SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ml0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		3 / 4 LYS A 739
ALA A 744
MET A 748
 None
 0.97A 1hk3A-5ml0A:
2.1		 1hk3A-5ml0A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		3 / 3 ARG A 779
TYR A 728
LYS A 732
 None
 0.87A 1uujB-5ml0A:
undetectable		 1uujB-5ml0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		4 / 8 TRP A 745
PRO A 746
VAL A 751
ASN A 802
 None
P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 (-3.2A)
 0.63A 3u5kA-5ml0A:
15.8		 3u5kA-5ml0A:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		4 / 7 TRP A 745
PRO A 746
VAL A 751
ASN A 802
 None
P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 (-3.2A)
 0.56A 3u5kB-5ml0A:
15.7		 3u5kB-5ml0A:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		4 / 8 TRP A 745
PRO A 746
VAL A 751
ASN A 802
 None
P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 (-3.2A)
 0.67A 3u5kD-5ml0A:
15.9		 3u5kD-5ml0A:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		5 / 12 LEU A 731
ASN A 733
ALA A 744
PHE A 819
LEU A 815
 None
 1.11A 3vywC-5ml0A:
undetectable		 3vywC-5ml0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		4 / 6 PRO A 746
VAL A 751
TYR A 759
ASN A 802
 P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 ( 4.6A)
P2L  A 901 (-3.2A)
 0.40A 5pbeA-5ml0A:
18.3		 5pbeA-5ml0A:
26.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B
(Mus
musculus) 		5 / 8 PRO A 746
VAL A 751
CYH A 798
TYR A 801
ASN A 802
 P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 ( 3.8A)
P2L  A 901 (-4.1A)
P2L  A 901 (-3.2A)
 0.83A 5y1yA-5ml0A:
15.7		 5y1yA-5ml0A:
32.99