SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mlk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 5mlk ACETYL-COA
CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 225
GLY A 114
ILE A 325
ASP A 107
ILE A 106
 None
 1.01A 1x1aA-5mlkA:
undetectable		 1x1aA-5mlkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 5mlk ACETYL-COA
CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 318
GLN A 222
VAL A 305
ARG A 237
PHE A 323
 None
 1.40A 2yloA-5mlkA:
undetectable		 2yloA-5mlkA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 5mlk ACETYL-COA
CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 425
PRO A 361
GLY A 362
VAL A 427
PRO A 429
 None
 1.11A 3m6vA-5mlkA:
undetectable		 3m6vA-5mlkA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 5mlk ACETYL-COA
CARBOXYLASE
(Mycobacterium
tuberculosis) 		3 / 3 ASN A  86
ALA A  85
LYS A  14
 None
 0.93A 3runA-5mlkA:
undetectable		 3runA-5mlkA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5mlk ACETYL-COA
CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 306
ARG A 347
GLU A 220
GLU A 285
 None
 1.47A 4kr3A-5mlkA:
2.5		 4kr3A-5mlkA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_G_MTXG301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5mlk ACETYL-COA
CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 9 PHE A 296
GLY A 289
LEU A 213
HIS A 450
GLN A 242
 None
 1.41A 4l8wG-5mlkA:
2.3		 4l8wG-5mlkA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1322_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5mlk ACETYL-COA
CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 4 GLU A 285
THR A 283
GLU A 306
LYS A 247
 None
 1.44A 4mghA-5mlkA:
0.0		 4mghA-5mlkA:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 5mlk ACETYL-COA
CARBOXYLASE
(Mycobacterium
tuberculosis) 		7 / 7 LYS A 247
ASN A 300
ARG A 302
GLN A 304
VAL A 305
GLU A 306
ARG A 347
 None
 0.72A 4mv7A-5mlkA:
56.0		 4mv7A-5mlkA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5mlk ACETYL-COA
CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 218
VAL A 219
GLU A 220
LYS A 247
 None
 1.24A 4p6vB-5mlkA:
undetectable
4p6vE-5mlkA:
undetectable		 4p6vB-5mlkA:
20.32
4p6vE-5mlkA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5mlk ACETYL-COA
CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 317
PHE A 323
PRO A 115
ILE A 120
VAL A  25
 None
 1.32A 5dlvB-5mlkA:
undetectable		 5dlvB-5mlkA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5mlk ACETYL-COA
CARBOXYLASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  46
SER A  69
TYR A  70
 None
 0.83A 5glmA-5mlkA:
undetectable		 5glmA-5mlkA:
22.42