:
9.19