SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mlv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5mlv -
(-) 		5 / 12 LEU G 326
VAL G 180
SER G 230
SER G 234
VAL G 240
 None
 1.31A 1ie9A-5mlvG:
undetectable		 1ie9A-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5mlv -
(-) 		5 / 11 SER G 315
ARG G 304
GLY G 363
THR G 194
GLY G 197
 ANP  G 502 (-4.4A)
None
ANP  G 502 ( 4.7A)
ANP  G 502 ( 4.8A)
ANP  G 502 (-3.2A)
 1.23A 1jr1A-5mlvG:
undetectable		 1jr1A-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5mlv -
(-) 		5 / 10 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
 None
 0.90A 1pcgB-5mlvG:
undetectable		 1pcgB-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 5mlv -
(-) 		5 / 10 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
 None
 1.01A 1qktA-5mlvG:
undetectable		 1qktA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 5mlv -
(-) 		5 / 10 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
 None
 0.99A 2ocfA-5mlvG:
undetectable		 2ocfA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5mlv -
(-) 		5 / 12 LEU G 326
VAL G 180
SER G 230
SER G 234
VAL G 240
 None
 1.26A 3m7rA-5mlvG:
undetectable		 3m7rA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5mlv -
(-) 		6 / 12 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
ILE G 428
 None
 1.06A 3olsB-5mlvG:
undetectable		 3olsB-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5mlv -
(-) 		5 / 12 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
 None
 0.96A 3q95A-5mlvG:
undetectable		 3q95A-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5mlv -
(-) 		5 / 12 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
 None
 0.93A 3q95B-5mlvG:
undetectable		 3q95B-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5mlv -
(-) 		5 / 11 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
 None
 0.92A 3uudA-5mlvG:
undetectable		 3uudA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5mlv -
(-) 		4 / 7 LEU G 326
LYS G 351
TYR G 238
LEU G 181
 None
 1.05A 4b3qA-5mlvG:
undetectable		 4b3qA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5mlv -
(-) 		5 / 12 MET G 202
LEU G 219
LEU G 177
MET G 176
ILE G 428
 None
 1.12A 4j24B-5mlvG:
undetectable		 4j24B-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5mlv -
(-) 		4 / 8 LEU G 445
TYR G 153
VAL G 110
LEU G 438
 None
 1.00A 4l1xA-5mlvG:
undetectable		 4l1xA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5mlv -
(-) 		4 / 8 LEU G 445
TYR G 153
VAL G 429
LEU G 438
 None
 0.99A 4l1xA-5mlvG:
undetectable		 4l1xA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 5mlv -
(-) 		3 / 3 SER G 207
ASP G 205
GLN G 165
 None
 0.87A 4oltA-5mlvG:
undetectable
4oltB-5mlvG:
undetectable		 4oltA-5mlvG:
undetectable
4oltB-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 5mlv -
(-) 		5 / 12 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
 None
 0.96A 4pxmA-5mlvG:
undetectable		 4pxmA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 5mlv -
(-) 		3 / 3 GLN G 165
SER G 207
ASP G 205
 None
 0.94A 4qwpA-5mlvG:
undetectable
4qwpB-5mlvG:
undetectable		 4qwpA-5mlvG:
undetectable
4qwpB-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5mlv -
(-) 		5 / 10 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
 None
 0.93A 5dxbA-5mlvG:
undetectable		 5dxbA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5mlv -
(-) 		4 / 8 MET G 202
LEU G 219
LEU G 177
MET G 176
 None
 0.99A 5dxeA-5mlvG:
undetectable		 5dxeA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 5mlv -
(-) 		5 / 10 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
 None
 0.93A 5dxeB-5mlvG:
undetectable		 5dxeB-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5mlv -
(-) 		5 / 10 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
 None
 0.92A 5hyrA-5mlvG:
undetectable		 5hyrA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5mlv -
(-) 		5 / 12 LEU G 219
ALA G 223
LEU G 177
MET G 176
ILE G 428
 None
 0.95A 5toaA-5mlvG:
undetectable		 5toaA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5mlv -
(-) 		5 / 11 GLY G 197
GLY G 363
GLN G 193
THR G 441
THR G 444
 ANP  G 502 (-3.2A)
ANP  G 502 ( 4.7A)
None
None
None
 1.45A 5x1bG-5mlvG:
undetectable
5x1bN-5mlvG:
0.3
5x1bO-5mlvG:
undetectable		 5x1bG-5mlvG:
undetectable
5x1bN-5mlvG:
undetectable
5x1bO-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5mlv -
(-) 		4 / 8 MET G 202
LEU G 219
LEU G 177
MET G 176
 None
 1.00A 6cbzA-5mlvG:
undetectable		 6cbzA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5mlv -
(-) 		4 / 5 GLN G 141
VAL G 128
PRO G 144
THR G 434
 None
 1.37A 6cduA-5mlvG:
undetectable
6cduB-5mlvG:
undetectable		 6cduA-5mlvG:
undetectable
6cduB-5mlvG:
undetectable