SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mlh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5mlh -
(-) 		5 / 12 CYH A 250
PHE A 375
SER A 371
GLY A 239
LEU A 310
 None
 1.26A 2lbdA-5mlhA:
undetectable		 2lbdA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5mlh -
(-) 		3 / 3 GLU A 112
VAL A 113
CYH A 116
 None
 1.00A 3fbxA-5mlhA:
undetectable		 3fbxA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 5mlh -
(-) 		4 / 5 GLN A 182
THR A 181
GLU A 112
THR A 111
 None
 1.38A 3glqB-5mlhA:
6.3		 3glqB-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5mlh -
(-) 		5 / 12 ILE A  37
GLY A  36
GLY A  39
ALA A  43
ALA A  62
 NAP  A 404 (-4.0A)
NAP  A 404 (-3.1A)
None
None
NAP  A 404 (-3.5A)
 1.12A 3jayA-5mlhA:
undetectable		 3jayA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5mlh -
(-) 		4 / 8 ILE A  37
TRP A 284
GLY A 204
ASN A 278
 NAP  A 404 (-4.0A)
None
NAP  A 404 (-4.5A)
None
 0.81A 4fgjA-5mlhA:
7.1
4fgjB-5mlhA:
6.9		 4fgjA-5mlhA:
undetectable
4fgjB-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 5mlh -
(-) 		4 / 8 ALA A 382
PHE A 207
VAL A 347
PHE A 343
 None
None
XOG  A 402 (-3.6A)
NAP  A 404 ( 4.8A)
 1.01A 4ltwA-5mlhA:
undetectable		 4ltwA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 5mlh -
(-) 		5 / 12 VAL A  58
GLY A  39
ILE A  75
GLY A  33
ILE A  31
 None
None
None
NAP  A 404 (-3.1A)
None
 0.97A 4q5mA-5mlhA:
undetectable		 4q5mA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5mlh -
(-) 		5 / 12 ILE A 350
PHE A 282
GLY A 239
LEU A 221
PHE A 207
 XOG  A 402 (-4.8A)
None
None
None
None
 1.11A 5fsaA-5mlhA:
undetectable		 5fsaA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5mlh -
(-) 		5 / 12 PRO A 238
LEU A 348
GLU A 301
PHE A 237
GLY A 300
 None
 1.14A 5l6eA-5mlhA:
2.2		 5l6eA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 5mlh -
(-) 		5 / 12 ILE A 156
ALA A 242
ILE A 350
CYH A 352
PRO A 353
 None
None
XOG  A 402 (-4.8A)
XOG  A 402 (-3.8A)
None
 1.45A 5mlmA-5mlhA:
62.8		 5mlmA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 5mlh -
(-) 		11 / 12 LYS A 147
PHE A 153
ILE A 156
ASN A 205
MET A 215
ALA A 243
SER A 248
VAL A 347
ILE A 350
CYH A 352
PRO A 353
 XOG  A 402 ( 2.7A)
XOG  A 402 (-3.9A)
None
XOG  A 402 (-2.8A)
XOG  A 402 ( 4.2A)
XOG  A 402 ( 4.2A)
XOG  A 402 ( 4.6A)
XOG  A 402 (-3.6A)
XOG  A 402 (-4.8A)
XOG  A 402 (-3.8A)
None
 0.55A 5mlmA-5mlhA:
62.8		 5mlmA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 5mlh -
(-) 		11 / 12 ARG A 146
LYS A 147
VAL A 150
PHE A 153
ILE A 156
ASN A 205
MET A 215
SER A 248
TRP A 284
VAL A 347
ILE A 350
 None
XOG  A 402 ( 2.7A)
None
XOG  A 402 (-3.9A)
None
XOG  A 402 (-2.8A)
XOG  A 402 ( 4.2A)
XOG  A 402 ( 4.6A)
None
XOG  A 402 (-3.6A)
XOG  A 402 (-4.8A)
 0.58A 6gsdA-5mlhA:
62.5		 6gsdA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 5mlh -
(-) 		11 / 12 ARG A 146
VAL A 150
PHE A 153
ILE A 156
ASN A 205
MET A 215
SER A 248
TRP A 284
VAL A 347
ILE A 350
CYH A 352
 None
None
XOG  A 402 (-3.9A)
None
XOG  A 402 (-2.8A)
XOG  A 402 ( 4.2A)
XOG  A 402 ( 4.6A)
None
XOG  A 402 (-3.6A)
XOG  A 402 (-4.8A)
XOG  A 402 (-3.8A)
 0.57A 6gsdA-5mlhA:
62.5		 6gsdA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5mlh -
(-) 		4 / 6 ASP A  50
GLU A 258
ASP A 254
GLU A  44
 None
 1.27A 6mn5A-5mlhA:
undetectable		 6mn5A-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5mlh -
(-) 		4 / 6 ASP A  50
GLU A 258
ASP A 254
GLU A  44
 None
 1.34A 6mn5D-5mlhA:
undetectable		 6mn5D-5mlhA:
undetectable