SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mkf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		4 / 7 ILE A 639
PHE A 626
ASN A 645
ILE A 649
 None
 0.97A 1yc2E-5mkfA:
undetectable		 1yc2E-5mkfA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		5 / 11 TYR A 660
GLU A 648
VAL A 623
PHE A 619
ILE A 633
 None
 1.21A 2dg4A-5mkfA:
undetectable		 2dg4A-5mkfA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		5 / 12 LEU A 415
ILE A 424
VAL A 443
THR A 283
LEU A 409
 None
 1.14A 2japA-5mkfA:
undetectable		 2japA-5mkfA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		5 / 12 LEU A 415
ILE A 424
VAL A 443
THR A 283
LEU A 409
 None
 1.18A 2japB-5mkfA:
undetectable		 2japB-5mkfA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		5 / 12 LEU A 415
ILE A 424
VAL A 443
THR A 283
LEU A 409
 None
 1.12A 2japC-5mkfA:
undetectable		 2japC-5mkfA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		5 / 12 LEU A 415
ILE A 424
VAL A 443
THR A 283
LEU A 409
 None
 1.15A 2japD-5mkfA:
undetectable		 2japD-5mkfA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		3 / 3 PHE A 637
PHE A 608
PHE A 605
 None
None
PLM  A1009 ( 4.6A)
 0.88A 2od9A-5mkfA:
undetectable		 2od9A-5mkfA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		3 / 3 PHE A 637
PHE A 608
PHE A 605
 None
None
PLM  A1009 ( 4.6A)
 0.88A 2qqgA-5mkfA:
undetectable		 2qqgA-5mkfA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		3 / 3 LYS A 461
ILE A 479
PHE A 483
 None
 0.93A 3j7zS-5mkfA:
undetectable
3j7za-5mkfA:
undetectable		 3j7zS-5mkfA:
7.93
3j7za-5mkfA:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		4 / 8 LEU A 288
ALA A 403
TYR A 292
SER A 396
 None
 1.10A 3rodA-5mkfA:
undetectable		 3rodA-5mkfA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		4 / 6 GLU A 284
ASP A 278
ASP A 289
GLU A 266
 None
 1.30A 3vywA-5mkfA:
undetectable		 3vywA-5mkfA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_1
(MNMC2)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		4 / 4 GLU A 284
ASP A 278
ASP A 289
GLU A 266
 None
 1.29A 3vywB-5mkfA:
undetectable		 3vywB-5mkfA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		4 / 5 GLU A 284
ASP A 278
ASP A 289
GLU A 266
 None
 1.30A 3vywD-5mkfA:
undetectable		 3vywD-5mkfA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MFL_B_GCSB502_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		4 / 6 GLN A 323
TRP A 280
TRP A 414
ALA A 365
 None
 1.38A 4mflA-5mkfA:
undetectable		 4mflA-5mkfA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MFQ_B_GCSB503_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		4 / 6 GLN A 323
TRP A 280
TRP A 414
ALA A 365
 None
 1.39A 4mfqA-5mkfA:
0.0		 4mfqA-5mkfA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		4 / 5 SER A 351
SER A 352
SER A 349
SER A 330
 None
 1.47A 5hswA-5mkfA:
undetectable		 5hswA-5mkfA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		5 / 9 ALA A 474
ILE A 478
GLU A 477
TYR A 465
ILE A 526
 None
 0.85A 5mvmA-5mkfA:
4.4
5mvmE-5mkfA:
4.7		 5mvmA-5mkfA:
6.26
5mvmE-5mkfA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		5 / 10 ILE A 526
ALA A 474
ILE A 478
GLU A 477
TYR A 465
 None
 1.02A 5mvmD-5mkfA:
4.4
5mvmE-5mkfA:
4.7		 5mvmD-5mkfA:
6.26
5mvmE-5mkfA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		4 / 7 ARG A 440
LEU A 442
ALA A 421
ILE A 321
 None
 0.99A 5te8A-5mkfA:
undetectable		 5te8A-5mkfA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		4 / 8 TYR A 227
PHE A 230
PHE A 480
VAL A 515
 None
 1.23A 6huoC-5mkfA:
4.5
6huoD-5mkfA:
3.8		 6huoC-5mkfA:
5.51
6huoD-5mkfA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		5 / 12 PRO A 453
VAL A 451
TYR A 386
THR A 419
PHE A 279
 None
 1.38A 6j20A-5mkfA:
5.1		 6j20A-5mkfA:
16.88