SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5mlc 50S RIBOSOMAL
PROTEIN L13,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 LEU L 217
TYR L 216
HIS L 220
THR L 144
 None
G  A   8 ( 4.9A)
None
None
 1.10A 1afsA-5mlcL:
undetectable		 1afsA-5mlcL:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5mlc 50S RIBOSOMAL
PROTEIN L13,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 LEU L 217
TYR L 216
HIS L 220
THR L 144
 None
G  A   8 ( 4.9A)
None
None
 1.09A 1afsB-5mlcL:
undetectable		 1afsB-5mlcL:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		5 / 12 LEU Z  92
ILE V 147
LEU Z 152
PRO Z 149
VAL Z 146
 None
 1.05A 1hrkA-5mlcZ:
undetectable		 1hrkA-5mlcZ:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 5mlc 50S RIBOSOMAL
PROTEIN L27,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 9 ILE X  93
PHE X 125
GLY X  83
ILE X  81
ALA X  91
 None
G  A 867 ( 4.0A)
G  A 866 ( 3.1A)
None
A  A2371 ( 4.0A)
 1.23A 1mrgA-5mlcX:
undetectable		 1mrgA-5mlcX:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5mlc 50S RIBOSOMAL
PROTEIN L13,
CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 LEU L 140
HIS L 134
ILE L 133
 None
 0.68A 1s9pB-5mlcL:
undetectable		 1s9pB-5mlcL:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5mlc 50S RIBOSOMAL
PROTEIN L27,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 10 GLY X 104
VAL X 107
GLY X 108
VAL X 135
HIS X 113
 None
None
None
None
U  A2403 ( 4.5A)
 1.33A 1v3qE-5mlcX:
undetectable		 1v3qE-5mlcX:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 LEU V 187
LEU V 178
ILE V 176
SER V 152
ILE V 151
 None
 1.03A 2bxqA-5mlcV:
undetectable		 2bxqA-5mlcV:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		4 / 5 LEU V 115
PHE V 155
VAL Z 146
ALA V 150
 None
 1.08A 2cizA-5mlcV:
undetectable		 2cizA-5mlcV:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		5 / 12 LEU Z  92
ILE V 147
LEU Z 152
PRO Z 149
VAL Z 146
 None
 1.11A 2hrcA-5mlcZ:
undetectable		 2hrcA-5mlcZ:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		5 / 12 LEU Z  92
ILE V 147
LEU Z 152
PRO Z 149
VAL Z 146
 None
 1.12A 2hrcB-5mlcZ:
undetectable		 2hrcB-5mlcZ:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5mlc 50S RIBOSOMAL
PROTEIN L18,
CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 ASP Q 142
ARG Q  70
ARG Q  72
 None
A  A2395 ( 2.8A)
G  B  10 ( 3.5A)
 1.07A 2j9dA-5mlcQ:
undetectable
2j9dC-5mlcQ:
undetectable		 2j9dA-5mlcQ:
20.22
2j9dC-5mlcQ:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 5mlc 50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 ARG Z 109
GLY Z 106
PRO Z 102
LYS Z 101
 A  A  59 ( 3.0A)
None
A  A  94 ( 3.7A)
None
 1.22A 2m2oB-5mlcZ:
undetectable		 2m2oB-5mlcZ:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		5 / 12 LEU Z  92
ILE V 147
LEU Z 152
PRO Z 149
VAL Z 146
 None
 1.14A 2po5A-5mlcZ:
undetectable		 2po5A-5mlcZ:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		5 / 12 LEU Z  92
ILE V 147
LEU Z 152
PRO Z 149
VAL Z 146
 None
 1.14A 2po7A-5mlcZ:
undetectable		 2po7A-5mlcZ:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 5mlc 50S RIBOSOMAL
PROTEIN L3,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 8 ASN E 301
LYS E 296
PRO E 294
PHE E 191
 None
C  A2789 ( 2.7A)
None
None
 1.46A 3bjwD-5mlcE:
undetectable		 3bjwD-5mlcE:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5mlc 50S RIBOSOMAL
PROTEIN L27,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 ILE X  92
PHE X 125
PHE X 101
GLY X 110
 A  A2371 ( 3.9A)
G  A 867 ( 4.0A)
G  A 867 ( 4.6A)
G  A2382 ( 3.9A)
 1.12A 3em0B-5mlcX:
undetectable		 3em0B-5mlcX:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 5mlc 50S RIBOSOMAL
PROTEIN L3,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 10 GLU E 142
LEU E 149
LEU E 144
HIS E 156
LEU E 157
 None
None
None
C  A2803 ( 3.7A)
None
