SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mlq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5mlq CDPS
(Nocardia
brasiliensis) 		5 / 12 ALA A 115
LEU A  68
ARG A  70
MET A 202
LEU A  32
 None
 1.39A 2oaxC-5mlqA:
undetectable		 2oaxC-5mlqA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 5mlq CDPS
(Nocardia
brasiliensis) 		5 / 12 LEU A 116
ALA A 115
LEU A  68
ARG A  70
LEU A  32
 None
 1.32A 2oaxD-5mlqA:
undetectable		 2oaxD-5mlqA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 5mlq CDPS
(Nocardia
brasiliensis) 		5 / 12 LEU A 116
ALA A 115
LEU A  68
ARG A  70
LEU A  32
 None
 1.38A 2oaxE-5mlqA:
undetectable		 2oaxE-5mlqA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 5mlq CDPS
(Nocardia
brasiliensis) 		5 / 12 LEU A 116
ALA A 115
LEU A  68
ARG A  70
LEU A  32
 None
 1.40A 2oaxF-5mlqA:
undetectable		 2oaxF-5mlqA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5mlq CDPS
(Nocardia
brasiliensis) 		3 / 3 SER A  61
HIS A 186
ASP A 123
 None
CIT  A 301 (-3.8A)
None
 0.53A 2oxtA-5mlqA:
undetectable		 2oxtA-5mlqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5mlq CDPS
(Nocardia
brasiliensis) 		4 / 5 SER A  55
TYR A  15
PHE A  57
VAL A  60
 None
 1.45A 2x7hA-5mlqA:
2.0		 2x7hA-5mlqA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5mlq CDPS
(Nocardia
brasiliensis) 		4 / 5 SER A  55
TYR A  15
PHE A  57
VAL A  60
 None
 1.44A 2x7hB-5mlqA:
undetectable		 2x7hB-5mlqA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5mlq CDPS
(Nocardia
brasiliensis) 		3 / 3 TYR A 194
GLU A 176
THR A 145
 None
 0.85A 2y7hB-5mlqA:
undetectable		 2y7hB-5mlqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_2
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5mlq CDPS
(Nocardia
brasiliensis) 		4 / 6 ASN A  96
TRP A  92
TYR A 194
TRP A 220
 None
 1.35A 3jzjA-5mlqA:
undetectable		 3jzjA-5mlqA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5mlq CDPS
(Nocardia
brasiliensis) 		4 / 5 LEU A 208
ARG A 204
PRO A 137
ALA A 141
 None
 1.27A 3vm4A-5mlqA:
undetectable		 3vm4A-5mlqA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 5mlq CDPS
(Nocardia
brasiliensis) 		5 / 12 ASN A  96
ASP A 101
ILE A 193
LEU A  45
SER A  55
 None
 1.25A 4pooA-5mlqA:
undetectable		 4pooA-5mlqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 5mlq CDPS
(Nocardia
brasiliensis) 		5 / 12 GLU A 175
TRP A 184
ARG A  70
HIS A  40
LEU A  32
 None
 1.09A 4xi3A-5mlqA:
undetectable		 4xi3A-5mlqA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 5mlq CDPS
(Nocardia
brasiliensis) 		5 / 12 GLU A 175
TRP A 184
ARG A  70
HIS A  40
LEU A  32
 None
 1.14A 4xi3D-5mlqA:
undetectable		 4xi3D-5mlqA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 5mlq CDPS
(Nocardia
brasiliensis) 		4 / 5 VAL A 109
THR A 107
ASP A 101
LEU A 100
 None
 1.31A 5m0iB-5mlqA:
undetectable		 5m0iB-5mlqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5mlq CDPS
(Nocardia
brasiliensis) 		5 / 12 THR A 107
VAL A 109
VAL A  64
ASP A 104
TRP A  92
 None
 1.47A 6iblA-5mlqA:
undetectable		 6iblA-5mlqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5mlq CDPS
(Nocardia
brasiliensis) 		5 / 12 THR A 107
VAL A 109
VAL A  64
ASP A 104
TRP A  92
 None
 1.48A 6iblB-5mlqA:
undetectable		 6iblB-5mlqA:
undetectable