SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mkt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5mkt RENIN-1
(Mus
musculus) 		4 / 8 SER A 221
ILE A 375
PHE A 368
SER A 269
 None
 1.15A 1kb9A-5mktA:
undetectable
1kb9C-5mktA:
undetectable
1kb9D-5mktA:
undetectable
1kb9E-5mktA:
undetectable		 1kb9A-5mktA:
undetectable
1kb9C-5mktA:
undetectable
1kb9D-5mktA:
undetectable
1kb9E-5mktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 5mkt RENIN-1
(Mus
musculus) 		4 / 4 SER A 236
ILE A 235
VAL A 265
THR A  56
 None
 1.25A 1u70A-5mktA:
undetectable		 1u70A-5mktA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZWP_A_NIMA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5mkt RENIN-1
(Mus
musculus) 		4 / 5 LEU A 171
GLY A 174
TRP A 241
ASP A 188
 None
 1.45A 1zwpA-5mktA:
undetectable		 1zwpA-5mktA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 5mkt RENIN-1
(Mus
musculus) 		5 / 12 LEU A  87
VAL A 147
GLY A 144
GLY A 143
ILE A  11
 None
 1.02A 2r5pA-5mktA:
8.2		 2r5pA-5mktA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 5mkt RENIN-1
(Mus
musculus) 		5 / 12 LEU A  87
VAL A 147
GLY A 144
GLY A 143
ILE A  11
 None
 1.02A 2r5pC-5mktA:
8.2		 2r5pC-5mktA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 5mkt RENIN-1
(Mus
musculus) 		4 / 7 ILE A  11
THR A 366
ILE A  67
GLY A 268
 None
 0.95A 2v0mB-5mktA:
undetectable		 2v0mB-5mktA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 5mkt RENIN-1
(Mus
musculus) 		8 / 12 ASP A  81
GLY A  83
SER A  84
PRO A 161
PHE A 167
VAL A 170
ASP A 266
GLY A 268
 None
 0.63A 2v0zC-5mktA:
39.6		 2v0zC-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 5mkt RENIN-1
(Mus
musculus) 		7 / 12 ASP A  81
GLY A  83
SER A  84
VAL A 170
ASP A 266
GLY A 268
SER A 270
 None
 0.60A 2v0zC-5mktA:
39.6		 2v0zC-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 5mkt RENIN-1
(Mus
musculus) 		7 / 12 VAL A 264
ASP A 266
GLY A 268
SER A 269
VAL A 355
ASP A  81
GLY A  83
 None
 0.67A 2v0zC-5mktA:
39.6		 2v0zC-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 5mkt RENIN-1
(Mus
musculus) 		5 / 12 ASP A  81
ALA A 165
PHE A 167
VAL A 170
GLY A 268
 None
 0.75A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 5mkt RENIN-1
(Mus
musculus) 		6 / 12 ASP A  81
GLY A  83
PHE A 167
VAL A 170
ASP A 266
GLY A 268
 None
 0.55A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 5mkt RENIN-1
(Mus
musculus) 		6 / 12 ASP A  81
GLY A  83
VAL A 170
ASP A 266
GLY A 268
SER A 270
 None
 0.55A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 5mkt RENIN-1
(Mus
musculus) 		6 / 12 ASP A  81
GLY A 268
VAL A 170
ASP A 266
GLY A  83
ILE A 361
 None
 1.49A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 5mkt RENIN-1
(Mus
musculus) 		6 / 12 VAL A 264
ASP A 266
GLY A 268
VAL A 355
ASP A  81
GLY A  83
 None
 0.64A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5mkt RENIN-1
(Mus
musculus) 		4 / 8 SER A 310
THR A 319
LEU A 379
THR A 254
 None
 1.04A 2v0zO-5mktA:
39.8		 2v0zO-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5mkt RENIN-1
(Mus
musculus) 		5 / 12 ASP A  81
GLY A  83
ASP A 266
SER A 270
SER A 273
 None
 0.70A 3d91A-5mktA:
40.0		 3d91A-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5mkt RENIN-1
(Mus
musculus) 		5 / 12 ASP A  81
GLY A  83
PHE A 167
ASP A 266
SER A 273
 None
 0.74A 3d91A-5mktA:
40.0		 3d91A-5mktA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 5mkt RENIN-1
(Mus
musculus) 		4 / 8 GLY A  83
SER A  84
ILE A 124
ASP A 266
 None
 0.50A 3pwwA-5mktA:
32.0		 3pwwA-5mktA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 5mkt RENIN-1
(Mus
musculus) 		5 / 12 ILE A  79
ASP A  81
GLY A  83
ILE A 124
ASP A 266
 None
 0.53A 3tneA-5mktA:
31.0		 3tneA-5mktA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 5mkt RENIN-1
(Mus
musculus) 		5 / 12 ILE A  79
ASP A  81
GLY A  83
ILE A 124
ASP A 266
 None
 0.52A 3tneB-5mktA:
30.9		 3tneB-5mktA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5mkt RENIN-1
(Mus
musculus) 		5 / 12 TYR A  58
GLY A 172
GLY A  83
ILE A  79
ALA A 179
 None
 1.14A 4a6dA-5mktA:
undetectable		 4a6dA-5mktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mkt RENIN-1
(Mus
musculus) 		4 / 6 PHE A  80
MET A 173
ILE A  11
VAL A 140
 None
 1.08A 4mk4B-5mktA:
undetectable		 4mk4B-5mktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 5mkt RENIN-1
(Mus
musculus) 		3 / 3 ASP A 266
ASP A  81
ASN A  86
 None
 0.80A 4q5mA-5mktA:
9.1		 4q5mA-5mktA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5mkt RENIN-1
(Mus
musculus) 		4 / 5 ILE A  67
ILE A 190
HIS A 189
VAL A 186
 None
 1.02A 5jmnA-5mktA:
undetectable		 5jmnA-5mktA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5mkt RENIN-1
(Mus
musculus) 		5 / 12 ALA A 262
GLY A 351
ILE A 243
ASP A 312
GLY A 247
 None
 1.24A 5wwsB-5mktA:
undetectable		 5wwsB-5mktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 5mkt RENIN-1
(Mus
musculus) 		4 / 7 GLY A 182
ASN A 118
GLU A 153
GLY A 152
 None
NAG  A 401 (-1.9A)
None
None
 0.95A 6n7fA-5mktA:
undetectable		 6n7fA-5mktA:
20.88