 1.46A 3erdB-5mlcE:
undetectable		 3erdB-5mlcE:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 ALA V 174
LEU V 115
GLN V 113
ILE V 191
LEU Z  92
 None
 1.28A 3ia4A-5mlcV:
undetectable		 3ia4A-5mlcV:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 ALA V 174
LEU V 115
GLN V 113
ILE V 191
LEU Z  92
 None
 1.25A 3ia4C-5mlcV:
undetectable		 3ia4C-5mlcV:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 5mlc 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 ILE R 143
GLU R 135
ASN R 174
VAL R 131
VAL R 140
 None
None
G  C  47 ( 4.1A)
None
None
 1.34A 3qwuB-5mlcR:
undetectable		 3qwuB-5mlcR:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 5mlc 50S RIBOSOMAL
PROTEIN L28,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 9 LEU Y 145
ASP Y 144
ALA Y 138
ILE Y 129
GLY Y 133
 A  A 149 ( 3.6A)
None
None
None
None
 1.11A 3u7sA-5mlcY:
undetectable		 3u7sA-5mlcY:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5mlc 50S RIBOSOMAL
PROTEIN L15,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 4 ILE N 200
LEU N 198
LYS N 199
ASN N 161
 None
None
G  A 648 ( 2.7A)
A  A 639 ( 2.8A)
 1.43A 4g19D-5mlcN:
undetectable		 4g19D-5mlcN:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5mlc 50S RIBOSOMAL
PROTEIN L21,
CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 LYS T 199
TYR T 206
ARG T 208
 C  A1020 ( 3.3A)
G  A1208 ( 4.0A)
C  A 826 ( 3.8A)
 1.37A 4gc9A-5mlcT:
undetectable		 4gc9A-5mlcT:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 5mlc 50S RIBOSOMAL
PROTEIN L21,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 9 VAL T 186
ILE T 219
ARG T 218
ILE T 156
GLY T 130
 None
None
None
None
U  A1188 ( 3.3A)
 1.05A 4kukA-5mlcT:
undetectable		 4kukA-5mlcT:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5mlc 50S RIBOSOMAL
PROTEIN L27,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 ASP X  84
GLU X 126
VAL X 107
ALA X 117
 A  A 865 ( 4.6A)
None
None
None
 1.08A 4nkvC-5mlcX:
undetectable		 4nkvC-5mlcX:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5mlc 50S RIBOSOMAL
PROTEIN L13,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 PHE L 188
LEU L 239
THR L 130
ILE L 131
ILE L 200
 None
 1.27A 5ifuA-5mlcL:
undetectable		 5ifuA-5mlcL:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5mlc 50S RIBOSOMAL
PROTEIN L15,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 ALA N 214
VAL N 176
PHE N 217
ILE N 165
 None
 0.81A 5of1A-5mlcN:
undetectable		 5of1A-5mlcN:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5mlc 50S RIBOSOMAL
PROTEIN L15,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 ALA N 214
VAL N 176
PHE N 217
ILE N 165
 None
 0.78A 5of1B-5mlcN:
undetectable		 5of1B-5mlcN:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5mlc 50S RIBOSOMAL
PROTEIN L27,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 8 GLY X  83
ARG X 140
GLN X 143
TYR X 138
 G  A 866 ( 3.1A)
None
None
None
 1.02A 5vlmA-5mlcX:
undetectable		 5vlmA-5mlcX:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 5mlc 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 10 ALA R 130
GLY R 176
THR R 179
ILE R 177
ALA R 134
 None
 1.26A 5vyhA-5mlcR:
undetectable		 5vyhA-5mlcR:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5mlc 50S RIBOSOMAL
PROTEIN L3,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 VAL E 139
VAL E 162
GLY E 120
TYR E 141
 None
 0.96A 5x80C-5mlcE:
undetectable
5x80D-5mlcE:
undetectable		 5x80C-5mlcE:
18.89
5x80D-5mlcE:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5mlc 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 ARG R 182
ILE R 170
SER R 171
 G  A2702 ( 3.6A)
None
None
 0.79A 5zw2A-5mlcR:
undetectable		 5zw2A-5mlcR:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 ARG V 106
ARG V 107
ASP V 143
 None
C  A 127 ( 3.3A)
None
 0.90A 6d8pA-5mlcV:
undetectable		 6d8pA-5mlcV:
13.74